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genome-wide association studies in population of women in China: Data suggest that EDN3 (endothelin 3 (show EDN3 Proteins)) and EDNRB (endothelin receptor type B) play important roles in the molecular mechanisms underlying cervical cancer.
The high level of ETBR expression observed in CMS (show Cd2ap Proteins) patients compared to healthy controls suggests that the cerebral hypoxia diastolic reaction is possible due to ETBR, rather than ET-1 (show EDN1 Proteins) itself.
crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the endogenous agonist endothelin-1 (show EDN1 Proteins)
Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss.
This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies
Serum EDNRB hypermethylation is a highly specific but not sensitive serum biomarker for HNSCC
High Endothelin B receptor expression is associated with malignant gliomas.
EDNRB plays a key role in hypoxia tolerance
The increased gene expression of MITF (show MITF Proteins) and EDNRB in UVB-exposed NHMs.
culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB
we show that ET-1 (show EDN1 Proteins) acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination.
The cardiac expression of prepro-endothelin-1 (show EDN1 Proteins) mRNA, endothelin-converting enzyme-1 (show ECEL1 Proteins) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight
results indicate that the Notch1 (show NOTCH1 Proteins)-STAT3 (show STAT3 Proteins)-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury
Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease.
pathophysiological events in the brain in sepsis mediated by ET-1 (show EDN1 Proteins)/ETB receptor axis, were evaluated.
PROD (show TAF8 Proteins)-rol/rol mice with classic piebald mutation have two mutant genes, Ednrb and Cacna1a (show CACNA1A Proteins).
Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3 (show EDN3 Proteins)-null mouse models of Hirschsprung-associated enterocolitis.
ednrb expression in the heart was restricted to the endocardium and coronary endothelium
PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.
ET(A (show EDNRA Proteins))/ET(B) blockade decreased pulmonary vascular resistance but only during exercise.
endothelial endothelin ET(B) receptors induce NO and EDHF mediated vasodilatation in porcine coronary arteries; in organ culture, endothelial endothelin ET(B) receptors are down-regulated
PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries
extracellular ET-1 (show EDN1 Proteins) regulates the abundance of ET-1 (show EDN1 Proteins) mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK (show MAPK1 Proteins) and p38 MAPK (show MAPK14 Proteins) pathways
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR (show EDNRA Proteins) antagonists might be beneficial for treatment of laminitis in horses.
both ETA and ETB receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins
Stimulation of ETA and ETB receptors activates native protein kinase C-dependent transient receptor potential channel (TRPC)1 through phospholipid pathways involving phosphoinositol-3,4,5-trisphosphate (PIP)3 and PIP2 in coronary artery myocytes.
ET(B) receptor stimulation relaxes the carbachol precontracted iris sphincter muscle, an effect that is mediated by the ET(B2) receptor subtype, through NO and the release of prostaglandins.
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endothelin receptor type B
, endothelin B receptor
, endothelin receptor B
, endothelin-B receptor
, endothelin receptor non-selective type
, endothelin receptor subtype B
, endothelin ETB receptor