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anti-Human CDKN1A Antibodies:
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These findings demonstrated that p21 plays a critical role in furazolidone-induced apoptosis in HepG2 cells by influencing the caspase-3 (show CASP3 Antibodies) activation and ROS (show ROS1 Antibodies) generation.
results suggested that high CDKN1A/p21 and low TGFBR2 (show TGFBR2 Antibodies) expression was closely correlated with adverse pathological parameters and poor prognosis in breast cancer.
Study provides evidence that miR (show MLXIP Antibodies)-208a can affect the proliferation and radio-sensitivity of human lung cancer cells by targeting p21.
Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 (show CCNG2 Antibodies) in human brain microvascular endothelial cells.
Estrogen-related receptor gamma (show ESRRG Antibodies) is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27 (show PAK2 Antibodies).
accumulation of HDAC4 (show HDAC4 Antibodies) induced by fibrillar collagen matrices in the nucleus via co-localization of PP1alpha (show PPP1CA Antibodies), leads to repression of the mRNA/protein of p21 and in turn promotes the proliferation and migration of epithelial ovarian cancer cells
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21, p27 (show PAK2 Antibodies)-cyclin E (show CCNE1 Antibodies),A/Cdk2 (show CDK2 Antibodies) pathway.
Suggest that the p53 (show TP53 Antibodies)-p21-DREAM-CDE/CHR pathway regulates p53 (show TP53 Antibodies)-dependent repression of Survivin (show BIRC5 Antibodies), CDC25C (show CDC25C Antibodies), and PLK1 (show PLK1 Antibodies) in HCT116 cells.
Overexpression of miR (show MLXIP Antibodies)-512-5p led to the decrease of p21 protein (show NRAS Antibodies).
Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Antibodies) formation upstream of AMP-activated protein kinase (show PRKAA2 Antibodies) and protein kinase (show CDK7 Antibodies) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Antibodies) pathways and p21 Cip1 expression.
The lack of functional Waf1 is indispensable for maintaining self-renewal and pluripotency of embryonic stem cells.
p27(Kip1 (show CDKN1B Antibodies)) and p21(Cip1) are insufficient for the proliferative inhibition of smooth muscle cells cultured in type 1 collagen.
Foxo3 (show FOXO3 Antibodies) circular RNA retards cell cycle progression via forming ternary complexes with p21 (show D4S234E Antibodies) and CDK2 (show CDK2 Antibodies).
TFAP2C (show TFAP2C Antibodies) in trophoblasts controls proliferation by repressing Cdkn1a and activating the MAPK (show MAPK1 Antibodies) pathway, further supporting differentiation of glycogen (show GYS1 Antibodies) cells by activating the AKT (show AKT1 Antibodies) pathway
Interaction between ASPM (show ASPM Antibodies) and the Cdk2 (show CDK2 Antibodies)/Cyclin E (show CCNE1 Antibodies) complex regulated the Cyclin (show PCNA Antibodies) activity by modulating its ubiquitination and localization into the nucleus.
we present evidence that VPA administration to mice increases hippocampal p21 (show D4S234E Antibodies) expression, accompanied by DNA demethylation at the distal CpG island.
LKB1 (show STK11 Antibodies) mediates CDKN1A degradation in response to ultraviolet DNA damage.
At high glucose concentrations in vitro, AdipoR1 (show ADIPOR1 Antibodies) regulated the survival of neural stem cells through the p53 (show TP53 Antibodies)/p21 (show D4S234E Antibodies) pathway and the proliferation- and differentiation-related factors of neural stem cells via TLX (show NR2E1 Antibodies).
Phosphorylation of p53 (show TP53 Antibodies) by LRRK2 (show LRRK2 Antibodies) induces p21(WAF1/CIP1) expression and apoptosis.
AMP-18 (show GKN1 Antibodies) appears to act through PI3K/AKT (show AKT1 Antibodies) pathways to increase p21 (show D4S234E Antibodies) phosphorylation, thereby reducing its nuclear accumulation to overcome the antiproliferative effects of TNF-alpha (show TNF Antibodies).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, cyclin-dependent kinase inhibitor 1
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein