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Combined PI3Kalpha (show PIK3CA Proteins) and CDK4/6 (show CDK4 Proteins) inhibition significantly improved disease control in human xenograft models compared with either monotherapy.
in ovarian cancer cells, DOT1L (show DOT1L Proteins) regulates the transcription of G1 phase genes CDK6 and CCND3 (show CCND3 Proteins) through H3K79 dimethylation
the MYU/hnRNP-K (show HNRNPK Proteins)/CDK6 pathway functions downstream of Wnt/c (show WNT7B Proteins)-Myc (show MYC Proteins) signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells.
metabolic function of cyclin D3 (show CCND3 Proteins)-CDK6 kinase in cancer cell survival
Describe a regulatory loop miR (show MLXIP Proteins)-218-CDK6/CyclinD1-E2F1 (show E2F1 Proteins) whose disruption may contribute to cell cycle progression in gastric cancer.
Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (show E2F1 Proteins) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (show CDK4 Proteins) inhibitors in breast cancer for the development of more effective combination therapies.
The deletion of CBX3 (show CBX3 Proteins) directly enforces the expression of CDK6 and p21 (show CDKN1A Proteins).
Amplification of the G1-S regulatory genes, CCNE1, CCND1 and CdK6, represent an early event, which precedes ERBB2, EGFR, or KRAS amplification in gastric adenocarcinoma.
CDK6-mediated suppression of CD25 (show IL2RA Proteins) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Proteins)
CDK6 overexpression is associated with cancer.
PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6 (show CDK4 Proteins)), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 (show CDK4 Proteins) inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.
CDK6-mediated suppression of CD25 (show IL2RA Proteins) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Proteins). . Pharmacologic inhibition of CDK6 kinase induces CD25 (show IL2RA Proteins) and RUNX1 (show RUNX1 Proteins) expression, cell cycle arrest and apoptosis in mouse and human T-ALL.
Fbxo7 (show FBXO7 Proteins)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 (show CDKN1B Proteins) levels. These studies reveal differential cell cycle regulation by Fbxo7 (show FBXO7 Proteins) at different stages in T-cell development.
Taken together, our results suggested that microRNA-33 enhanced the replicative senescence of MEFs potentially by suppressing CDK6 expression.
Data show that E11/glycoprotein 38 (show PDPN Proteins)(GP38 (show PDPN Proteins)) was up-regulated upon SEMA3A (show SEMA3A Proteins) stimulation, and cyclin-dependent kinase 6 (CDK6) was down-regulated in a time-dependent manner.
Notch3 (show NOTCH3 Proteins) transcription and growth of lymphoma cells was dependent on CDK6.
CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (show EGR1 Proteins) in hematopoietic and leukemic stem cell activation
Cdk4 (show CDK4 Proteins) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4 (show CDK4 Proteins).
Cdk6/Ccnd1 (show CCND1 Proteins) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (show PGR Proteins); the chondrocytes then undergo p53 (show TP53 Proteins)-dependent apoptosis
p107 (show RBL1 Proteins) retinoblastoma protein is regulated by Cdk6/Ccnd1 (show CCND1 Proteins) in growth plates.
the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
cyclin-dependent kinase 6
, cell division protein kinase 6-like
, cell division protein kinase 6
, serine/threonine-protein kinase PLSTIRE
, CR2 protein kinase