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Browse our SMAD3 Proteins (SMAD3)

Full name:
SMAD, Mothers Against DPP Homolog 3 Proteins (SMAD3)
On are 27 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Proteins from 11 different suppliers available. Additionally we are shipping SMAD3 Antibodies (474) and SMAD3 Kits (54) and many more products for this protein. A total of 598 SMAD3 products are currently listed.
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all proteins Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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SMAD3 Proteins (SMAD3) by Origin

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Top referenced SMAD3 Proteins

  1. Human SMAD3 Protein expressed in Escherichia coli (E. coli) - ABIN666909 : Wang, Song, Sponseller, Danielpour: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN666909

More Proteins for SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Proteins) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Proteins)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Proteins)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 Proteins) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Proteins) provides insight into a novel Smad (show SMAD1 Proteins) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 Proteins)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Ang (show ANG Proteins) down-regulate the expression of Col (show HDAC1 Proteins)-I, alpha-SMA (show SMN1 Proteins) and TGF-beta1 (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins)/3 and subsequently inhibits fibroblast-myofibroblast transition.

  2. signal transducer and activator of transcription (Stat (show STAT1 Proteins))3 (show STAT3 Proteins) represses Smad3 in synergy with the potent negative regulators of TGF-beta (show TGFB1 Proteins) signaling, c-Ski (show SKI Proteins) and SnoN (show SKIL Proteins), whereby renders gefitinib-sensitive HCC827 cells resistant

  3. Therefore, our results demonstrate that autophagy counteracts the EndoMT process triggered by TGF-beta2 (show TGFB2 Proteins) by decreasing the phosphorylation level of Smad3.

  4. Conversely, siRNA-mediated Klotho (show KL Proteins) silencing up-regulated Egr-1 (show EGR1 Proteins), FN, and Col (show HDAC1 Proteins) I expression and the p-Smad3/Smad3 ratio. Moreover, the effects of si-Klotho (show KL Proteins) on Egr-1 (show EGR1 Proteins) expression were abolished by the TGF-beta1 (show TGFB1 Proteins) inhibitor SB-431542. Klotho (show KL Proteins) overexpression can prevent mesangial ECM (show MMRN1 Proteins) production in high-glucose-treated human MCs (show SMCP Proteins), an effect that has been partially attributed to Egr-1 (show EGR1 Proteins) down-regulation facilitated by TGF-beta1 (show TGFB1 Proteins)/Smad3 s...

  5. a novel STAT3 (show STAT3 Proteins)/SMAD3-signaling axis is required for OSM (show OSM Proteins)-mediated senescence.

  6. The protective (T) allele of rs17293632 disrupts a consensus AP-1 (show FOSB Proteins) binding site in a SMAD3 intron 1 enhancer, reduces enhancer activity and SMAD3 expression, altering human arterial smooth muscle cell proliferation to prevent coronary artery disease.

  7. Data suggest a novel role for TGFbeta1/TGFbeta receptor signaling via SMAD3 in regulation of expression of p16-Ink4a/Arf locus in beta-cells and highlight potential of using small molecule inhibitors of TGFbeta1/TGFbeta receptor signaling to promote human b-cell proliferation. (TGFbeta1 = transforming growth factor beta 1; p16-Ink4a = cyclin dependent kinase inhibitor 2A; SMAD3 = SMAD family member 3)

  8. TGF-beta (show TGFB1 Proteins)-treated fibroblasts contained SMAD (show SMAD1 Proteins) complexes that activated a SMAD (show SMAD1 Proteins) target gene in addition to those repressing PPARG (show PPARG Proteins) transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-beta (show TGFB1 Proteins) represses PPARG (show PPARG Proteins) transcription, thereby facilitating its own pro-fibrotic activity

  9. Our results suggested that miR (show MLXIP Proteins)-23a-3p contributes to OA progression by directly targeting SMAD3, providing a potential therapeutic target for OA treatment.

  10. Moreover, in PAH model, Smad3, p-Smad3 and Smad4 were all downregulated in lung tissues, and SIS3 (Smad3 inhibitor) could reverse the effects of anti-miR-199a-5p in PAH rats. Our date suggest that miR-199a-5p may function as a regulator of PAH by targeting Smad3, indicating a novel therapeutic strategy for patients with PAH.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2 (show SMAD2 Proteins)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 Proteins) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. gonadotropin-releasing hormone receptor (show GNRHR Proteins) mRNA levels were significantly elevated in knock-outs in both sexes. Interestingly, luteinizing hormone production was altered in a sex-specific fashion. Overall, our analyses demonstrate that SMAD3 is required for FSH (show BRD2 Proteins) synthesis in vivo

  2. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

  3. hese studies revealed that Smad2 (show SMAD2 Proteins) plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH Proteins) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  4. emodin was found to increase the expression level of Sirt1 (show SIRT1 Proteins), which decreased the level of deacetylated Smad3 to attenuate collagen deposition. Furthermore, the data suggested that there was direct binding between emodin and Sirt1 (show SIRT1 Proteins). Sirt1regulated TGFb1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling was involved in silica inhalationinduced lung fibrosis.

  5. HSP27 (show HSPB1 Proteins) expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 (show HSPB1 Proteins) modulates lung fibroblast differentiation through the Smad3 and ERK (show EPHB2 Proteins) pathways.

  6. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1 (show TGFB1 Proteins)/Smad3 signaling pathway.

  7. Notch3 (show NOTCH3 Proteins) is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 (show NOTCH3 Proteins) is attributable to its action on TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling.

  8. Smad3 deficiency leads to aortic aneurysms and sudden death in the Smad3 knockout animal model.

  9. TGF-beta1 (show TGFB1 Proteins)-induced inhibition of PPARgamma (show PPARG Proteins) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 (show HDAC1 Proteins) at the PPARgamma (show PPARG Proteins) promoter.

  10. Activation of CB2 (show CNR2 Proteins) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Proteins)-mediated inhibition of TGF-beta1 (show TGFB1 Proteins)/Smad3 pathway in mice with myocardial infarction.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Proteins)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Proteins)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD3 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3)
  • MAD homolog 3a (Drosophila) (smad3a)
  • mothers against decapentaplegic homolog 3 (LOC100346303)
  • SMAD family member 3 (smad3)
  • SMAD family member 3 (Smad3)
  • AU022421 protein
  • HSPC193 protein
  • HsT17436 protein
  • JV15-2 protein
  • LDS1C protein
  • LDS3 protein
  • mad3 protein
  • Madh3 protein
  • madh3-A protein
  • madh3a protein
  • Smad 3 protein
  • smad3 protein
  • wu:fa99e03 protein
  • XenMLP protein
  • Xmad3 protein
  • XSmad3 protein

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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