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Human FOXO3 ELISA Kit for Sandwich ELISA - ABIN1000112
Leti, Malenica, Doshi, Courtright, Van Keuren-Jensen, Legendre, Still, Gerhard, DiStefano: High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. in Translational research : the journal of laboratory and clinical medicine 2015
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by modulating hypoxia-inducible factor activity via up-regulation of VHL (show VHL ELISA Kits), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
we demonstrated that REP1 blocked the nuclear trans-localization of FOXO3 through physically interacting with FOXO3, thereby suppressing FOXO3-mediated apoptosis. Importantly, the inhibition of REP1 combined with 5-FU treatment could lead to significant retarded tumor growth in a xenograft tumor model of human cancer cells
TLR4 (show TLR4 ELISA Kits) and C5aR (show C5AR1 ELISA Kits) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 ELISA Kits), PI3Kbeta, SGK1 (show SGK1 ELISA Kits), and FOXO transcription factors.
FoxO3a is an early stress response protein to glucose toxicity in diabetic conditions.
In cigarette smoke extract stimulated bronchial epithelial cells, carbocysteine increased cell proliferation, and SIRT1 (show SIRT1 ELISA Kits) and FoxO3 nuclear expression, and reduced beta galactosidase (show GLB1 ELISA Kits) and survivin (show BIRC5 ELISA Kits) expression.
geminin selectively couples the transcription factor forkhead box O3 (FoxO3) to HDAC3, thereby specifically facilitating FoxO3 deacetylation.
Data suggest that forkhead box O3A protein (FoxO3a) might be a prognostic biomarker or a potential therapeutic target in glioblastoma.
our data demonstrated that FOXO3 is essential for CD44 expression and the properties of cancer stem cells (CSCs). Our data also indicated that patients with high FOXO3 activation signatures had poor prognoses. This evidence suggested that cGMP induction and FOXO3 inhibition could be ideal candidates for pancreatic CSC
adipose stem cell extract regulates Abeta (show APP ELISA Kits)-induced mitochondrial apoptosis via regulation of P53 (show TP53 ELISA Kits)/foxo3a pathway
Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F (show HNRNPF ELISA Kits), SIRTUIN-1 (show SIRT1 ELISA Kits), and FOXO3alpha than nondiabetic kidneys.
acetylation is permissive for generation of the apoptotic form of FOXO3 and the activity of SIRT1 (show SIRT1 ELISA Kits) and particularly SIRT7 (show SIRT7 ELISA Kits) regulate this process in vivo, allowing control of monocyte apoptosis in response to LPS (show IRF6 ELISA Kits).
MiR (show MLXIP ELISA Kits)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
Our results show for the first time that DC FOXO3 expression and function is altered in females. In vitro results indicate that these differences may be the result of exposure to estrogen. These differences may be critical considerations for the enhancement of immunotherapy for cancer.
Data, including data from studies using transgenic/knockout mice, suggest that FoxO3 activation via post-translational phosphorylation can both induce and maintain autophagic activities in renal tubule epithelium in response to injury from unilateral ureteral obstruction; under these conditions, nuclear expression of FoxO3 is up-regulated in hypoxic proximal tubules exhibiting high levels of autophagy.
The Foxo3-Eomes (show EOMES ELISA Kits) pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (show HAND1 ELISA Kits) cell differentiation.
these results show that Cdk5 (show CDK5 ELISA Kits)-mediated phospho-regulation of Foxo3 can activate several genes that promote neuronal death and aberrant Abeta (show APP ELISA Kits) processing, thereby contributing to the progression of neurodegenerative pathologies.
the transcription factor Forkhead box O3 (FoxO3) was found to be an essential regulator of the maintenance of pluripotency in dormant embryonic stem cells.
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 (show IL6 ELISA Kits) in the blood.
results indicate that DNA damage accrued as a result of elevated ROS in Foxo3(-/-) mutant HSPC is at least partially reversible
Foxo1 (show FOXO1 ELISA Kits), Foxo3a, and Foxo4 (show FOXO4 ELISA Kits) in chondrocytes regulate endochondral bone formation.
Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 (show SIRT3 ELISA Kits) enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha (show PPARGC1A ELISA Kits) and SOD2 (show SOD2 ELISA Kits).
These results indicate that myostatin (show MSTN ELISA Kits) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (show NR3C1 ELISA Kits) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (show AKT1 ELISA Kits) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
NO/protein kinase (show CDK7 ELISA Kits) G (PKG (show PRKG1 ELISA Kits))-dependent downregulation of PGC-1 alpha (show PPARGC1A ELISA Kits) and the ROS (show ROS1 ELISA Kits) detoxification system in endothelial cells are mediated by the PI3K/Akt (show AKT1 ELISA Kits) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (show ROS1 ELISA Kits)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3
, forkhead box O3A
, forkhead box O protein
, forkhead box protein O3-like
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor