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Browse our SMAD4 Proteins (SMAD4)

Full name:
SMAD Family Member 4 Proteins (SMAD4)
On are 22 SMAD Family Member 4 (SMAD4) Proteins from 13 different suppliers available. Additionally we are shipping SMAD4 Antibodies (166) and SMAD4 Kits (39) and many more products for this protein. A total of 248 SMAD4 products are currently listed.
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all proteins Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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SMAD4 Proteins (SMAD4) by Origin

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Top referenced SMAD4 Proteins

  1. Human SMAD4 Protein expressed in Escherichia coli (E. coli) - ABIN666874 : de Caestecker, Hemmati, Larisch-Bloch, Ajmera, Roberts, Lechleider: Characterization of functional domains within Smad4/DPC4. in The Journal of biological chemistry 1997 (PubMed)
    Show all 2 references for ABIN666874

  2. Human SMAD4 Protein expressed in Wheat germ - ABIN1320605 : Iempridee, Das, Xu, Mertz: Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene. in Journal of virology 2011 (PubMed)

  3. Human SMAD4 Protein expressed in HEK-293 Cells - ABIN2732222 : Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016 (PubMed)

More Proteins for SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. SENP1 (show SENP1 Proteins) deSUMOylated SMAD4 to promote EMT (show ITK Proteins) via up-regulating E-cadherin (show CDH1 Proteins) in prostate cancer cells. Therefore, SENP1 (show SENP1 Proteins) is a potential target for treatment of advanced prostate cancer.

  2. TGF-beta (show TGFB1 Proteins)-treated fibroblasts contained SMAD (show SMAD1 Proteins) complexes that activated a SMAD (show SMAD1 Proteins) target gene in addition to those repressing PPARG (show PPARG Proteins) transcription, the first finding of such dual activity within the same cell. These findings describe in detail novel mechanisms by which TGF-beta (show TGFB1 Proteins) represses PPARG (show PPARG Proteins) transcription, thereby facilitating its own pro-fibrotic activity

  3. The 1244_1247delACAG mutation of SMAD4 is the cause of juvenile polyposis syndrome and the likely cause of Menetrier's disease (MD) in a large family initially diagnosed with MD.

  4. The nuclear importin (show KPNA4 Proteins) IPO5 (show IPO5 Proteins) was identified as a novel interacting protein of SMAD1 (show GARS Proteins). Overexpression of IPO5 (show IPO5 Proteins) in various cell lines specifically increases nuclear localization of BMP receptor (show BMPR1A Proteins)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (show IPO5 Proteins) and BMP but not TGF-beta (show TGFB1 Proteins) R-SMADs.

  5. The phenotype of juvenile polyposis syndrome with hereditary hemorrhagic telangiectasia caused by the SMAD4 mutations has been described.

  6. Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia reveal paucity of alterations in TP53 (show TP53 Proteins) and SMAD4 as opposed to pancreatic ductal adenocarcinoma.

  7. Loss of heterozygosity of TP53 (show TP53 Proteins), P16, SMAD4 and APC (show APC Proteins) genes was observed in esophageal adenocarcinoma.

  8. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (show VEGFC Proteins) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  9. In this study, we confirmed that overexpression of miR205 suppressed the expression of Smad4, in turn, weakened the TGF-b/Smad (show SMAD1 Proteins) signaling pathway and inhibited TGF-b/Smad4-induced EMT (show ITK Proteins), invasion and migration ultimately.

  10. A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 Proteins) and both zeta-chain-associated protein kinase (show CDK7 Proteins) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (show SMAD2 Proteins)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS Proteins)/8 and lower SMAD-4 expression in chronic lymphocytic leukemia cells

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells.

  2. Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 (show BMP2 Proteins) to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4 (show ATF4 Proteins).

  3. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (show VEGFC Proteins) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  4. MZF1 (show ZSCAN1 Proteins) has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1 (show ZSCAN1 Proteins)-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  5. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

  6. Smad4 deficiency led to aberrant transcriptional programs in antigen-specific CD8 (show CD8A Proteins)(+) T cells. Findings demonstrated an essential role of Smad4 in the control of effector and memory CD8 (show CD8A Proteins)(+) T-cell responses to infection.

  7. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-induced changes in Gata2 transcription factor (show GATA2 Proteins) and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C Proteins)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Proteins) signaling via Smad4 protein.

  8. Smad4 knockdown blocks the effects of miR (show MLXIP Proteins)-144-3p inhibitor. MiR (show MLXIP Proteins)-144-3p negatively regulates osteogenic differentiation and proliferation of C3H10T1/2 cells by targeting Smad4.

  9. Studies establish Smad4 as a lung tumor suppressor and suggest that the defective DNA repair phenotype of Smad4-deficient tumors can be exploited by specific therapeutic strategies.

  10. Smad4-dependent TGF-beta (show TGFB1 Proteins) signaling in smooth muscle cells protects against aortic aneurysm formation and dissection.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  2. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Proteins).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Proteins) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 Proteins) and Smad4 have roles in TGF-beta1 (show TGFB1 Proteins)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 Proteins) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Protein Profile

Protein Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4)
  • Smad4 protein (smad4)
  • mothers against decapentaplegic homolog 4 (LOC100342294)
  • SMAD family member 4 (Smad4)
  • SMAD family member 4, gene 1 (smad4.1)
  • AW743858 protein
  • D18Wsu70e protein
  • dpc4 protein
  • jip protein
  • madh4 protein
  • MYHRS protein
  • smad4 protein
  • Xsmad4 protein
  • xsmad4a protein
  • XSmad4alpha protein

Protein level used designations for SMAD Family Member 4 Proteins (SMAD4)

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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