Browse our CDK6 Proteins (CDK6)

Full name:
Cyclin-Dependent Kinase 6 Proteins (CDK6)
On www.antibodies-online.com are 13 Cyclin-Dependent Kinase 6 (CDK6) Proteins from 5 different suppliers available. Additionally we are shipping CDK6 Antibodies (256) and CDK6 Kits (13) and many more products for this protein. A total of 297 CDK6 products are currently listed.
Synonyms:
5830411I20, AI504062, CDK6, Crk2, PLSTIRE
list all proteins Gene Name GeneID UniProt
CDK6 1021 Q00534
CDK6 12571 Q64261
Rat CDK6 CDK6 114483  

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CDK6 Proteins (CDK6) by Origin

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More Proteins for CDK6 Interaction Partners

Human Cyclin-Dependent Kinase 6 (CDK6) interaction partners

  1. Describe a regulatory loop miR (show MLXIP Proteins)-218-CDK6/CyclinD1-E2F1 (show E2F1 Proteins) whose disruption may contribute to cell cycle progression in gastric cancer.

  2. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (show E2F1 Proteins) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 Proteins) inhibitors in breast cancer for the development of more effective combination therapies.

  3. The deletion of CBX3 (show CBX3 Proteins) directly enforces the expression of CDK6 and p21 (show CDKN1A Proteins).

  4. Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.

  5. CDK6-mediated suppression of CD25 (show IL2RA Proteins) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Proteins)

  6. CDK6 overexpression is associated with cancer.

  7. High CDK6 expression is associated with Melanoma.

  8. Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein

  9. Our study proved that the CDK6 gene is a target of miR (show MLXIP Proteins)-637, and demonstrated the regulatory association between miR (show MLXIP Proteins)-637 and CDK6

  10. we verified that miR (show MLXIP Proteins)-892b regulates the p19ARF/cyclin D1 (show CCND1 Proteins)/CDK6 and Sp-1 (show PSG1 Proteins)/MMP-9 (show MMP9 Proteins) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.

Mouse (Murine) Cyclin-Dependent Kinase 6 (CDK6) interaction partners

  1. PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6 (show CDK4 Proteins)), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 (show CDK4 Proteins) inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. CDK6-mediated suppression of CD25 (show IL2RA Proteins) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Proteins). . Pharmacologic inhibition of CDK6 kinase induces CD25 (show IL2RA Proteins) and RUNX1 (show RUNX1 Proteins) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.

  3. Fbxo7 (show FBXO7 Proteins)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (show CDKN1B Proteins) levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Proteins) at different stages in T-cell development.

  4. Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.

  5. Data show that E11/glycoprotein 38 (show PDPN Proteins)(GP38 (show PDPN Proteins)) was up-regulated upon SEMA3A (show SEMA3A Proteins) stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.

  6. Notch3 (show NOTCH3 Proteins) transcription and growth of lymphoma cells was dependent on CDK6.

  7. CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (show EGR1 Proteins) in hematopoietic and leukemic stem cell activation

  8. Cdk4 (show CDK4 Proteins) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4 (show CDK4 Proteins).

  9. Cdk6/Ccnd1 (show CCND1 Proteins) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (show PGR Proteins); the chondrocytes then undergo p53 (show TP53 Proteins)-dependent apoptosis

  10. p107 (show RBL1 Proteins) retinoblastoma protein is regulated by Cdk6/Ccnd1 (show CCND1 Proteins) in growth plates.

Cow (Bovine) Cyclin-Dependent Kinase 6 (CDK6) interaction partners

  1. the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth

CDK6 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with CDK6

  • cyclin-dependent kinase 6 (CDK6)
  • cyclin-dependent kinase 6 (Cdk6)
  • 5830411I20 protein
  • AI504062 protein
  • CDK6 protein
  • Crk2 protein
  • PLSTIRE protein

Protein level used designations for CDK6

cyclin-dependent kinase 6 , cell division protein kinase 6-like , cell division protein kinase 6 , serine/threonine-protein kinase PLSTIRE , CR2 protein kinase

GENE ID SPECIES
746968 Pan troglodytes
100454924 Pongo abelii
1021 Homo sapiens
12571 Mus musculus
114483 Rattus norvegicus
609920 Canis lupus familiaris
511754 Bos taurus
420558 Gallus gallus
100518921 Sus scrofa
100009040 Oryctolagus cuniculus
100061625 Equus caballus
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