Browse our SMAD3 Proteins (SMAD3)

Full name:
SMAD, Mothers Against DPP Homolog 3 Proteins (SMAD3)
On are 27 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Proteins from 11 different suppliers available. Additionally we are shipping SMAD3 Antibodies (515) and SMAD3 Kits (57) and many more products for this protein. A total of 642 SMAD3 products are currently listed.
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all proteins Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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SMAD3 Proteins (SMAD3) by Origin

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Top referenced SMAD3 Proteins

  1. Human SMAD3 Protein expressed in Escherichia coli (E. coli) - ABIN666909 : Wang, Song, Sponseller, Danielpour: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for 666909

More Proteins for SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data suggest that Clock1a (show CLOCK Proteins) coordinates mesoderm development and primitive hematopoiesis in embryos by up-regulating Nodal-Smad3 signaling; Clock1a (show CLOCK Proteins) alterations produce embryonic defects with shortened body length, lack of ventral tail fin, or partial defect of the eyes; Clock1a (show CLOCK Proteins) activates Smad3a promoter via its E-box1 element. (Clock1a (show CLOCK Proteins) = clock circadian regulator (show CLOCK Proteins) a; Nodal = nodal modulator 1 (show NOMO1 Proteins); Smad3a = SMAD (show SMAD1 Proteins) family member 3a)

  2. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Proteins) control of zebrafish spinal cord development

  3. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Proteins)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Proteins)/3 signaling and embryonic patterning.

  4. although the role of Smad (show SMAD1 Proteins) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Proteins) provides insight into a novel Smad (show SMAD1 Proteins) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  5. Smad2 (show SMAD2 Proteins)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. TF-induced microvessel stabilization is regulated via PAR2 (show F2RL1 Proteins)-SMAD3 that is indispensable for the maintenance of vascular integrity.

  2. cPLA2alpha (show PLA2G4A Proteins) activates PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and inhibits Smad2 (show SMAD2 Proteins)/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.

  3. stablish PPM1A (show PPM1A Proteins) as a novel repressor of the SMAD3 pathway in renal fibrosis

  4. Methylation in SMAD3 was selectively increased in asthmatic children of asthmatic mothers and was associated with childhood asthma risk

  5. a direct crosstalk between the STAT3 (show STAT3 Proteins) and Smad3 signaling pathways that may contribute to tumor development and inflammation.

  6. It is reported here that TGF-beta (show TGFB1 Proteins) directly regulates alternative splicing of cancer stem cell marker CD44 (show CD44 Proteins) through a phosphorylated threonine179 of SMAD3-mediated interaction with RNA-binding protein (show PTBP1 Proteins) PCBP1 (show PCBP1 Proteins).

  7. Bcl-3 (show BCL3 Proteins) knockdown enhanced the degradation of Smad3 but not Smad2 (show SMAD2 Proteins) following TGFbeta (show TGFB1 Proteins) treatment.

  8. miR (show MLXIP Proteins)-206 and miR (show MLXIP Proteins)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 (show TRIB2 Proteins) promoter activity through p-Smad3.

  9. These studies support previously unrecognized, cooperative interaction between the CCN1 (show CCNA2 Proteins) matricellular protein and canonical TGF-beta1 (show TGFB1 Proteins)/SMAD3 signaling that promotes lung fibrosis.

  10. c-Abl (show ABL1 Proteins) promotes TGF-beta (show TGFB1 Proteins)-induced SKIP/Smad3 interaction.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2 (show SMAD2 Proteins)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Activin A (show INHBA Proteins) and overexpression of SMAD2 (show SMAD2 Proteins)/3 significantly promoted expressions of porcine NANOG (show NANOG Proteins) and OCT4 (show POU5F1 Proteins),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (show NANOG Proteins)/OCT4 (show POU5F1 Proteins) expression.

  2. Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

  3. SP1 (show SP1 Proteins) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. The results uncover an important aspect of the cross-talk between TGFbeta (show TGFB1 Proteins) and Hippo signaling, showing that TGFbeta (show TGFB1 Proteins) induces TAZ (show TAZ Proteins) via a Smad3-independent, p38 (show CRK Proteins)- and MRTF-mediated and yet MRTF translocation-independent mechanism.

  2. Data suggest that Gas5 suppresses Tgfb1 (show TGFB1 Proteins)/Smad3 signaling in vascular smooth muscle cell differentiation from mesenchymal progenitor cells; Gas5 competitively binds Smad3 via multiple RNA Smad (show SMAD1 Proteins)-binding elements. (Gas5 = growth arrest-specific 5 long non-coding RNA; Tgfb1 (show TGFB1 Proteins) = transforming growth factor beta 1 (show TGFB1 Proteins); Smad3 = MAD homolog 3 protein)

  3. point mutant that was unable to bind pSMAD3 proved ineffective. These findings indicate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferative actions of TGF-beta (show TGFB1 Proteins).

  4. Soluble epoxide hydrolase (show EPHX2 Proteins) inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38 (show CRK Proteins)/Smad3 signaling pathway.

  5. A critical role for the Smad3-c-Jun (show JUN Proteins) pathway in the regulation of Fstl1 (show FSTL1 Proteins).

  6. Mirtazapine suppressed 5-HT-mediated TGF-beta1/Smad3 and ERK1/2 signaling pathways as well as oxidative stress that contribute to the progression of liver fibrosis.

  7. These results suggest that Nedd9 (show NEDD9 Proteins) is a Smad2 (show SMAD2 Proteins)/3 target gene implicated in RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.

  8. These results suggested that TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling was activated during CCl4 (show CCL4 Proteins)-induced acute liver injury in mice, and Smad3 overexpression aggravated acute liver injury by promoting inflammatory cells infiltration, inflammatory cytokines release and hepatocytes apoptosis.

  9. gonadotropin-releasing hormone receptor (show GNRHR Proteins) mRNA levels were significantly elevated in knock-outs in both sexes. Interestingly, luteinizing hormone production was altered in a sex-specific fashion. Overall, our analyses demonstrate that SMAD3 is required for FSH (show BRD2 Proteins) synthesis in vivo

  10. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Proteins)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Proteins)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD3 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3)
  • MAD homolog 3a (Drosophila) (smad3a)
  • mothers against decapentaplegic homolog 3 (LOC100346303)
  • SMAD family member 3 (smad3)
  • SMAD family member 3 (Smad3)
  • AU022421 protein
  • HSPC193 protein
  • HsT17436 protein
  • JV15-2 protein
  • LDS1C protein
  • LDS3 protein
  • mad3 protein
  • Madh3 protein
  • madh3-A protein
  • madh3a protein
  • Smad 3 protein
  • smad3 protein
  • wu:fa99e03 protein
  • XenMLP protein
  • Xmad3 protein
  • XSmad3 protein

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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