Browse our anti-COPS8 (COPS8) Antibodies

On are 68 COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) Antibodies from 20 different suppliers available. Additionally we are shipping COPS8 Proteins (12) and many more products for this protein. A total of 89 COPS8 products are currently listed.
9430009J09Rik, AA408242, CG13383, CG33297, CG42522, CH8, CONSTITUTIVE PHOTOMORPHOGENIC 9, COP9, COP9 SIGNALOSOME SUBUNIT 8, cops8, CSN8, Dch8, DDBDRAFT_0167123, DDBDRAFT_0233107, DDB_0167123, DDB_0233107, DL3095C, Dmel\\CG42522, Dmel_CG13383, EMB143, EMBRYO DEFECTIVE 143, FCAALL.131, FUS7, FUSCA 7, FUSCA PROTEIN FUS7, l(2)SH2 1829, l(2)SH1829, MGC76051, MGC80215, MGC86182, SGN8, zgc:56319, zgc:86840
list all antibodies Gene Name GeneID UniProt
COPS8 108679 Q8VBV7
COPS8 10920 Q99627
COPS8 363283 Q6P4Z9

Most Popular Reactivities for anti-COPS8 (COPS8) Antibodies

anti-Mouse (Murine) COPS8 Antibodies:

anti-Human COPS8 Antibodies:

anti-Rat (Rattus) COPS8 Antibodies:

All available anti-COPS8 Antibodies

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More Antibodies against COPS8 Interaction Partners

Fruit Fly (Drosophila melanogaster) COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. Mutants in protein phosphatase type 2A (PP2A (show PPP2R2B Antibodies)) also display reduced genome-wide H3 dephosphorylation, and sites of H3 phosphorylation that do not contain heat shock genes remain transcriptionally active during heat shock in PP2A (show PPP2R2B Antibodies) mutants.

  2. CSN8 is present exclusively as part of the CSN holo-complex, and lack of CSN8 in the mutants leads to CSN instability. Consistent with this, Cullin (show CUL5 Antibodies) deneddylation is impaired in the csn8(null) mutants.

Mouse (Murine) COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. CSN8/CSN promotes the ubiquitination and degradation of misfolded proteins and protects against cardiac proteotoxicity, and cullin-RING ligases participate in degradation of cytosolic misfolded proteins.

  2. Csn8 exerts profound impacts on hepatic ubiquitin-proteasome system function and is critical to the stability of the pro-apoptotic protein Bim (show BCL2L11 Antibodies).

  3. CSN8/COP9 signalosome regulates both proteasome-mediated proteolysis and the autophagic-lysosomal pathway, critical to the removal of oxidized proteins in the heart.

  4. Data indicate that a decreased level of Csn8 accelerated cell growth and shortened G1 duration. (show COPS5 Antibodies)

  5. Likely through regulating the expression of Rab7 (show RAB7A Antibodies), Csn8/CSN plays a critical role in autophagosome maturation in myocardium.

  6. The Csn8 is essential to the ability of mature hepatocytes to proliferate effectively in response to hepatic injury.

  7. Csn8/CSN plays an essential role in cullin deneddylation, UPS-mediated degradation of a subset of proteins, and the survival of cardiomyocytes

Arabidopsis thaliana COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. while constitutively photomorphogenic9 (COP9) signalosome (CSN) mutants can complete embryogenesis and are able to germinate, they progressively lose meristem activity upon germination until they become unable to sustain growth

  2. This review provides an overview of the highly complex regulation of CULLIN-RING E3 ubiquitin ligase (show MUL1 Antibodies) activity by COP9 signalosome (CSN), and the many roles of the CSN in plant development and defense.

  3. SMAP1 (show SMAP1 Antibodies) interacts with the COP9 signalosome.

  4. study concludes that the COP9 signalosome maintains a precise regulation of eIF3e (show EIF3E Antibodies) levels, which is necessary for normal development in Arabidopsis

  5. COP9 has a role in ethylene signaling.

  6. COP9 signalosome- and 26S proteasome (show Psmd4 Antibodies)-dependent regulation of SCFTIR1 accumulation in Arabidopsis

Human COP9 Constitutive Photomorphogenic Homolog Subunit 8 (Arabidopsis) (COPS8) interaction partners

  1. Data indicate that silencing of Csn8 caused an increased growth rate, whereas silencing of Csn5 (show COPS5 Antibodies) impaired proliferation in HeLa cells.

