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COPS8 antibody (AA 150-198) (HRP)

COPS8 Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN7148510
  • Target See all COPS8 Antibodies
    COPS8 (COP9 Signalosome Subunit 8 (COPS8))
    Binding Specificity
    • 15
    • 9
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    AA 150-198
    Reactivity
    • 48
    • 23
    • 22
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 43
    • 5
    Rabbit
    Clonality
    • 46
    • 2
    Polyclonal
    Conjugate
    • 21
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This COPS8 antibody is conjugated to HRP
    Application
    • 43
    • 19
    • 13
    • 6
    • 5
    • 5
    • 2
    • 2
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA)
    Isotype
    IgG
    Top Product
    Discover our top product COPS8 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    COPS8 (COP9 Signalosome Subunit 8 (COPS8))
    Alternative Name
    COPS8 (COPS8 Products)
    Synonyms
    COP9 antibody, CSN8 antibody, SGN8 antibody, csn8 antibody, cops8 antibody, MGC76051 antibody, MGC80215 antibody, DDBDRAFT_0167123 antibody, DDBDRAFT_0233107 antibody, DDB_0167123 antibody, DDB_0233107 antibody, zgc:56319 antibody, zgc:86840 antibody, MGC86182 antibody, 9430009J09Rik antibody, AA408242 antibody, Csn8 antibody, Sgn8 antibody, CONSTITUTIVE PHOTOMORPHOGENIC 9 antibody, COP9 SIGNALOSOME SUBUNIT 8 antibody, DL3095C antibody, EMB143 antibody, EMBRYO DEFECTIVE 143 antibody, FCAALL.131 antibody, FUS7 antibody, FUSCA 7 antibody, FUSCA PROTEIN FUS7 antibody, CG13383 antibody, CG33297 antibody, CG42522 antibody, CH8 antibody, Dch8 antibody, Dmel\\CG42522 antibody, Dmel_CG13383 antibody, l(2)SH1829 antibody, l(2)SH2 1829 antibody, COP9 signalosome subunit 8 antibody, COP9 signalosome subunit 8 S homeolog antibody, COP9 signalosome complex subunit 8 antibody, COP9 signalosome subunit 8 L homeolog antibody, COP9 signalosome, subunit CSN8 antibody, COPS8 antibody, Cops8 antibody, cops8 antibody, cops8.S antibody, CSN8 antibody, csn8 antibody, cops8.L antibody, COP9 antibody
    Background

    Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

    Aliases: COP9 homolog antibody, COP9 signalosome complex subunit 8 antibody, COP9 signalosome subunit 8 antibody, Cops8 antibody, CSN8 antibody, CSN8_HUMAN antibody, hCOP9 antibody, JAB1 containing signalosome subunit 8 antibody, JAB1-containing signalosome subunit 8 antibody, SGN8 antibody, Signalosome subunit 8 antibody

    UniProt
    Q99627
    Pathways
    Cell Division Cycle
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