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SKP1 Products

(S-Phase Kinase-Associated Protein 1 (SKP1))

Categories

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008].

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Featured SKP1 Categories

SKP1 Antibodies

High quality antibodies with extensive validation data.

SKP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

SKP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SKP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ICC, FACS, IHC, ELISA, WB
Validations
  • (1)
  • (6)
Cat. No. ABIN969397
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, FACS, IF, IHC (p), WB
Validations
  • (5)
Cat. No. ABIN5587970
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application EIA, FACS, IHC (p), WB
Validations
  • (5)
Cat. No. ABIN1109018
Quantity 0.1 mL
Datasheet Datasheet

Recommended SKP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959215
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381498
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN2685483
Quantity 1 kit
Datasheet Datasheet

Recommended SKP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1320087
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3095513
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3137493
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SKP1 products

Gu, Chen, Jin, Liu, Xu, Liu, Luo, Ling, Liu, Liu: "A Neonatal Mouse Model for Pressure Overload: Myocardial Response Corresponds to Severity." in: Frontiers in cardiovascular medicine, Vol. 8, pp. 660246, (2021) (PubMed).

Augustine, Chaudhary, Gupta, Islam, Ghosh, Santra, Mitra et al.: "Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCFcyclin F E3 Ligase ..." in: The Journal of biological chemistry, Vol. 292, Issue 13, pp. 5349-5363, (2017) (PubMed).

Mallampalli, Glasser, Coon, Chen: "Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis." in: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 663-73, (2013) (PubMed).

Werden, Lanchbury, Shattuck, Neff, Dufford, McFadden: "The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells." in: Journal of virology, Vol. 83, Issue 23, pp. 12068-83, (2009) (PubMed).

Wang, He, Wang, Wang, Zhai, Zhou, Zhang, Zhai, Feng, Han: "[Impact of Donor KIR2DS5 Genotype on Outcome Following Haploidentical Hematopoietic Stem Cell Transplantation.]" in: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 16, Issue 1, pp. 111-5, (2008) (PubMed).

Plesca, Mazumder, Gama, Matsuyama, Almasan: "A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron." in: The Journal of biological chemistry, Vol. 283, Issue 45, pp. 30796-803, (2008) (PubMed).

Shiraishi, Zhou, Aoki, Sato, Chiba, Tanaka, Yoshida, Nabeshima, Nabeshima, Tamura: "TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation." in: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9017-28, (2007) (PubMed).

Wu, Xu, Schulman, Jeffrey, Harper, Pavletich: "Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase." in: Molecular cell, Vol. 11, Issue 6, pp. 1445-56, (2003) (PubMed).

Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).

Piva, Liu, Chiarle, Podda, Pagano, Inghirami: "In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation." in: Molecular and cellular biology, Vol. 22, Issue 23, pp. 8375-87, (2002) (PubMed).

Synonyms and alternative names related to SKP1

S-phase kinase associated protein 1 (SKP1), S-phase kinase-associated protein 1 (skp1), S-phase kinase-associated protein 1 pseudogene (LOC100340043), S-phase kinase associated protein 1 (skp1), S-phase kinase-associated protein 1A (Skp1a), S-phase kinase-associated protein 1 (Skp1), S-phase kinase-associated protein 1 S homeolog (skp1.S), S-phase kinase-associated protein 1 (SKP1), S phase kinase-associated protein 1 (SKP1), S-phase kinase associated protein 1 (Skp1), 15kDa, 2610043E24Rik, 2610206H23Rik, ARABIDOPSIS SKP1 HOMOLOGUE 1, ASK1, ATSKP1, EMC19, emc19, ocp-2, OCP-II, ocp-ii, OCP2, ocp2, p19A, p19Skp1, SKP1, SKP1A, Skp1a, skp1a, S phase kinase-associated protein 1, T4O12.17, T4O12_17, TCEB1L, Tceb1l, tceb1l, UFO INTERACTING PROTEIN 1, UIP1, zgc:73186

Protein level used designations for SKP1

  • OCP-2
  • RNA polymerase II elongation factor-like protein OCP2
  • SIII
  • cyclin A/CDK2-associated p19
  • cyclin A/CDK2-associated protein p19
  • cyclin-A/CDK2-associated protein p19
  • organ of Corti protein 2
  • organ of Corti protein II
  • p19skp1
  • transcription elongation factor B
  • S-phase kinase-associated protein 1
  • SCF complex component
  • S-phase kinase-associated protein 1A
  • p19A
  • S-phase kinase-associated protein 1A (p19A)
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