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Browse our SMAD3 Proteins (SMAD3)

Full name:
SMAD, Mothers Against DPP Homolog 3 Proteins (SMAD3)
On www.antibodies-online.com are 25 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Proteins from 12 different suppliers available. Additionally we are shipping SMAD3 Antibodies (476) and SMAD3 Kits (46) and many more products for this protein. A total of 590 SMAD3 products are currently listed.
Synonyms:
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all proteins Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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SMAD3 Proteins (SMAD3) by Origin

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Top referenced SMAD3 Proteins

  1. Human SMAD3 Protein expressed in Escherichia coli (E. coli) - ABIN666909 : Wang, Song, Sponseller, Danielpour: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN666909

More Proteins for SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Proteins) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Proteins)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Proteins)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 Proteins) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Proteins) provides insight into a novel Smad (show SMAD1 Proteins) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 Proteins)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. SMAD3 mutations reported in patients with syndromic Aortic Aneurisms and dissections with early-onset osteoarthritis.

  2. The results also revealed the existence of crosstalk between miR (show MLXIP Proteins)-29b and TGF-beta1 (show TGFB1 Proteins)/Smad3 during LX-2 activation, suggesting a feedback loop between miR (show MLXIP Proteins)-29b and TGF-beta1 (show TGFB1 Proteins)/Smad3 signalling that promotes liver fibrosis.

  3. Smad2 (show SMAD2 Proteins) and Smad3 possess differential sensitivities in relaying TGFbeta (show TGFB1 Proteins) signaling and have distinct roles in regulating early developmental events.

  4. Likely pathogenic variants included a TGFB2 (show TGFB2 Proteins) variant in one patient and a SMAD3 variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK (show MYLK Proteins) and MFAP5 (show MFAP5 Proteins), which were identified in a third patient

  5. The more significant compound effects of two-locus models, combining single nucleotide polymorphisms (SNPs) in ADAM17 (show ADAM17 Proteins) and other TGF-beta (show TGFB1 Proteins) signaling pathway genes including TGFB2 (show TGFB2 Proteins) and SMAD3, on KD phenotypes relative to single SNPs suggest that ADAM17 (show ADAM17 Proteins) is also involved in secondary CAL (show FBLIM1 Proteins) formation and confers the risk of KD/CALs (show CA8 Proteins) via the TGF-beta (show TGFB1 Proteins)/SMAD3 signaling pathway.

  6. Exogenous expression of miR (show MLXIP Proteins)-142-5p inhibitor resulted in a significant reduction of viral titer indicating proviral role of miR (show MLXIP Proteins)-142-5p. Functional studies of hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-142-5p identified its role in transforming growth factor beta (TGFbeta (show TGFB1 Proteins)) signalling as TGFbeta (show TGFB1 Proteins) receptor 2 and SMAD3 were degraded during both hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-142-5p overexpression and rotavirus infection.

  7. These findings pinpoint that TGF-beta (show TGFB1 Proteins) represses miR (show MLXIP Proteins)-30d through a Smad2 (show SMAD2 Proteins)/3-HDAC3 (show HDAC3 Proteins)-NCoR (show NCOR1 Proteins) repression complex and provide novel insights into a potential target for the treatment of podocyte injury-associated glomerulopathies.

  8. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

  9. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (show WNT2 Proteins) pathway, and inhibition of Smad2 (show SMAD2 Proteins)/3 signaling and Shh (show SHH Proteins) pathways.

  10. Our study demonstrates that SMAD3 is significantly overexpressed in osteoarthritis. This overexpression cannot be explained by DNA methylation (show HELLS Proteins) in the promoter region.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2 (show SMAD2 Proteins)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 Proteins) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Activation of CB2 (show CNR2 Proteins) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Proteins)-mediated inhibition of TGF-beta1 (show TGFB1 Proteins)/Smad3 pathway in mice with myocardial infarction.

  2. This study found evidence of increased leukocyte phosphorylated-Smad2 (show SMAD2 Proteins)/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 Proteins).

  3. The findings indicate that active Yap1 (show YAP1 Proteins) promotes the self-renewal of breast Tumor initiating cells by inhibiting Smad3 signaling.

  4. Data show that muscle-specific (show EIF3K Proteins) Smad (show SMAD1 Proteins) proteins Smad2 (show SMAD2 Proteins)/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  5. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2 (show SMAD2 Proteins)/3 activity during murine cardiac progenitor cell differentiation.

  6. This study showed that Smad3 deficiency inhibits LTP (show SCP2 Proteins) induction by enhancing phasic and tonic GABAA (show GABRg1 Proteins) receptor-mediated neurotransmission.

  7. Suggest that hyperoxia-increased high-tidal-volume ventilation-induced acute lung injury partially depends on the Src (show SRC Proteins) and Smad3 pathways.

  8. Smad3 is a key transcriptional factor of TGF-beta (show TGFB1 Proteins) signaling that differentially regulates T cell immune responses in a mouse model of cardiac allograft rejection

  9. Smad2 (show SMAD2 Proteins) and Smad3 oppositely modify STAT3 (show STAT3 Proteins)-induced transcription of IL-17A (show IL17A Proteins) and retinoic acid receptor (show RARA Proteins)-related orphan nuclear receptor (show NR1D1 Proteins), RORgammat encoded by Rorc (show RORC Proteins), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Proteins), respectively.

  10. Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P (show S1PR1 Proteins))/S1P3 (show S1PR3 Proteins) signaling axis

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Proteins)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Proteins)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD3 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3)
  • MAD homolog 3a (Drosophila) (smad3a)
  • mothers against decapentaplegic homolog 3 (LOC100346303)
  • SMAD family member 3 (smad3)
  • SMAD family member 3 (Smad3)
  • AU022421 protein
  • HSPC193 protein
  • HsT17436 protein
  • JV15-2 protein
  • LDS1C protein
  • LDS3 protein
  • mad3 protein
  • Madh3 protein
  • madh3-A protein
  • madh3a protein
  • Smad 3 protein
  • smad3 protein
  • wu:fa99e03 protein
  • XenMLP protein
  • Xmad3 protein
  • XSmad3 protein

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

GENE ID SPECIES
100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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