Browse our SMAD4 Proteins (SMAD4)

Full name:
SMAD Family Member 4 Proteins (SMAD4)
On www.antibodies-online.com are 22 SMAD Family Member 4 (SMAD4) Proteins from 13 different suppliers available. Additionally we are shipping SMAD4 Antibodies (187) and SMAD4 Kits (41) and many more products for this protein. A total of 271 SMAD4 products are currently listed.
Synonyms:
AW743858, D18Wsu70e, dpc4, jip, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alpha
list all proteins Gene Name GeneID UniProt
SMAD4 4089 Q13485
SMAD4 17128 P97471
SMAD4 50554 O70437

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SMAD4 Proteins (SMAD4) by Origin

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Top referenced SMAD4 Proteins

  1. Human SMAD4 Protein expressed in Escherichia coli (E. coli) - ABIN666874 : de Caestecker, Hemmati, Larisch-Bloch, Ajmera, Roberts, Lechleider: Characterization of functional domains within Smad4/DPC4. in The Journal of biological chemistry 1997 (PubMed)
    Show all 2 references for 666874

  2. Human SMAD4 Protein expressed in HEK-293 Cells - ABIN2732222 : Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016 (PubMed)

  3. Human SMAD4 Protein expressed in Wheat germ - ABIN1320605 : Iempridee, Das, Xu, Mertz: Transforming growth factor beta-induced reactivation of Epstein-Barr virus involves multiple Smad-binding elements cooperatively activating expression of the latent-lytic switch BZLF1 gene. in Journal of virology 2011 (PubMed)

More Proteins for SMAD4 Interaction Partners

Human SMAD Family Member 4 (SMAD4) interaction partners

  1. miR (show MLXIP Proteins)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (show TGFB1 Proteins)-induced cell cycle arrest. These results suggest that miR (show MLXIP Proteins)-27a may function as an oncogene (show RAB1A Proteins) by regulating SMAD2 (show SMAD2 Proteins) and SMAD4 in lung cancer.

  2. Genetic status of DPC4 contributes to the recurrence patterns in pancreatic ductal adenocarcinoma following pancreatectomy, and patients with an initially expressed DPC4 gene receive a greater benefit from intensive local control for locoregional recurrence

  3. NK cells from a SMAD4-deficient person affected by polyposis were hyper-responsive to TGF-beta

  4. SMAD4 mutation was commonly detected in pancreatic juice samples from patients with Pancreatic Ductal Adenocarcinoma, mutant SMAD4 concentrations could distinguish PDAC from Intraductal Papillary Mucinous neoplasm.

  5. Phosphorylation of SMAD4 is associated with Breast Cancer Metastasis.

  6. Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG (show ENG PLURAL_@42556@), two in BMPR1A (show BMPR1A PLURAL_@42556@), one in PTEN, and one in SMAD4. Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.

  7. Expression levels of Smad4 and miR (show MLXIP Proteins)-34a in colorectal cancer patients had a significant inverse correlation and overexpressing miR (show MLXIP Proteins)-34a inhibited macroautophagy activation by directly targeting Smad4 through the TGF-beta (show TGFB1 Proteins)/Smad4 pathway.

  8. MAD4 (show MXD4 Proteins) has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase (show GSTa2 Proteins) pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.

  9. Upon SMAD4 deletion, we detected high expression levels of FYN (show FYN Proteins) in vessel endothelial cells, suggesting the mechanism of the ovarian tumor cells cross the endothelial barrier and transform to an invasive phenotype

  10. our data suggest that miR (show MLXIP Proteins)-1285-5p functions as a tumor promoter in the development of non-small-cell lung carcinoma by targeting Smad4 and CDH1 (show CDH1 Proteins), indicating a novel therapeutic strategy for non-small-cell lung carcinoma patients.

Mouse (Murine) SMAD Family Member 4 (SMAD4) interaction partners

  1. In SMAD4 deficiency, NK cells unexpectedly acquired an innate lymphoid cell type 1-like gene signature and were unable to control tumor metastasis or viral infection. Mechanistically, SMAD4 restrained non-canonical TGF-beta (show TGFB1 Proteins) signaling mediated by the cytokine receptor (show LEPR Proteins) TGFbetaR1 in NK cells.

