Browse our EDNRB Proteins (EDNRB)

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Endothelin Receptor Type B Proteins (EDNRB)
On are 9 Endothelin Receptor Type B (EDNRB) Proteins from 4 different suppliers available. Additionally we are shipping EDNRB Antibodies (112) and EDNRB Kits (14) and many more products for this protein. A total of 141 EDNRB products are currently listed.
ABCDS, Ednra, ednrb, ET-B, ET-BR, ETb, ETBR, ETR-b, ETRB, HSCR, HSCR2, Sox10m1, WS4A
list all proteins Gene Name GeneID UniProt
EDNRB 1910 P24530
Rat EDNRB EDNRB 50672 P21451
EDNRB 13618 P48302

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EDNRB Proteins (EDNRB) by Origin

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More Proteins for EDNRB Interaction Partners

Human Endothelin Receptor Type B (EDNRB) interaction partners

  1. An IL2 (show IL2 Proteins)-targeted antibody failed to detect transfected ETB in HEK293 cultures. In contrast, the NT-targeted antibody accurately detected transfected ETB in HEK293 cultures by labeling a 37-kDa band.

  2. In control arteries, ETAR (show EDNRA Proteins) was expressed by vascular smooth muscle cells in the media whereas ETBR was hardly detected. In giant cell arteritis, both ETAR (show EDNRA Proteins) and ETBR receptors were expressed by alphaSMA (show ACTA2 Proteins)-positive cells at the intima-media border. Endothelial cells and inflammatory cells also expressed both ET receptors.

  3. This study concluded that ETB receptors mediate vasodilation in young women, but this effect is lost after menopause.

  4. Our results suggest that EDNRB rs5351 single nucleotide polymorphism is a strong independent predictor of essential hypertension in men of Tatar ethnic origin.

  5. No rare EDNRB variants were identified among 57 patients with Hirschsprung disease.

  6. Taking into account that the cohort we screened was deprived of patients previously found mutated in MITF (show MITF Proteins) (about 15%) and SOX10 (show SOX10 Proteins) (another 15%), our 8% mutation rate indicates that EDNRB heterozygous mutations represent about 5%-6% of all WS2 (show MITF Proteins), making it the third gene of this subtype.

  7. Data suggest that TNFalpha (tumor necrosis factor-alpha (show TNF Proteins)) induces proliferation of airway smooth muscle cells via ET1 (endothelin-1 (show EDN1 Proteins)), GM-CSF (granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins)), and IL6 (interleukin 6 (show IL6 Proteins)) signaling; ET1 (show EDN1 Proteins) induces cell proliferation via ETAR (endothelin receptor type A (show EDNRA Proteins)); ETBR (endothelin receptor type B) is up-regulated by TNFalpha (show TNF Proteins) and appears to mediate ET1 (show EDN1 Proteins) effects on cell proliferation.

  8. genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3 (show EDN3 Proteins)) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer.

  9. The high level of ETBR expression observed in CMS (show Cd2ap Proteins) patients compared to healthy controls suggests that the cerebral hypoxia diastolic reaction is possible due to ETBR, rather than ET-1 (show EDN1 Proteins) itself.

  10. crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the endogenous agonist endothelin-1 (show EDN1 Proteins)

Mouse (Murine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. ETB receptors in vascular smooth muscle make a small but significant contribution to ETB-dependent regulation of BP. These ETB receptors have no effect on vascular contraction or neointimal remodeling.

  2. Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 (show EDN1 Proteins) via upregulation of the ETB receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.

  3. Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss.

  4. we show that ET-1 (show EDN1 Proteins) acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination.

  5. EDNRB plays a key role in hypoxia tolerance

  6. The cardiac expression of prepro-endothelin-1 (show EDN1 Proteins) mRNA, endothelin-converting enzyme-1 (show ECEL1 Proteins) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight

  7. results indicate that the Notch1 (show NOTCH1 Proteins)-STAT3 (show STAT3 Proteins)-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury

  8. Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease.

  9. pathophysiological events in the brain in sepsis mediated by ET-1 (show EDN1 Proteins)/ETB receptor axis, were evaluated.

  10. PROD (show TAF8 Proteins)-rol/rol mice with classic piebald mutation have two mutant genes, Ednrb and Cacna1a (show CACNA1A Proteins).

Pig (Porcine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.

  2. ET(A (show EDNRA Proteins))/ET(B) blockade decreased pulmonary vascular resistance but only during exercise.

  3. endothelial endothelin ET(B) receptors induce NO and EDHF mediated vasodilatation in porcine coronary arteries; in organ culture, endothelial endothelin ET(B) receptors are down-regulated

  4. PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries

  5. extracellular ET-1 (show EDN1 Proteins) regulates the abundance of ET-1 (show EDN1 Proteins) mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK (show MAPK1 Proteins) and p38 MAPK (show MAPK14 Proteins) pathways

Cow (Bovine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  2. Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

Horse (Equine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR (show EDNRA Proteins) antagonists might be beneficial for treatment of laminitis in horses.

  2. both ETA and ETB receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins

Rabbit Endothelin Receptor Type B (EDNRB) interaction partners

  1. Stimulation of ETA and ETB receptors activates native protein kinase C-dependent transient receptor potential channel (TRPC)1 through phospholipid pathways involving phosphoinositol-3,4,5-trisphosphate (PIP)3 and PIP2 in coronary artery myocytes.

  2. ET(B) receptor stimulation relaxes the carbachol precontracted iris sphincter muscle, an effect that is mediated by the ET(B2) receptor subtype, through NO and the release of prostaglandins.

EDNRB Protein Profile

Protein Summary

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with EDNRB

  • endothelin receptor type B (EDNRB)
  • endothelin receptor type B (ednrb)
  • endothelin receptor B subtype 2 (ednrb2)
  • endothelin receptor type B (Ednrb)
  • ABCDS protein
  • Ednra protein
  • ednrb protein
  • ET-B protein
  • ET-BR protein
  • ETb protein
  • ETBR protein
  • ETR-b protein
  • ETRB protein
  • HSCR protein
  • HSCR2 protein
  • Sox10m1 protein
  • WS4A protein

Protein level used designations for EDNRB

endothelin receptor type B , endothelin B receptor , endothelin receptor B , endothelin-B receptor , endothelin receptor non-selective type , ET-B , ET-BR , piebald , endothelin receptor subtype B , endothelin ETB receptor

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1910 Homo sapiens
50672 Rattus norvegicus
13618 Mus musculus
403862 Canis lupus familiaris
414911 Sus scrofa
281750 Bos taurus
100033875 Equus caballus
100009477 Oryctolagus cuniculus
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