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Human TGFB2 Protein expressed in Tobacco (Nicotiana benthamiana) - ABIN1112028
ten Dijke, Hansen, Iwata, Pieler, Foulkes: Identification of another member of the transforming growth factor type beta gene family. in Proceedings of the National Academy of Sciences of the United States of America 1988
Show all 4 Pubmed References
The results of this study found that Bptf and TGF-beta (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins) mediate nucleosome remodeling to regulate wnt8a (show WNT8A Proteins) expression and hence neural posteriorization.
Functional investigation of a subset of these genes, fgf10a (show FGF10 Proteins), tgfb2, pax9 (show PAX9 Proteins), and smad5 (show SMAD5 Proteins) revealed their necessity in zebrafish palatogenesis.
These data suggest Pez (show PTPN14 Proteins) plays a crucial role in organogenesis by inducing TGFbeta (show TGFB1 Proteins) and epithelial-mesenchymal transition.
results imply that the interaction of matrix AGEs with RAGE (show AGER Proteins) plays a role in the TGFbeta2-mediated EMT (show ITK Proteins) of lens epithelial cells and suggest that the blockade of RAGE (show AGER Proteins) could be a strategy to prevent PCO and other age-associated fibrosis.
Data show that just like TGF-beta1 (show TGFB1 Proteins), TGF-beta2 is expressed in and secreted by both, healthy and diseased hepatocytes and hepatic stellate cell (HSCs).
results support that the regulation of miR (show MLXIP Proteins)-30b by VEGF (show VEGFA Proteins) in HUVEC is important for capillary morphogenesis, as increased miR (show MLXIP Proteins)-30b expression inhibits capillary morphogenesis through enhanced expression of TGFbeta2
Data suggest that TGFB2 (the most abundant growth factor in human milk) binding to Tgfb2r elicits robust/rapid response in small intestinal mucosal cells leading to stimulation of Egr1 (show EGR1 Proteins) transport to nucleus and cell differentiation; more than 15 Wnt (show WNT2 Proteins) signaling pathway genes have Egr1 (show EGR1 Proteins) binding sites/response elements; Egr1 (show EGR1 Proteins) binds to Axin1 (show AXIN1 Proteins) promoter and functionally activates gene expression. (Axin1 (show AXIN1 Proteins) = axis inhibition protein 1 (show AXIN1 Proteins))
Hypoxia enhances canonical TGFbeta (show TGFB1 Proteins) signalling, and appears to be a key determinant of Snail's differential involvement in endothelial cell responses to TGFbeta1 (show TGFB1 Proteins) versus TGFbeta2.
RUNX1T1 (show RUNX1T1 Proteins) serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells
TGF-beta2 is a new regulatory factor for KCC2 (show SLC12A5 Proteins) functional activation and membrane trafficking.
There was striking upregulation of TGFB1 (show TGFB1 Proteins) and TGFB2 expression on immunofluorescent staining, and western blotting of the aortic tissue from the index case confirming the functional importance of the variant. This case highlights the striking paradox of predicted loss-of-function mutations in TGFB2 causing enhanced TGFb (show TGFB1 Proteins) signaling in this emerging familial aortopathy.
Our data expand the phenotype of Loeys-Dietz syndrome type 4 : we confirm that TGFb2 mutations are responsible for true Loeys-Dietz (LDS) syndrome with non-specific features of connective tissue disorders and diffuse vascular lesions
TGF-beta (show TGFB1 Proteins) signaling regulated cell growth of cancer associated fibroblasts.
TGF-beta2 as the crucial mediator of neural precursor cell immunomodulation.
CREBH (show CREB3L3 Proteins) was identified as a key positive regulator of TGF-beta2 transcription in hepatitis C virus-infected cells.
The disruption of decorin (show DCN Proteins)-restricted TGFbeta (show TGFB1 Proteins) signalling leads to higher stiffness of articular cartilage matrix, rendering joints more resistant to osteoarthritis.
These data provide new insights in the molecular interaction between Fibulin-4 (show FBLN4 Proteins) and TGF-beta (show TGFB1 Proteins) pathway regulation in the pathogenesis of aortic aneurysms.
APC (show APC Proteins)-derived TSP-1 (show GZMA Proteins) is essential for the development of an adaptive regulatory immune response induced by TGF-beta2-expressing APCs (show APCS Proteins) similar to those located at mucosal and ocular sites.
Epidermal Tgfb2 controls proliferation, differentiation and ECM (show MMRN1 Proteins) production by reticular fibroblasts.
Pathological TGF-beta (show TGFB1 Proteins) release from osteolytic bone metastases contributes to muscle weakness in cancer by decreasing Ca(2 (show CA2 Proteins)+)-induced muscle force production.
Thus, along with TGF-b and MAPK signaling, NFkappaB serves as an important regulatory pathway which following Losartan treatment
Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
Suggest that the interplay between TGFbeta (show TGFB1 Proteins)-2 and LPS (show IRF6 Proteins) regulates the levels of IL-8 (show IL8 Proteins) in the immature newborn intestine.
TGFbeta (show TGFB1 Proteins) may play a role in the overall process of luteinization, but it appears not to influence steroidogenesis in luteinizing pig follicles.
There was no significant change in the expression of TGF-beta(2) and alpha-SMA (show SMN1 Proteins) after laser-assisted intrastromal scanning.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1\;7)(q41\;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
transforming growth factor beta-2
, tgf beta 2
, transforming growth factor, beta 2
, transforming growth factor beta-2-like
, BSC-1 cell growth inhibitor
, glioblastoma-derived T-cell suppressor factor
, TGF beta 2 protein
, milk growth factor
, transforming growth factor beta 2
, Transforming growth factor beta-2
, transforming growth factor-beta 2
, transforming growth factor-beta2
, TGF-beta 2
, TGF-beta receptor type II
, TGF-beta receptor type-2
, TGF-beta type II receptor
, transforming growth factor beta receptor type II
, transforming growth factor beta, receptor 2
, transforming growth factor, beta receptor 2
, transforming growth factor, beta receptor IIT
, transforming growth factor-b type II receptor
, transforming growth factor-beta receptor type II
, transforming growth factor-beta type II receptor