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anti-Rat (Rattus) CX3CR1 Antibodies:
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Mouse (Murine) Polyclonal CX3CR1 Primary Antibody for FACS - ABIN4897825
Wattananit, Tornero, Graubardt, Memanishvili, Monni, Tatarishvili, Miskinyte, Ge, Ahlenius, Lindvall, Schwartz, Kokaia: Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
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Mouse (Murine) Polyclonal CX3CR1 Primary Antibody for FACS - ABIN4897824
Andriessen, Wilson, Mawambo, Dejda, Miloudi, Sennlaub, Sapieha: Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. in EMBO molecular medicine 2016
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Human Polyclonal CX3CR1 Primary Antibody for ELISA, FACS - ABIN4301023
Aoyama, Inokuchi, Brenner, Seki: CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. in Hepatology (Baltimore, Md.) 2010
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Human Polyclonal CX3CR1 Primary Antibody for CyTOF, FACS - ABIN4900502
Fan, Xiong, Zhang, Yan, Jian, Xu, Zhao: MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. in Journal of the American Heart Association 2016
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Human Polyclonal CX3CR1 Primary Antibody for FACS, IHC - ABIN110594
Held-Feindt, Hattermann, Mueerkoester, Wedderkopp, Knerlich-Lukoschus, Ungefroren, Mehdorn, Mentlein: CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). in Experimental cell research 2010
Human Polyclonal CX3CR1 Primary Antibody for FACS, WB - ABIN2473127
Imai, Hieshima, Haskell, Baba, Nagira, Nishimura, Kakizaki, Takagi, Nomiyama, Schall, Yoshie: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. in Cell 1997
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Human Monoclonal CX3CR1 Primary Antibody for FACS - ABIN4896933
Falk, Singh, Faber, Nissen, Hviid, Sørensen: CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. in PLoS ONE 2014
Mouse (Murine) Polyclonal CX3CR1 Primary Antibody for FACS - ABIN4897820
Arieta Kuksin, Gonzalez-Perez, Minter: CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. in Blood 2015
Mouse (Murine) Polyclonal CX3CR1 Primary Antibody for FACS - ABIN4897823
Nie, Li, Hu, Jin, Yu, Cai, Shao, Shen, Yi, Xiao, Shen, He: Atorvastatin improves plaque stability in ApoE-knockout mice by regulating chemokines and chemokine receptors. in PLoS ONE 2014
CX3CR1 genetic variants were not associated with risk of atherosclerotic coronary heart disease and glucometabolic traits in European ancestry cohort. In a South Asian cohort, identified CX3CR1 SNP associated with myocardial infarction and type II diabetes mellitus.
FKN and CX3CR1 expression was significantly increased in pancreatic ductal adenocarcinoma (PDAC) tissues, especially in the metastatic samples, and was highly-correlated with severity of PDAC. Ectopic expression of FKN promoted the proliferation and migration of PDAC, while knockdown of CX3CR1 reversed the function of FKN.
CX3CL1 (show CX3CL1 Antibodies) is upregulated in both human and murine tumors following VEGF (show VEGFA Antibodies) signaling blockade, resulting in recruitment of CX3CR1+Ly6Clo monocytes into the tumor
The fractalkine (show CX3CL1 Antibodies) functions on the activation of the AKT (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) signalling cascade and regulation of the antiapoptosis process in pancreatic cancer cells.
High expression of CX3CR1 correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine (show CX3CL1 Antibodies) axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.
V249I genotype of the fractalkine receptor showed a protector role in patients with type 2 diabetes. The T280M genotype is associated with increased carotid intima-media thickness in Mexican individuals with or without type 2 diabetes
CX3CR1 genetic variation sows a possible association with hypertension, diabetes mellitus and atherosclerosis comorbidities in patients treated with hemodialysis.
this study shows that the expression of CX3CR1 on tonsillar CD8-positive cells is higher in IgA nephropathy patients
Low CCRL1 expression is associated with hepatocellular carcinoma.
Recent works show that, in allergic diseases, there is an increased expression of fractalkine/CX3CL1 (show CX3CL1 Antibodies) and its unique receptor CX3CR1 and that this chemokine (show CCL1 Antibodies) does not act as chemoattractant. In allergic asthma, CX3CR1 expression regulates Th2 and Th1 (show TH1L Antibodies) cell survival in the inflammatory lung, while, in atopic dermatitis, it regulate Th2 and Th1 (show TH1L Antibodies) cell retention into the inflammatory site. [review]
These results highlight the importance of fractalkine (show CX3CL1 Antibodies)-CX3CR1 interaction in recruitment of macrophages into the brown adipose tissue of obese mice.
Results indicate that deletion of CX3CR1 from microglia under resting conditions modifies brain areas with elevated cellular turnover independent of CX3CL1 (show CX3CL1 Antibodies).
The CX3CL1 (show CX3CL1 Antibodies)/CX3CR1 system is essential for restricting coxsackievirus B3-induced myocarditis.
Results establish an essential role for the receptor CX3CR1 in gut (show GUSB Antibodies) macrophages in resolving inflammation in the intestine, where it helps protects against colitis-associated cancer by regulating HMOX-1 (show HMOX1 Antibodies) expression.
CX3CR1 significantly contributes to changes in microglia morphology in the proximal peri (show POSTN Antibodies)-infarct area following transient occlusion of the middle cerebral artery. Morphological alterations suggest a shift in microglia functionality integrated in the inflammatory response after stroke. Results show that CX3CR1 deficiency has no beneficial effect on lesion size neither it affects early functional outcome after stroke.
we demonstrated that CX3CR1(Lo)CCR2 (show CCR2 Antibodies)(Hi) monocytes were recruited to the GBM, where they transitioned to CX3CR1(Hi)CCR2 (show CCR2 Antibodies)(Lo) macrophages and CX3CR1(Hi)CCR2 (show CCR2 Antibodies)(-) microglia-like cells. Infiltrating macrophages/monocytes constituted approximately 85% of the total TAM (show CCNA1 Antibodies) population, with resident microglia accounting for the approximately 15% remaining.
CXCR4 (show CXCR4 Antibodies), CCR2 (show CCR2 Antibodies), and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung differentially.
Published data show that genetic deletion of CX3CR1, a microglia-specific chemokine receptor, promotes recovery after traumatic spinal cord injury in mice, a benefit achieved in part by reducing macrophage-mediated injury at the lesion epicenter. Data in the current manuscript indicate that CX3CR1 deletion changes microglia and macrophage function, creating a tissue microenvironment that enhances endogenous repair.
this reduction in lesion formation was associated with reduced numbers of lesional SMCs but not macrophages within the transplanted Cx3cr-/- Apoe (show APOE Antibodies)-/- aortic segment. No differences in frequencies of proliferating and apoptotic cells could be observed. These results indicate that CX3CR1 on resident vessel wall cells plays a key role in atherosclerotic plaque formation in transplanted aortic grafts
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
CX3C chemokine receptor 1
, chemokine (C-C motif) receptor-like 1
, CX3C chemokine receptor 1-like
, c-C chemokine receptor type 11-like
, chemokine (C-X3-C motif) receptor 1
, C-X-C chemokine receptor type 1
, chemokine receptor CXCR1
, C-X3-C CKR-1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, Fractalkine receptor
, chemokine receptor 1