  2. miR (show MLXIP Antibodies)-146a expression is up-regulated in a majority of gastric cancers where it targets CARD10 (show CARD10 Antibodies) and COPS8, inhibiting GPCR (show NMUR1 Antibodies)-mediated activation of NF-kappaB (show NFKB1 Antibodies).

  3. analysis of the COP9 signalosome and its common architecture with the 26S proteasome (show Psmd4 Antibodies) lid and eIF3 (show EIF3A Antibodies)

  4. DDB2 (show DDB2 Antibodies) and CSA (show ERCC8 Antibodies) are each integrated into nearly identical complexes via interaction with DDB1 (show DDB1 Antibodies). Both complexes contain cullin 4A (show CUL4A Antibodies) and Roc1 (show RIT1 Antibodies) and display ubiquitin ligase activity. They also contain the COP9 signalosome (CSN)

  5. The COP9 signalosome (CSN) controls NF-kappaB (show NFKB1 Antibodies) by deubiquitinylation of IkappaBalpha (show NFKBIA Antibodies).

  6. COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination

COPS8 Antigen Profile

Antigen Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with COPS8

  • COP9 complex homolog subunit 8 (CSN8) antibody
  • COP9 constitutive photomorphogenic homolog subunit 8 (csn8) antibody
  • COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8) antibody
  • MGC80215 protein (MGC80215) antibody
  • COP9 signalosome complex subunit 8 (CSN8) antibody
  • COP9 signalosome complex subunit 8 (csn8) antibody
  • COP9 (constitutive photomorphogenic) homolog, subunit 8 (cops8) antibody
  • COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) (Cops8) antibody
  • COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (cops8) antibody
  • COP9 signalosome complex subunit 8 (COP9) antibody
  • COP9 signalosome subunit 8 (COPS8) antibody
  • COP9 signalosome subunit 8 (Cops8) antibody
  • 9430009J09Rik antibody
  • AA408242 antibody
  • CG13383 antibody
  • CG33297 antibody
  • CG42522 antibody
  • CH8 antibody
  • COP9 antibody
  • cops8 antibody
  • CSN8 antibody
  • Dch8 antibody
  • DDBDRAFT_0167123 antibody
  • DDBDRAFT_0233107 antibody
  • DDB_0167123 antibody
  • DDB_0233107 antibody
  • DL3095C antibody
  • Dmel\\CG42522 antibody
  • Dmel_CG13383 antibody
  • EMB143 antibody
  • EMBRYO DEFECTIVE 143 antibody
  • FCAALL.131 antibody
  • FUS7 antibody
  • FUSCA 7 antibody
  • FUSCA PROTEIN FUS7 antibody
  • l(2)SH2 1829 antibody
  • l(2)SH1829 antibody
  • MGC76051 antibody
  • MGC80215 antibody
  • MGC86182 antibody
  • SGN8 antibody
  • zgc:56319 antibody
  • zgc:86840 antibody

Protein level used designations for COPS8

CG42522-PB , CSN8-PB , Cop9 signalosome subunit 8 , drosophila COP9 signalosome homolog 8 , lethal (2) SH1829 , COP9 signalosome complex subunit 8 , signalosome subunit 8 , COP9 signalosome subunit 8 , MGC80215 protein , COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) , COP9 (constitutive photomorphogenic) homolog, subunit 8 , COP9 homolog , JAB1-containing signalosome subunit 8 , COP9 constitutive photomorphogenic homolog subunit 8 , hCOP9 , SGN8

49077 Drosophila melanogaster
394711 Xenopus (Silurana) tropicalis
424020 Gallus gallus
443917 Xenopus laevis
8620221 Dictyostelium discoideum AX4
100286467 Salmo salar
460043 Pan troglodytes
477417 Canis lupus familiaris
540493 Bos taurus
447626 Xenopus laevis
108679 Mus musculus
100171561 Pongo abelii
393198 Danio rerio
827049 Arabidopsis thaliana
10920 Homo sapiens
363283 Rattus norvegicus
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