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Browse our SMAD3 Proteins (SMAD3)

Full name:
SMAD, Mothers Against DPP Homolog 3 Proteins (SMAD3)
On are 24 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Proteins from 12 different suppliers available. Additionally we are shipping SMAD3 Antibodies (460) and SMAD3 Kits (47) and many more products for this protein. A total of 574 SMAD3 products are currently listed.
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all proteins Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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SMAD3 Proteins (SMAD3) by Origin

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Top referenced SMAD3 Proteins

  1. Human SMAD3 Protein expressed in Escherichia coli (E. coli) - ABIN666909 : Wang, Song, Sponseller, Danielpour: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN666909

More Proteins for SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Proteins) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Proteins)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Proteins)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 Proteins) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Proteins) provides insight into a novel Smad (show SMAD1 Proteins) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 Proteins)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. results demonstrated that the novel pathway H19 (show NCKAP1 Proteins)/miR (show MLXIP Proteins)-675/TGF-beta1 (show TGFB1 Proteins)/Smad3/HDAC (show HDAC3 Proteins) regulates osteogenic differentiation of hMSCs and may serve as a potential target for enhancing bone formation in vivo.

  2. Induction of pSmad3L through BLT1-NOX-ROS (show ROS1 Proteins)-EGFR (show EGFR Proteins)-PI3K (show PIK3CA Proteins)-ERK1/2 signaling pathway is a key mechanism by which LTB4 (show PTGR1 Proteins) blocks the anti-proliferative responses of TGF-beta1 (show TGFB1 Proteins) in breast tumors.

  3. results indicate that miR-16 (show GDE1 Proteins)-5p is an important regulator of SMAD3 expression in human chondrocytes and may contribute to the development of osteoarthritis

  4. Up-regulation of smad3 is associated with endometrial cancer.

  5. SMAD3 is a necessary factor for TGFbeta (show TGFB1 Proteins)-mediated stimulation of mRNA and protein expression of type IV collagen (show COL4 Proteins) genes in human vascular smooth muscle cells; it regulates expression of COL4a1 (show COL4A1 Proteins) and COL4a2 (show COL4a2 Proteins)

  6. These results for the first time demonstrate a role of Cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) in the regulation of cell cycle progression modulated by TGF-beta1 (show TGFB1 Proteins).

  7. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation

  8. Data show that the expression of transforming growth factor beta 1 (TGFB1 (show TGFB1 Proteins)) was correlated with the expression of SMA- and MAD-related protein 3 (SMAD3) and matrix metalloproteinase-13 (MMP13 (show MMP13 Proteins)) in osteoarthritis (OA)-affected cartilage.

  9. Different signaling pathways are involved in osteitis in CRS (show CARS Proteins) and are activated by the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling pathway in CRSwNP versus the TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins)-independent signaling pathway in CRSsNP.

  10. Astragaloside can delay the renal fibrosis process in diabetic mice by influencing the TGF-beta (show TGFB1 Proteins)/SMADS signaling pathway and down-regulating TGF-beta1 (show TGFB1 Proteins), SMAD2 (show SMAD2 Proteins)/3, and alpha-SMA (show SMN1 Proteins) expression.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2 (show SMAD2 Proteins)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 Proteins) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2 (show SMAD2 Proteins)/3 activity during murine cardiac progenitor cell differentiation.

  2. This study showed that Smad3 deficiency inhibits LTP (show SCP2 Proteins) induction by enhancing phasic and tonic GABAA (show GABRg1 Proteins) receptor-mediated neurotransmission.

  3. Suggest that hyperoxia-increased high-tidal-volume ventilation-induced acute lung injury partially depends on the Src (show SRC Proteins) and Smad3 pathways.

  4. Smad3 is a key transcriptional factor of TGF-beta (show TGFB1 Proteins) signaling that differentially regulates T cell immune responses in a mouse model of cardiac allograft rejection

  5. Smad2 (show SMAD2 Proteins) and Smad3 oppositely modify STAT3 (show STAT3 Proteins)-induced transcription of IL-17A (show IL17A Proteins) and retinoic acid receptor (show RARA Proteins)-related orphan nuclear receptor (show NR1D1 Proteins), RORgammat encoded by Rorc (show RORC Proteins), by acting as a co-activator and co-repressor of STAT3 (show STAT3 Proteins), respectively.

  6. Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P (show S1PR1 Proteins))/S1P3 (show S1PR3 Proteins) signaling axis

  7. pSmad3L-Ser (show SIGLEC1 Proteins) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (show TRH Proteins) immunostaining-positive cells are cancer

  8. SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.

  9. These results suggest that TGF-beta regulates RANKL-induced osteoclastogenesis through reciprocal cooperation between Smad2/3 and c-Fos.

  10. Treatment with geniposide almost completely blocked the phosphorylation of Smad2 (show SMAD2 Proteins)/3, extracellular signal-regulated kinase (ERK (show EPHB2 Proteins)) and Akt (show AKT1 Proteins) in AML12 cells.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Proteins)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Proteins)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD3 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3)
  • MAD homolog 3a (Drosophila) (smad3a)
  • mothers against decapentaplegic homolog 3 (LOC100346303)
  • SMAD family member 3 (smad3)
  • SMAD family member 3 (Smad3)
  • AU022421 protein
  • HSPC193 protein
  • HsT17436 protein
  • JV15-2 protein
  • LDS1C protein
  • LDS3 protein
  • mad3 protein
  • Madh3 protein
  • madh3-A protein
  • madh3a protein
  • Smad 3 protein
  • smad3 protein
  • wu:fa99e03 protein
  • XenMLP protein
  • Xmad3 protein
  • XSmad3 protein

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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