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Browse our anti-CDK9 (CDK9) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 9 Antibodies (CDK9)
On www.antibodies-online.com are 132 Cyclin-Dependent Kinase 9 (CDK9) Antibodies from 22 different suppliers available. Additionally we are shipping CDK9 Kits (28) and CDK9 Proteins (9) and many more products for this protein. A total of 175 CDK9 products are currently listed.
Synonyms:
C-2k, CDC2L4, cdk9, CG5179, CTK1, Dmel\\CG5179, P-TEF, P-TEFb, PITALRE, PTefb, TAK, wu:fb22e09, wu:fc06c02

All available anti-CDK9 Antibodies

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Top referenced anti-CDK9 Antibodies

  1. Human Polyclonal CDK9 Primary Antibody for EIA, IHC (fro) - ABIN116944 : Castaneda, Garcia, Gra, Nodarse-Cuni, Garcia, Andrade, Martinez, Trujillo, Soto, Amoroto, Viada, Lopez-Saura: [Interferon alfa 2b treatment decreases histological activity in children with chronic hepatitis B] in Acta gastroenterologica Latinoamericana 2002 (PubMed)
    Show all 7 references for ABIN116944

  2. Human Polyclonal CDK9 Primary Antibody for EIA, IP - ABIN401390 : Jang, Mochizuki, Zhou, Jeong, Brady, Ozato: The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. in Molecular cell 2005 (PubMed)
    Show all 5 references for ABIN401390

  3. Human Monoclonal CDK9 Primary Antibody for IHC, ELISA - ABIN969042 : Montanuy, Torremocha, Hernández-Munain, Suñé: Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969042

  4. Human Polyclonal CDK9 Primary Antibody for IHC, WB - ABIN2792147 : Sabò, Lusic, Cereseto, Giacca: Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. in Molecular and cellular biology 2008 (PubMed)

  5. Human Polyclonal CDK9 Primary Antibody for ELISA, WB - ABIN1531647 : Liu, Rice: Genomic organization and characterization of promoter function of the human CDK9 gene. in Gene 2000 (PubMed)

  6. Human Polyclonal CDK9 Primary Antibody for EIA, IHC (fro) - ABIN121519 : Graña, De Luca, Sang, Fu, Claudio, Rosenblatt, Morgan, Giordano: PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)

  7. Chicken Polyclonal CDK9 Primary Antibody for WB - ABIN2792148 : Li, Price, Byers, Cheng, Peng, Price: Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. in The Journal of biological chemistry 2005 (PubMed)

More Antibodies against CDK9 Interaction Partners

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. actin (show ACTB Antibodies) participates in transcription elongation by recruiting Cdk9,a catalytic subunit of P-TEFb, for phosphorylation of the Pol II C-terminal domain, and the actin (show ACTB Antibodies)-Cdk9 interaction promotes chromatin remodeling

  2. Genetic transcription and RNA processing of PTefb kinase is coordinated on heat shock genes.

  3. Cdk9 is required for heat shock gene expression, histone methylation and elongation factor (show TSFM Antibodies) recruitment.

Human Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. Systematic Determination of Human CDK9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DDX5 (show DDX5 Antibodies) and DDX17 (show DDX17 Antibodies) RNA Helicases

  2. In vitro phosphorylation of pUL69 by CDK9 or pUL97 did not occur in a single site-specific manner, but at multiple sites.

  3. the introduction of HIV-1 Tat (show TAT Antibodies) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9/cyclin T1 (show CCNT1 Antibodies) complex

  4. miR (show MLXIP Antibodies)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9, NOTCH2 (show NOTCH2 Antibodies), and RPS6KA3 (show RPS6KA3 Antibodies).

  5. Essential for MYC (show MYC Antibodies) expreession increase upon CDK9 inhibition is that the bromodomain protein BRD4 (show BRD4 Antibodies) captures P-TEFb (show CCNT1 Antibodies) from 7SK snRNP (show LSM2 Antibodies) to deliver to target genes and also enhances CDK9's activity and resistance to inhibition.

  6. Suggest up-regulation of CDK9 kinase activity and Mcl-1 (show MCL1 Antibodies) stability contributes to the acquired resistance to cyclin-dependent kinase (show CDK1 Antibodies) inhibitors in leukemia.

  7. Transcription is effective if RELA (show NFkBP65 Antibodies) recruits the positive transcription elongation factor b (P-TEFb) component CDK9 to a combined RELA (show NFkBP65 Antibodies)/STAT3 (show STAT3 Antibodies) binding site -50 to -20bp upstream of the start site of the IL-12p35 promoter

  8. Thus, inhibition of CDK9 may represent an interesting approach as a cancer therapeutic target, especially in hematologic malignancies.

