SMAD4 Products
(SMAD Family Member 4 (SMAD4))
Categories
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009].
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Featured SMAD4 Categories
SMAD4 Antibodies
High quality antibodies with extensive validation data.
SMAD4 ELISA Kits
Reliable ELISA kits for a wide range of species.
SMAD4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SMAD4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP, CUT&RUN
Validations
- (2)
- (1)
Cat. No.
ABIN6972727
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (8)
Cat. No.
ABIN561723
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (6)
Cat. No.
ABIN7270340
Quantity
100 μL
Datasheet
Datasheet
Recommended SMAD4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970245
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970244
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959514
Quantity
96 tests
Datasheet
Datasheet
Recommended SMAD4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1320605
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125119
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1320607
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SMAD4 products
: "Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways." in: The Journal of biological chemistry, Vol. 293, Issue 9, pp. 3039-3055, (2019) (PubMed).: "Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice." in: Gastroenterology, Vol. 151, Issue 6, pp. 1232-1244.e10, (2016) (PubMed).
: "M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo." in: Translational research : the journal of laboratory and clinical medicine, Vol. 170, pp. 99-111, (2016) (PubMed).
: "The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis." in: Nature communications, Vol. 7, pp. 13436, (2016) (PubMed).
: "Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis." in: Investigative ophthalmology & visual science, Vol. 57, Issue 4, pp. 1612-9, (2016) (PubMed).
: "Effect of Kuijie Granule on the Expression of TGF-β/Smads Signaling Pathway in Patients with Ulcerative Colitis." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 2601830, (2016) (PubMed).
: "Transforming growth factor-?3 regulates cell junction restructuring via MAPK-mediated mRNA destabilization and Smad-dependent protein degradation of junctional adhesion molecule B (JAM-B)." in: Biochimica et biophysica acta, Vol. 1849, Issue 6, pp. 601-11, (2015) (PubMed).
: "Molecular responses of radiation-induced liver damage in rats." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 2592-600, (2015) (PubMed).
: "Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways." in: European journal of nutrition, Vol. 53, Issue 1, pp. 187-99, (2014) (PubMed).
: "Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model." in: Scientific reports, Vol. 4, pp. 5587, (2014) (PubMed).
Synonyms and alternative names related to SMAD4
SMAD family member 4 (SMAD4), Smad4 protein (smad4), SMAD family member 4 (Smad4), SMAD family member 4, gene 1 L homeolog (smad4.1.L), AW743858, D18Wsu70e, DPC4, dpc4, JIP, jip, MADH4, Madh4, madh4, MYHRS, smad4, Xsmad4, xsmad4a, XSmad4alphaProtein level used designations for SMAD4
- Mothers against decapentaplegic-like protein 4
- mothers against decapentaplegic homolog 4
- Smad4 protein
- SMAD family member 4
- mothers against decapentaplegic homolog 4-like
- MAD homolog 4
- SMAD, mothers against DPP homolog 4
- deleted in pancreatic carcinoma locus 4
- deletion target in pancreatic carcinoma 4
- mothers against decapentaplegic, Drosophila, homolog of, 4
- Smad 4
- deletion target in pancreatic carcinoma 4 homolog
- mothers against DPP homolog 4
- MAD (mothers against decapentaplegic Drosophila) homolog 4
- SMAD 4
- MAD, mothers against decapentaplegic homolog 4
- mothers against DPP-like 4
- mothers against decapentaplegic-like 4
Did you look for something else?
- Smad2/3
- SMAD2
- Smad1/9
- SMAD1/5/8/9
- Smad1/5
- SMAD1
- SMAD, Mothers Against DPP Homolog 3
- SLYX
- SLX9
- SLX4IP
- SLX1A/GIYD2
- SLX1 Structure-Specific Endonuclease Subunit Homolog A (S. Cerevisiae)
- SLURP1
- SLUG
- SLUG
- SLU7
- SLTM
- SLPI
- SLN13
- SLN
- SMAD5
- SMAD5-AS1
- SMAD6
- SMAD7
- SMAD9
- SMAGP
- Small Cajal Body-Specific RNA 22
- Small Integral Membrane Protein 12
- Small Nuclear Ribonucleoprotein Polypeptide A
- Small Nuclear RNA Activating Complex, Polypeptide 1, 43kDa
- Small Proline-Rich Protein 2B
- Small Ubiquitin Related Modifier 3
- Small Ubiquitin Related Modifier Protein 1
- SMAP1
- SMAP2
- SMARCA1
- SMARCA2
- SMARCA4
- SMARCA5
- SMARCAD1
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