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Browse our SMAD3 Proteins (SMAD3)

Full name:
SMAD, Mothers Against DPP Homolog 3 Proteins (SMAD3)
On www.antibodies-online.com are 28 SMAD, Mothers Against DPP Homolog 3 (SMAD3) Proteins from 12 different suppliers available. Additionally we are shipping SMAD3 Antibodies (490) and SMAD3 Kits (51) and many more products for this protein. A total of 612 SMAD3 products are currently listed.
Synonyms:
AU022421, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, mad3, Madh3, madh3-A, madh3a, Smad 3, smad3, wu:fa99e03, XenMLP, Xmad3, XSmad3
list all proteins Gene Name GeneID UniProt
SMAD3 4088 P84022
SMAD3 17127 Q8BUN5
SMAD3 25631 P84025

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SMAD3 Proteins (SMAD3) by Origin

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Top referenced SMAD3 Proteins

  1. Human SMAD3 Protein expressed in Escherichia coli (E. coli) - ABIN666909 : Wang, Song, Sponseller, Danielpour: Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. in The Journal of biological chemistry 2005 (PubMed)
    Show all 2 references for ABIN666909

More Proteins for SMAD3 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 is mainly active in post-mitotic, non-proliferating cells with a role in TGF-beta (show TGFB1 Proteins) control of zebrafish spinal cord development

  2. Nodal signaling and mesendoderm induction depend on Smad2 (show SMAD2 Proteins)/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2 (show SMAD2 Proteins)/3 signaling and embryonic patterning.

  3. although the role of Smad (show SMAD1 Proteins) proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap (show TDP2 Proteins) provides insight into a novel Smad (show SMAD1 Proteins) partner that plays an essential role in the fine-tuning of this signal transduction cascade

  4. Smad2 (show SMAD2 Proteins)/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Rabbit SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling pathway in chronic heart failure .

  2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

Human SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2F5/p38 (show CRK Proteins) axis played a cardinal (show CARD8 Proteins) role in uncontrolled cellular proliferation in prostate cancer through pSMAD3L activation.

  2. hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-497-5p is a negative regulator of SMAD3 gene.

  3. Knockdown of PTTG1 (show PTTG1 Proteins) suppresses the growth and invasion of LAC (show LCT Proteins) cells through upregulation of the TGFbeta1 (show TGFB1 Proteins)/SMAD3 signaling.

  4. HSP27 (show HSPB1 Proteins) expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 (show HSPB1 Proteins) modulates lung fibroblast differentiation through the Smad3 and ERK (show EPHB2 Proteins) pathways.

  5. hypoxia facilitates the transition of dermal fibroblasts to myofibroblasts through the activation of the TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling pathway.

  6. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1 (show TGFB1 Proteins)/Smad3 signaling pathway.

  7. SMAD3 was identified as a direct target gene of miR (show MLXIP Proteins)-708, and functional analysis demonstrated that miR (show MLXIP Proteins)-708 could markedly suppress osteogenic differentiation and adipogenesis differentiation of MSCs

  8. overexpression of miR29b markedly reduced the expression levels of COL1A1 (show COL1A1 Proteins) and alphaSMA (show ACTA2 Proteins), and decreased the expression and nuclear accumulation of pSmad2/3.

  9. p-SMAD2 (show SMAD2 Proteins)/3 proteins were remarkably increased in bladder carcinoma. High p-SMAD2 (show SMAD2 Proteins)/3 was not statistically associated with clinicopathological characteristics of the patients. Overexpression of hepaCAM (show HEPACAM Proteins) prevented the p-SMAD2 (show SMAD2 Proteins)/3 translocation from the cytoplasm to the nucleus in bladder cancer cells. The p-SMAD2 (show SMAD2 Proteins)/3 pathway is critical for hepaCAM (show HEPACAM Proteins)-induced cancer cell apoptosis.

  10. The results of the present study suggested that Rac1 enhanced the expression of Smad3/4 in activated hepatic stellate cells; however, this increase may be suppressed by SAM-induced methylation of Rac1 promoters.

