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anti-Human Fibronectin Antibodies:
anti-Mouse (Murine) Fibronectin Antibodies:
anti-Rat (Rattus) Fibronectin Antibodies:
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Chicken Monoclonal Fibronectin Primary Antibody for ICC, IHC (fro) - ABIN3043242
Zhang, Chen, Qi, Wang, Xiao, Zhu: Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion. in Journal of cardiovascular pharmacology 2010
Show all 15 Pubmed References
Human Monoclonal Fibronectin Primary Antibody for FACS, ELISA - ABIN969520
Ryschich, Khamidjanov, Kerkadze, Büchler, Zöller, Schmidt: Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. in Pancreas 2009
Show all 2 Pubmed References
Human Monoclonal Fibronectin Primary Antibody for FACS, IHC - ABIN969149
Huang, Zhang, Kim, Ge, Annis, Mosher, Greenspan: Fibronectin binds and enhances the activity of bone morphogenetic protein 1. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Monoclonal Fibronectin Primary Antibody for FACS - ABIN4898545
Purushothaman, Bandari, Liu, Mobley, Brown, Sanderson: Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. in The Journal of biological chemistry 2016
Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage
Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
reduction of fn1 function enables rescue of cardiac fusion in hand2 (show HAND2 Antibodies) mutants
Fibronectin regulates epithelial organization during myocardial migration in zebrafish.
Thyroid hormone (show PTH Antibodies) T3 induces fibronectin and HIF-1alpha (show HIF1A Antibodies) synthesis via PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway.
Fibronectin and Hepatocyte Growth Factor (show HGF Antibodies) were shown to be produced by lung fibroblasts and, furthermore, to enhance malignant pleural mesothelioma cell migration and invasion
Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1 (show WWC1 Antibodies)), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3 (show CELSR3 Antibodies)), NIPBL (show NIPBL Antibodies) (Nipped (show RPL38 Antibodies)-B-like), and FN1 (fibronectin 1).
fibrillar fibronectin on this polymer, but not a globular conformation obtained on control polymers, promotes synergistic presentation of integrin-binding sites and bound bone morphogenetic protein 2 (BMP-2 (show BMP2 Antibodies)), which enhances mesenchymal stem cell osteogenesis in vitro and drives full regeneration of a nonhealing bone defect in vivo at low GF concentrations.
Fn plays a critical role in inflammasome-activated cells by amplifying caspase-1 (show CASP1 Antibodies) activation and inducing inflammatory cell death.
If the expression of Capon (show NOS1AP Antibodies) is decreased, myeloma cells are adhered to fibronectin or bone marrow stromal cells (bone marrow mesenchymal stem cells). In addition, the sensitivity of the cell line to chemotherapeutic agents was reduced after silencing Capon (show NOS1AP Antibodies) in the myeloma cell line which was adhered to bone marrow mesenchymal stem cells.
C-terminal truncation of transglutaminase 2 (TG2 (show TGM2 Antibodies)) reduces binding to the small intestinal extracellular matrix (ECM (show MMRN1 Antibodies)) despite retained fibronectin (FN)-binding capacity.
analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation
In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Antibodies) Ang-1 (show ANGPT1 Antibodies), but not the receptor binding domain of Ang-2 (show ANGPT2 Antibodies), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Antibodies) signaling in the presence of both Ang-1 (show ANGPT1 Antibodies) and fibronectin
Results directly implicate the heparin-binding sequence of the first type III repeat of fibrillar fibronectin (FNIII1) in realignment of stress fibers in HUVECs and, importantly, show that the matricryptic heparin-binding RWRPK sequence located in FNIII1 is required for the response.
fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities
The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK (show MAPK14 Antibodies) pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.
scleraxis (show SCX Antibodies) was required for TGFbeta (show TGFB1 Antibodies)-induced fibronectin expression: TGFbeta (show TGFB1 Antibodies) lost its ability to induce fibronectin expression following scleraxis (show SCX Antibodies) knockdown.
The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 (show LGALS3 Antibodies) as opposed to fibronectin.
Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
These results suggest that the Rac1 regulation of the FN arrangement is involved in retinoic acid-induced cleft palate.
Fibrillar cellular fibronectin supports platelet adhesion, activation, aggregation and procoagulant activity via the interplay of a series of receptors i.e. integrins alpha5beta1 and alphaIIbbeta3, the GPIb-V-IX complex, GPVI (show GP6 Antibodies) and Toll-like receptor 4 (show TLR4 Antibodies).
Fn1 synthesized by the neural crest mediated morphogenesis of the aortic arch artery and differentiation of neural crest cells into vascular smooth muscle cells by regulating Notch (show NOTCH1 Antibodies) signaling.
A novel mechanism of transcriptional regulation of fibronectin through CREB (show CREB1 Antibodies).
plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.
Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta (show TGFB1 Antibodies) when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.
Putative function of fibronectin and its receptor (integrin alpha(5 (show ITGA5 Antibodies))beta(1)) in male and female gametes during bovine fertilization in vitro.
These results highlight a crucial role for caveolin-1 (show CAV1 Antibodies) in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.
P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn
The expression of extracellular matrix molecules fibronectin and osteopontin (show SPP1 Antibodies) in vitreous and retina samples in autoimmune uveitis was investigated.
The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.
The relationship between hyaluronan synthesis and levels of versican (show Vcan Antibodies), fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
fibronectin has a cryptic binding site for tenascin (show TNC Antibodies)
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
, gene C
, cold-insoluble globulin
, migration-stimulating factor
, cumulus cell-specific fibronectin 1 transcript
, embryo-specific fibronectin 1 transcript
, fibronectin ED-A- region
, fibronectin variable region