  2. The effect of Smad4 was at least partially mediated by the downstream effectors Syk (show SYK Proteins) and ROCK2 (show ROCK2 Proteins) transcription in megakaryocytes

  3. deletion of Smad4 in OBs (show LEP Proteins) differentially modulates HSC (show FUT1 Proteins) fate in a stage-dependent manner

  4. Data suggest that ovarian Bmp4 (show BMP4 Proteins) levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 (show BMP4 Proteins) expression via activation of androgen receptors; Smad4 signaling rather than p38 MAPK (show MAPK14 Proteins) pathway regulates androgen and estrogen formation.

  5. The authors demonstrated that ubiquitin-specific protease (USP) 4 (show USP4 Proteins) strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4.

  6. SMAD4 and STRA8 are essential factors that regulate the female fate of germ cells.

  7. Smad4 is necessary for the activation of the mineralization-related genes, it is dispensable for BMP2 (show BMP2 Proteins) to induce the protein anabolism signature, which instead critically depends on the transcription factor Atf4 (show ATF4 Proteins).

  8. Smad4 may reduce lymphangiogenesis of colon cancer cell by attenuating VEGF-C (show VEGFC Proteins) secretion and act as tumor suppressor by inhibiting migration, invasion and tumorigenicity.

  9. MZF1 (show ZSCAN1 Proteins) has a role in cellular migration of gastric cancer cells via promoting an increase in intracellular SMAD4 levels. This study might provide new evidence for the molecular basis of the tumor suppressive effect of the MZF1 (show ZSCAN1 Proteins)-SMAD4 axis, a new therapeutic target in advanced human gastric cancer.

  10. Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis.

Pig (Porcine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Activated TGF-beta (show TGFB1 Proteins) signaling rescued miR (show MYLIP Proteins)-143-reduced FSHR (show FSHR Proteins) and intracellular signaling molecules, and miR (show MYLIP Proteins)-143-induced porcine granulosa cell apoptosis.

  2. miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.

  3. These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Proteins).

Cow (Bovine) SMAD Family Member 4 (SMAD4) interaction partners

  1. Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Proteins) are SMAD4 dependent.

  2. ALK5 (show TGFBR1 Proteins) and Smad4 have roles in TGF-beta1 (show TGFB1 Proteins)-induced pulmonary endothelial permeability

Xenopus laevis SMAD Family Member 4 (SMAD4) interaction partners

  1. TGF-beta (show TGFB1 Proteins) signaling has a role in nuclear localization of transcription factor Smad4

SMAD4 Protein Profile

Protein Summary

This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Alternative names and synonyms associated with SMAD4

  • SMAD family member 4 (SMAD4)
  • Smad4 protein (smad4)
  • mothers against decapentaplegic homolog 4 (LOC100342294)
  • SMAD family member 4 (Smad4)
  • SMAD family member 4, gene 1 (smad4.1)
  • AW743858 protein
  • D18Wsu70e protein
  • dpc4 protein
  • jip protein
  • madh4 protein
  • MYHRS protein
  • smad4 protein
  • Xsmad4 protein
  • xsmad4a protein
  • XSmad4alpha protein

Protein level used designations for SMAD Family Member 4 Proteins (SMAD4)

Mothers against decapentaplegic-like protein 4 , mothers against decapentaplegic homolog 4 , Smad4 protein , SMAD family member 4 , mothers against decapentaplegic homolog 4-like , MAD homolog 4 , SMAD, mothers against DPP homolog 4 , deleted in pancreatic carcinoma locus 4 , deletion target in pancreatic carcinoma 4 , mothers against decapentaplegic, Drosophila, homolog of, 4 , Smad 4 , deletion target in pancreatic carcinoma 4 homolog , mothers against DPP homolog 4 , MAD (mothers against decapentaplegic Drosophila) homolog 4 , SMAD 4 , MAD, mothers against decapentaplegic homolog 4 , mothers against DPP-like 4 , mothers against decapentaplegic-like 4

GENE ID SPECIES
701803 Macaca mulatta
778905 Ciona intestinalis
100033846 Equus caballus
100409302 Callithrix jacchus
100439171 Pongo abelii
100599586 Nomascus leucogenys
100342294 Oryctolagus cuniculus
4089 Homo sapiens
17128 Mus musculus
50554 Rattus norvegicus
397142 Sus scrofa
540248 Bos taurus
476196 Canis lupus familiaris
100717853 Cavia porcellus
100861019 Capra hircus
443171 Ovis aries
780764 Xenopus laevis
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