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Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family
Both the F-box domain of Skp2 and Skp1-Skp2 domain motions displaying preferential conformational control can together facilitate polyubiquitination of a wide variety of substrates.
Skp1 is critical to lung cancer pathogenesis
Data show that epithelial-mesenchymal transition (EMT (show ITK ELISA Kits))-transcription factors can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam (show PAM ELISA Kits)-Fbxo45 (show FBXO45 ELISA Kits) (SPFFbxo45).
We discuss how these results can explain the rapid association of Cdc34 (show CDC34 ELISA Kits) and Skp1-cullin-F-box ligase (SCF (show KITLG ELISA Kits)).
SKP1 variation modifies association between Parkinson's disease and ubiquitin-proteasome system-inhibiting pesticides
Studies indicate that in SCFs, Rbx1 serves as the RING-containing enzyme, Cul1 (show CUL1 ELISA Kits) is the Cullin scaffold, and Skp1 is an adaptor, which serves to link the beta-TrCP (show BTRC ELISA Kits) F-box substrate-specific factor to the rest of the ligase.
Substrate binding promotes formation of the Skp1-Cul1 (show CUL1 ELISA Kits)-Fbxl3 (show FBXL3 ELISA Kits) (SCF (show KITLG ELISA Kits)(Fbxl3 (show FBXL3 ELISA Kits))) protein complex.
Skp1-Cul1 (show CUL1 ELISA Kits)-F-box ubiquitin ligase (SCF (show KITLG ELISA Kits)(betaTrCP (show BTRC ELISA Kits)))-mediated destruction of the ubiquitin-specific protease USP37 (show USP37 ELISA Kits) during G2-phase promotes mitotic entry
Deconjugation of Nedd8 (show NEDD8 ELISA Kits) from Cul1 (show CUL1 ELISA Kits) is directly regulated by Skp1-F-box and substrate, and the COP9 (show COPS8 ELISA Kits) signalosome inhibits deneddylated SCF (show KITLG ELISA Kits) by a noncatalytic mechanism.
The SCF (show KITLG ELISA Kits)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 ELISA Kits).
How ASK1 might regulate protein stability and further downstream gene expression
ABA induced the phosphorylation of three basic helix-loop-helix (bHLH) transcription factors, called AKSs (ABA-responsive kinase substrates; AKS1, AKS2, and AKS3), in Arabidopsis guard cells
ASK1 and ASK2, are required for Agrobacterium-mediated plant transformation.
ASK1 or ASK2 overexpression could rescue or partially rescue the Abscisic acid (ABA)insensitivity of abi5-1 mutants, respectively.
ASK1 is predominately expressed from leptotene to pachytene, and negatively regulates recombination in Arabidopsis.
Through the ASK1-mediated proteolysis pathway, ASK1 proteins showed pleiotropic functions including photomorphogenesis, circadian oscillation, post-translation process, stress-responses and cell expansion or elongation.
ASK1 is required for normal SYN1 distribution during meiotic prophase I and suggest that ask1 associated defects may be primarily related to SYN1 mislocalization.
These results raise the interesting possibility that ASK1 controls chromatin structure by targeting of either an early regulator of meiotic progression or possibly matrix attachment proteins for destruction.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
In this review, deficiency of SKP1A in SN4741 cells closely recapitulates cardinal (show CARD8 ELISA Kits) features of the dopamine (DA) neuron pathology of human Parkinson's disease, such as decreased expression of DA phenotypic markers and cell cycle aberrations.
phosphorylated NIPA (show ZC3HC1 ELISA Kits) is degraded in late mitosis in an APC (show APC ELISA Kits)/C(Cdh1 (show CDH1 ELISA Kits))-dependent manner
Skp1 is a potential modifier in sporadic Parkinson disease neurodegeneration
study evaluated the conformational stabilities of OCP1 (show FBXO2 ELISA Kits) and OCP2
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
S-phase kinase-associated protein 1
, SCF complex component
, S-phase kinase-associated protein 1A
, S-phase kinase-associated protein 1A (p19A)
, RNA polymerase II elongation factor-like protein OCP2
, cyclin A/CDK2-associated p19
, cyclin A/CDK2-associated protein p19
, cyclin-A/CDK2-associated protein p19
, organ of Corti protein 2
, organ of Corti protein II
, transcription elongation factor B