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we verified that miR (show MLXIP Proteins)-892b regulates the p19ARF/cyclin D1 (show CCND1 Proteins)/CDK6 and Sp-1 (show PSG1 Proteins)/MMP-9 (show MMP9 Proteins) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.
miR (show MLXIP Proteins)-1299 inhibited CDK6 expression and bound to the 3'UTR of CDK6.
Expression of miR (show MLXIP Proteins)-26a and miR (show MLXIP Proteins)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 Proteins), ATP1B1 (show ATP1B1 Proteins), COL4A2 (show COL4a2 Proteins), CPEB3 (show CPEB3 Proteins), CDK6, DNMT3a (show DNMT3A Proteins) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
Data indicate that microRNA miR (show MLXIP Proteins)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A Proteins)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 Proteins)), cyclin (show PCNA Proteins)-dependent kinases CDK3 (show CDK3 Proteins) and CDK6.
The concept that cotargeting MEK and CDK4/6 would prove efficacious in KRAS-mutant (KRAS(mt)) colorectal cancers.
Results show that NEAT1 regulated CDK6 expression in laryngeal squamous cell cancer (LSCC) cells which was mediated by miR (show MLXIP Proteins)-107; NEAT1 plays an oncogenic role in the tumorigenesis of LSCC.
This review highlights our current understanding of CDK (show CDK4 Proteins) signaling in both normal and malignant breast tissues, with special attention placed on recent clinical advances in inhibition of CDK4/6 (show CDK4 Proteins) in ER+ disease
PHD1 (show EGLN2 Proteins) is phosphorylated by CDK2 (show CDK2 Proteins), CDK4 (show CDK4 Proteins) and CDK6 at Serine 130.
A ZFP36L1 (show ZFP36L1 Proteins)-mediated regulatory circuit through repressing CDK6 expression.
concurrent inhibition of ESR1 (show ESR1 Proteins) and the cyclin (show PCNA Proteins)-dependent kinases 4 and 6 (CDK4/6 (show CDK4 Proteins)) significantly increased progression-free survival in advanced patients
Notch3 (show NOTCH3 Proteins) transcription and growth of lymphoma cells was dependent on CDK6.
CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (show EGR1 Proteins) in hematopoietic and leukemic stem cell activation
Cdk4 (show CDK4 Proteins) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4 (show CDK4 Proteins).
Cdk6/Ccnd1 (show CCND1 Proteins) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (show PGR Proteins); the chondrocytes then undergo p53 (show TP53 Proteins)-dependent apoptosis
p107 (show RBL1 Proteins) retinoblastoma protein is regulated by Cdk6/Ccnd1 (show CCND1 Proteins) in growth plates.
A chrysin derivative suppresses skin cancer growth by inhibiting cyclin (show PCNA Proteins)-dependent kinases.
Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons
a mechanism for LPS (show TLR4 Proteins) signaling which involves a decrease in miR (show MLXIP Proteins)-107 leading to an increase in CDK6
an important role for CDK6 kinase activity in thymocyte development that operates partially through modulating Notch (show NOTCH1 Proteins) target gene expression.
we identify CDK6 as relevant and critical target of AP-1 (show JUN Proteins)-regulated DNA methylation (show HELLS Proteins) on BCR-ABL (show ABL1 Proteins)-induced transformation, thereby accelerating leukemogenesis
the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
cyclin-dependent kinase 6
, cell division protein kinase 6-like
, cell division protein kinase 6
, serine/threonine-protein kinase PLSTIRE
, CR2 protein kinase