Xenopus laevis SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. E2a (show TCF3 Proteins) is necessary to drive transcription of Smad2 (show SMAD2 Proteins)/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

Pig (Porcine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial-myofibroblast transition

  2. SP1 (show SP1 Proteins) and SMAD3 are required for high glucose-induced p21(WAF1 (show CDKN1A Proteins)) gene transcription in LLC-PK1 (show PKLR Proteins) cells.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. hese studies revealed that Smad2 (show SMAD2 Proteins) plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH Proteins) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  2. emodin was found to increase the expression level of Sirt1 (show SIRT1 Proteins), which decreased the level of deacetylated Smad3 to attenuate collagen deposition. Furthermore, the data suggested that there was direct binding between emodin and Sirt1 (show SIRT1 Proteins). Sirt1regulated TGFb1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling was involved in silica inhalationinduced lung fibrosis.

  3. HSP27 (show HSPB1 Proteins) expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 (show HSPB1 Proteins) modulates lung fibroblast differentiation through the Smad3 and ERK (show EPHB2 Proteins) pathways.

  4. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1 (show TGFB1 Proteins)/Smad3 signaling pathway.

  5. Notch3 (show NOTCH3 Proteins) is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 (show NOTCH3 Proteins) is attributable to its action on TGF-beta1 (show TGFB1 Proteins)/Smad3 signaling.

  6. Smad3 deficiency leads to aortic aneurysms and sudden death in the Smad3 knockout animal model.

  7. TGF-beta1 (show TGFB1 Proteins)-induced inhibition of PPARgamma (show PPARG Proteins) transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 (show HDAC1 Proteins) at the PPARgamma (show PPARG Proteins) promoter.

  8. Activation of CB2 (show CNR2 Proteins) ameliorates myocardial fibrosis via Nrf2 (show NFE2L2 Proteins)-mediated inhibition of TGF-beta1 (show TGFB1 Proteins)/Smad3 pathway in mice with myocardial infarction.

  9. This study found evidence of increased leukocyte phosphorylated-Smad2 (show SMAD2 Proteins)/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 Proteins).

  10. The findings indicate that active Yap1 (show YAP1 Proteins) promotes the self-renewal of breast Tumor initiating cells by inhibiting Smad3 signaling.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 3 (SMAD3) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2 (show SMAD2 Proteins)/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2 (show SMAD2 Proteins)/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD3 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Alternative names and synonyms associated with SMAD3

  • SMAD family member 3 (SMAD3)
  • MAD homolog 3a (Drosophila) (smad3a)
  • mothers against decapentaplegic homolog 3 (LOC100346303)
  • SMAD family member 3 (smad3)
  • SMAD family member 3 (Smad3)
  • AU022421 protein
  • HSPC193 protein
  • HsT17436 protein
  • JV15-2 protein
  • LDS1C protein
  • LDS3 protein
  • mad3 protein
  • Madh3 protein
  • madh3-A protein
  • madh3a protein
  • Smad 3 protein
  • smad3 protein
  • wu:fa99e03 protein
  • XenMLP protein
  • Xmad3 protein
  • XSmad3 protein

Protein level used designations for SMAD3

MAD homolog 3 , MAD homolog 3a , MAD, mothers against decapentaplegic homolog 3 , SMA- and MAD-related protein 3 , SMAD, mothers against DPP homolog 3 , hMAD-3 , hSMAD3 , mad homolog JV15-2 , mad protein homolog , mad3 , mothers against DPP homolog 3 , mothers against decapentaplegic homolog 3 , SMAD 3 , TGF beta response effector Smad3 , TGF-beta response effector Smad3 , Smad 3 , mMad3 , MAD (mothers against decapentaplegic, Drosophila) homolog 3 , SMAD family member 3

GENE ID SPECIES
100033845 Equus caballus
58092 Danio rerio
100346303 Oryctolagus cuniculus
4088 Homo sapiens
378633 Xenopus laevis
395132 Gallus gallus
610902 Canis lupus familiaris
397260 Sus scrofa
17127 Mus musculus
25631 Rattus norvegicus
515125 Bos taurus
100731807 Cavia porcellus
443169 Ovis aries
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