  9. MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9

  10. Plk1 (show PLK1 Antibodies) negatively regulates the RNA polymerase II-dependent transcription through inhibiting the activity of cyclin T1 (show CCNT1 Antibodies)/Cdk9 complex.

Pig (Porcine) Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. inhibition of CDK9 abrogated global transcriptional activity and rRNA production. Collectively, our data suggested that P-TEFb (show CCNT1 Antibodies) kinase activity is crucial for oocyte maturation, embryo development and regulation of RNA transcription in pig.

Mouse (Murine) Cyclin-Dependent Kinase 9 (CDK9) interaction partners

  1. identified cyclin-dependent kinase 9 (Cdk9) as required for hepatocellular carcinoma disease maintenance

  2. This study demonstrates that Ikaros (show IKZF1 Antibodies) directly interacts with GATA1 (show GATA1 Antibodies), GATA2 (show GATA2 Antibodies), and GATA3 (show GATA3 Antibodies) as well as Cdk9/P-TEFb through specific protein domains.

  3. Data show that the minimal 90-amino acid AF9 (show MLLT3 Antibodies) fragment in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) retains an ability to form higher order complexes with AF4*P-TEFb (show CCNT1 Antibodies) and with DOT1 (show DOT1L Antibodies).

  4. Data show that the CDK9 and cyclin T1 (show CCNT1 Antibodies) subunits of P-TEFb (show CCNT1 Antibodies) are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.

  5. The present study examined whether Cdk9 forms a complex with GATA4 (show GATA4 Antibodies) in mouse embryonic stem cells and is involved in their differentiation into cardiomyocytes.

  6. Data report that a second cdk9 isoform, termed cdk9-55, plays a fundamental role in muscle regeneration and differentiation in vivo.

  7. role in activating MyoD (show MYOD1 Antibodies)-dependent transcription

  8. CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 (show CCNT1 Antibodies) promotes its nuclear localization.

  9. chronic activation of Cdk9 causes not only cardiomyocyte enlargement but also defective mitochondrial function, via diminished PGC-1 (show PPARGC1A Antibodies) transcription, and a resulting susceptibility to apoptotic cardiomyopathy

  10. PPARgamma (show PPARG Antibodies)-cdk9 interaction results in increased transcriptional activity of PPARgamma (show PPARG Antibodies) and therefore increased adipogenesis.

CDK9 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

Alternative names and synonyms associated with CDK9

  • Cyclin-dependent kinase 9 (Cdk9) antibody
  • cyclin-dependent kinase 9 (CDK9) antibody
  • cyclin-dependent kinase 9 (cdk9) antibody
  • cyclin-dependent kinase 9 (Cdk9) antibody
  • cyclin-dependent kinase 9 (cdk9-a) antibody
  • cyclin-dependent kinase 9 (CDC2-related kinase) (Cdk9) antibody
  • cyclin-dependent kinase 9 (CDC2-related kinase) (cdk9) antibody
  • cyclin-dependent kinase 9-like (LOC100855805) antibody
  • C-2k antibody
  • CDC2L4 antibody
  • cdk9 antibody
  • CG5179 antibody
  • CTK1 antibody
  • Dmel\\CG5179 antibody
  • P-TEF antibody
  • P-TEFb antibody
  • PITALRE antibody
  • PTefb antibody
  • TAK antibody
  • wu:fb22e09 antibody
  • wu:fc06c02 antibody

Protein level used designations for CDK9

CG5179-PA , Cdk9-PA , Cyclin-dependent kinase9 2.7 , p43 PITALRE , positive transcription elongation factor b , positive transcription elongation factor b, small subunit , cyclin-dependent kinase 9 (CDC2-related kinase) , cell division protein kinase 9 , CDC2-related kinase , cell division cycle 2-like protein kinase 4 , serine/threonine protein kinase PITALRE , serine/threonine-protein kinase PITALRE , tat-associated kinase complex catalytic subunit , cell division protein kinase 9-A , cyclin-dependent kinase 9-A , cyclin-dependent kinase 9

GENE ID SPECIES
37586 Drosophila melanogaster
464755 Pan troglodytes
448039 Xenopus (Silurana) tropicalis
1025 Homo sapiens
362110 Rattus norvegicus
735101 Xenopus laevis
417226 Gallus gallus
100307051 Sus scrofa
520580 Bos taurus
100725846 Cavia porcellus
101109788 Ovis aries
107951 Mus musculus
321602 Danio rerio
100855805 Canis lupus familiaris
491325 Canis lupus familiaris
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