COPS8 antibody (Middle Region)

Catalog No. ABIN2784840

Cited in 1 publication. The Rabbit Polyclonal anti-COPS8 antibody (ABIN2784840) specifically detects COPS8 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Cow, Guinea Pig, Horse, Rabbit and Dog samples.

Quick Overview for COPS8 antibody (Middle Region) (ABIN2784840)

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Reactivity: Human, Rat, Mouse, Cow, Guinea Pig, Horse, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-COPS8 Antibody

Binding Specificity: Middle Region

Purpose: COPS8 Antibody - middle region

Sequence: TRMVLPRKPV AGALDVSFNK FIPLSEPAPV PPIPNEQQLA RLTDYVAFLE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against COPS8. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COPS8

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP52242-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-COPS8 antibody (ABIN2784840)

Pick, Golan, Zimbler, Guo, Sharaby, Tsuge, Hofmann, Wei: "The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain." in: PLoS ONE, Vol. 7, Issue 8, pp. e43980, (2012) (PubMed).

Target Details for COPS8

Target: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Alternative Name: COPS8

Background:

Targeted Subunit: 8

Background Information: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene Name: COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

Alternative Symbols: COP9, CSN8, SGN8

Protein Name: COP9 signalosome complex subunit 8

Molecular Weight: 23kDa

Gene ID: 10920

NCBI Accession: NP_006701

UniProt: Q99627

Pathways: Cell Division Cycle