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Browse our GBA Proteins (GBA)

Full name:
Glucosidase, Beta, Acid Proteins (GBA)
On are 30 Glucosidase, Beta, Acid (GBA) Proteins from 7 different suppliers available. Additionally we are shipping GBA Antibodies (89) and GBA Kits (18) and many more products for this protein. A total of 144 GBA products are currently listed.
BETA-GLUCOSIDASE, betaGC, beta glucosidase 25, GBA1, GC, GCase, GCB, GLUC, PSPTO3318, PSPTO4290, T12J13.8, T12J13_8
list all proteins Gene Name GeneID UniProt
GBA 684536  
GBA 2629 P04062
GBA 14466 P17439

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GBA Proteins (GBA) by Origin

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More Proteins for GBA Interaction Partners

Arabidopsis thaliana Glucosidase, Beta, Acid (GBA) interaction partners

  1. Results describe the characterization of a beta-glucosidase homolog from Arabidopsis thaliana.

Human Glucosidase, Beta, Acid (GBA) interaction partners

  1. GBA enzyme activity in Parkinson disease patients was lower in GBA mutation carriers vs. non-GBA carriers.

  2. Combination of chemo drug with beta-glucosidase 1 inhibitor sensitized hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells to chemotherapy. Our data support b-glucosidase 1 (show MOGS Proteins) as a HCC (show FAM126A Proteins) biomarker due to its prognosis significance

  3. the study supported that GBA mutations were a risk factor for Parkinson's disease in the European population

  4. The clinical phenotype of GBA-associated neurodegenerative disease is more heterogeneous than previously assumed, including phenotypes not usually associated with underlying alpha-synucleinopathies.

  5. there has been a boom in studies investigating the role of glucocerebrosidase in the pathology of Parkinson's disease. This merits a comprehensive review of the current cell biological processes and pathological pictures involving Parkinson's disease associated with GBA mutations

  6. GBA mutations were found to be a common genetic risk factor for Parkinson disease in Eastern Canadian patients.

  7. findings showed that Gaucher disease (GD)-associated GBA mutations were not only associated with the development of Parkinson's disease (PD) but also had a great impact on developing dementia and psychosis in the clinical course of PD

  8. This study discovery that E326K of GBA negatively impacts cognitive performance approximately doubles the proportion of PD patients

  9. This study showed the presence of six LRRK2 (show LRRK2 Proteins) p.G2019S and nine GBA p.N370S mutation carriers in Parkinson disease.

  10. GBA1 mutations interfere with TFEB (show TFEB Proteins)-mediated lysosomal biogenesis, and that the action of GBA in maintaining a functioning pool of lysosomes is exerted in part through TFEB (show TFEB Proteins).

Mouse (Murine) Glucosidase, Beta, Acid (GBA) interaction partners

  1. In LIMP-2-deficient brains a significant reduction in GC activity led to lipid storage, disturbed autophagic/lysosomal function, and alpha-synuclein accumulation.

  2. heterozygosity for a Gaucher disease-associated mutation in glucocerebrosidase interferes with alpha-synuclein degradation and contributes to its accumulation

  3. Data indicate that ABC transporter A family member 12 knockout (Abca12(-/-)) epidermis had 5-fold more beta-glucocerebrosidase (GCase) protein, and a 5-fold increase in GCase activity.

  4. These results demonstrate, for the first time, a novel function of GBA1 as a beta (show SUCLA2 Proteins)-ChlGlc-synthesizing enzyme.

  5. Substrate compositional variation with tissue/region and Gba1 mutations in mouse models--implications for Gaucher disease.

  6. GBA1 and GBA2 (show GBA2 Proteins) activities had characteristic differences between the studied fibroblast, liver and brain samples.

  7. results not only point to a fundamental role for GBA in immune regulation but also suggest that GBA mutations in GD may cause widespread immune dysregulation through the accumulation of substrates

  8. This study suggested that several leads connecting GBA1 mutations with alpha-synuclein misprocessing have emerged as potential targets for the treatment of GBA1-related synucleinopathies.

  9. IFG (show IFNG Proteins) stabilizes GCase in tissues and serum and can reduce visceral substrates in vivo.

  10. Mutations in GBA1 can cause Parkinson disease-like alpha-synuclein pathology; rescuing brain glucocerebrosidase activity might represent a therapeutic strategy for GBA1-associated synucleinopathies.

Pig (Porcine) Glucosidase, Beta, Acid (GBA) interaction partners

  1. genetic analysis and mapping of the porcine glucocerebrosidase (GBA) gene

GBA Protein Profile

Protein Summary

This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with GBA

  • glucosidase, beta, acid (Gba)
  • glucosidase, beta, acid (GBA)
  • beta glucosidase 25 (BGLU25)
  • beta-glucosidase (PSPTO_3318)
  • beta-glucosidase (bglX)
  • beta-glucosidase (bglH-2)
  • beta-glucosidase (bglX-1)
  • beta-glucosidase (bglX-2)
  • beta-glucosidase (bglA.2)
  • bglX-2 (bglX-2)
  • Beta-glucosidase (bglA4)
  • betaGC protein
  • beta glucosidase 25 protein
  • GBA1 protein
  • GC protein
  • GCase protein
  • GCB protein
  • GLUC protein
  • PSPTO3318 protein
  • PSPTO4290 protein
  • T12J13.8 protein
  • T12J13_8 protein

Protein level used designations for Glucosidase, Beta, Acid Proteins (GBA)

glucocerebrosidase , glucosidase, beta, acid , glucosylceramidase-like , beta-glucosidase , Beta-glucosidase , D-glucosyl-N-acylsphingosine glucohydrolase , acid beta-glucosidase , alglucerase , beta-glucocerebrosidase , glucosylceramidase , imiglucerase , lysosomal glucocerebrosidase , acid beta glucosidase , glucosidase, beta; acid (includes glucosylceramidase) , glucosidase, beta; acid

684536 Rattus norvegicus
100399524 Callithrix jacchus
821201 Arabidopsis thaliana
1184976 Pseudomonas syringae pv. tomato str. DC3000
1185971 Pseudomonas syringae pv. tomato str. DC3000
2797087 Listeria monocytogenes serotype 4b str. F2365
2799486 Listeria monocytogenes serotype 4b str. F2365
2799824 Listeria monocytogenes serotype 4b str. F2365
3573796 Streptococcus pyogenes MGAS6180
4464997 Listeria welshimeri serovar 6b str. SLCC5334
5812753 Sorangium cellulosum So ce56
8955533 Sphingobium japonicum UT26S
2629 Homo sapiens
14466 Mus musculus
537087 Bos taurus
449572 Sus scrofa
100174563 Pongo abelii
449571 Pan troglodytes
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