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Browse our SMAD4 Proteins (SMAD4)

Full name:
SMAD Family Member 4 Proteins (SMAD4)
On are 22 SMAD Family Member 4 (SMAD4) Proteins from 13 different suppliers available. Additionally we are shipping SMAD4 Antibodies (162) and SMAD4 Kits (43) and many more products for this protein. A total of 249 SMAD4 products are currently listed.
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all proteins Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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SMAD4 Proteins (SMAD4) by Origin

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Top referenced SMAD4 Proteins

  1. Human SMAD4 Protein expressed in Escherichia coli (E. coli) - ABIN666874 : de Caestecker, Hemmati, Larisch-Bloch, Ajmera, Roberts, Lechleider: Characterization of functional domains within Smad4/DPC4. in The Journal of biological chemistry 1997 (PubMed)
    Show all 2 references for ABIN666874

  2. Human SMAD4 Protein expressed in Wheat germ - ABIN1320605 : Iempridee, Das, Xu, Mertz: Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene. in Journal of virology 2011 (PubMed)

More Proteins for SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. we discovered a novel mechanism mediated by Smad4 to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/CDC2 (show CDK1 Proteins)/survivin (show BIRC5 Proteins) cascade.

  2. Study shows the upregulation of miR (show MLXIP Proteins)-130a and inactivation of Smad4 in gemcitabine resistant hepatocellular carcinoma cells, (HCC (show FAM126A Proteins)) and describes a potential mechanism for dysregulation of Smad4 by miR (show MLXIP Proteins)-130a-3p in HCC (show FAM126A Proteins).

  3. Loss of SMAD4 was significantly associated with CCL15 (show CCL15 Proteins) expression.

  4. germline SMAD4 gene mutation is associated with gastric polyposis.

  5. The reverse correlation of Jab1 (show COPS5 Proteins) and Smad4 in PANC-1 cells may be involved in the Pathogenesis of prostate cancer. Jab1 (show COPS5 Proteins) can cause degradation of Smad4 via TGF-beta (show TGFB1 Proteins) signal pathway.

  6. data suggest that TGF-beta1 (show TGFB1 Proteins) enhances IGFBP7 (show IGFBP7 Proteins) via Smad2 (show SMAD2 Proteins)/4 pathways, and that IGFBP7 (show IGFBP7 Proteins) might be involved in the TGF-beta1 (show TGFB1 Proteins)-induced tubular injury in DN.

  7. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  8. Microarray analysis of gene expression at 8, 24, and 48 hours after SMAD4 expression characterized the regulatory impact of SMAD4 expression in a SMAD4-null pancreatic ductal adenocarcinoma cell line and identified novel targets of TGF-beta (show TGFB1 Proteins) signaling.

  9. Transcription factor SMAD4 (a part of the TGF-beta (show TGFB1 Proteins) signaling pathway) activates Fn14 (show TNFRSF12A Proteins) expression. Then, activated Fn14 (show TNFRSF12A Proteins) expression increases extracellular matrix synthesis and fibroblast activation.

  10. In operated pancreatic adenocarcinoma, incidence of mutations was: SMAD4 = 20%.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Smad4 deficiency led to aberrant transcriptional programs in antigen-specific CD8 (show CD8A Proteins)(+) T cells. Findings demonstrated an essential role of Smad4 in the control of effector and memory CD8 (show CD8A Proteins)(+) T-cell responses to infection.

  2. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-induced changes in Gata2 transcription factor (show GATA2 Proteins) and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C Proteins)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Proteins) signaling via Smad4 protein.

  3. Smad4 knockdown blocks the effects of miR (show MLXIP Proteins)-144-3p inhibitor. MiR (show MLXIP Proteins)-144-3p negatively regulates osteogenic differentiation and proliferation of C3H10T1/2 cells by targeting Smad4.

  4. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  5. Smad4-dependent TGF-beta (show TGFB1 Proteins) signaling in smooth muscle cells protects against aortic aneurysm formation and dissection.

  6. the interplay between TGFalpha and TGF-beta (show TGFB1 Proteins) signaling in pancreatic tumorigenesis

  7. The findings suggest that Smad4 is essential for initiating the ureteral smooth muscle cell differentiation program during ureter development.

  8. During high-fat diet, fed and fasting blood glucose levels, glucose stimulated insulin (show INS Proteins) secretion, disposition index and glucose tolerance were significantly improved in beta-Smad4KO mice as compared with wild-type mice.

  9. This study showed that Smad4 in the oocyte is not required for oocyte or follicle development, ovulation, fertilization, preimplantation development (show MTA2 Proteins), or implantation.

  10. The results of this study suggest that Smad4 knockdown is one of the crucial therapeutic options for the prevention of renal fibrosis in vivo

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  2. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Proteins).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Proteins) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 Proteins) and Smad4 have roles in TGF-beta1 (show TGFB1 Proteins)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 Proteins) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Protein Profile

Protein Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4)
  • Smad4 protein (smad4)
  • mothers against decapentaplegic homolog 4 (LOC100342294)
  • SMAD family member 4 (Smad4)
  • SMAD family member 4, gene 1 (smad4.1)
  • AW743858 protein
  • D18Wsu70e protein
  • dpc4 protein
  • jip protein
  • madh4 protein
  • MYHRS protein
  • smad4 protein
  • Xsmad4 protein
  • xsmad4a protein
  • XSmad4alpha protein

Protein level used designations for SMAD Family Member 4 Proteins (SMAD4)

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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