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Human ICAM-1 Protein expressed in Human Cells - ABIN2002637
Bhalla, Chugh, Mehrotra, Rathore, Tousif, Prakash Dwivedi, Prakash, Kumar Samuchiwal, Kumar, Kumar Singh, Ghanwat, Kumar, Das, Mohmmed, Malhotra, Ranganathan: Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. in Nature communications 2015
Following transepithelial migration, neutrophils adhesion to ICAM-1 resulted in activation of Akt (show AKT1 Proteins) and beta-catenin (show CTNNB1 Proteins) signaling, increased epithelial-cell proliferation, and wound healing.
P-Selectin and ICAM-1 have roles in mediating THP-1 monocyte adhesion
Dissection of the molecular mechanism revealed that the p38 (show CRK Proteins)-Notch1 (show NOTCH1 Proteins) axis was the main downstream signaling pathway in CD54-mediated regulation of cancer stem cells in prostate cancers.
We show that knockdown of the expression of mcircRasGEF1B reduces LPS (show IRF6 Proteins)-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs.
Buerger's patients had a significant increase in circulating HMGB-1 (show HMGB1 Proteins), MMP-9 (show MMP9 Proteins) and ICAM-1.
SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 (show HMGA1 Proteins) gene were not associated with the susceptibility of DR in the Chinese T2DM cohort.
his study shows that two adhesion molecules, shed as soluble forms, are elevated during the acute phase of leptospirosis: E-selectin (show SELE Proteins) and s-ICAM1. These molecules may interfere with the process of immune cell recruitment to clear Leptospira at tissue levels.
data suggest that CD2AP (show Cd2ap Proteins) acts as a negative regulator of ICAM-1 clustering, which limits the formation of ICAM-1 adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.
findings show that endothelial MAPKs ERK (show EPHB2 Proteins), p38 (show CRK Proteins), and JNK (show MAPK8 Proteins) mediate diapedesis-related and diapedesis-unrelated functions of ICAM-1 in cerebral and dermal microvascular endothelial cells
Addition of CYM5442 in culture media reduced the production of ICAM1 via a dosage- and time-dependent manner
Blocking CD54 inhibited NK cell-mediated cytotoxicity of the GM-CSF (show CSF2 Proteins)-stimulated Flt3 ligand (show FLT3LG Proteins) conventional dendritic cells. NK cell-mediated lysis of GM-CSF (show CSF2 Proteins)-stimulated cDCs was, in part, a result of increased expression of CD54.
These results indicate that, whereas T cells use ICAM-1 and -2 for temporary pulmonary entrapment, neutrophils get sequestered and extravasate into inflamed lungs independent of ICAMs.
This study indicates that the ANG II (show AGT Proteins) effects are, in part, mediated or triggered by Gal-3 (show LGALS3 Proteins) together with the related intercellular signaling (ICAM-1 and IL-6 (show IL6 Proteins)), leading to cardiac inflammation and fibrosis.
Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1) and fibronectin (show FN1 Proteins) plus activation of Nrf2 (show NFE2L2 Proteins)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.
ICAM1 regulates pathological cardiac remodeling by mediating proinflammatory leukocyte infiltration in the left ventricle and cardiac fibrosis and dysfunction.
Its antiatherogenic impact might be associated with a suppressed adhesion to the endothelium due to down-regulation of endothelial ICAM-1 expression.
Luteolin may inhibit tumor angiogenesis and tumor cell proliferation by down-regulation of LFA- 3 and PCNA (show PCNA Proteins) and up-regulation of ICAM-1 in tumor tissue of tumor-bearing mice, thereby achieving its anti-tumor effect.
our results further highlight the pleiotropic role of ICAM-1 in T-cell-dependent immune responses, with a major role in Treg cell development and suppressive function.
the present results shed light on regulation of expression and function of ICAM-1 on neutrophils and identify it as an additional regulator of neutrophil effector responses in host defense.
ADMA has potent adverse effects on cell proliferation, intracellular ROS (show ROS1 Proteins) generation, cell permeability, levels of ICAM-1, and the tight-junction protein occludin (show OCLN Proteins)
Neutrophil lung infiltrations in porcine reproductive and respiratory syndrome virus infection infected animals is both ICAM-1 dependent and independent.
Chitosan oligosaccharides downregulate the expression of E-selectin (show SELE Proteins) and ICAM-1 by inhibiting the phosphorylation of Mitogen-Activated Protein Kinases and the activation of NF-kappaB (show NFKB1 Proteins) in lipopolysaccharides treated porcine iliac artery endothelial cells.
Data show that all five molecules, BNP, ICAM-1, TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6 (show IL6 Proteins), quickly and reliably signaled adverse interactions.
Altered shear stress stimulates upregulation of endothelial VCAM-1 (show VCAM1 Proteins) and ICAM-1 in a BMP-4 (show BMP4 Proteins)- and TGF-beta1 (show TGFB1 Proteins)-dependent pathway.
ICAM1 and IL10 (show IL10 Proteins) were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 (show JUN Proteins) may be responsible for this upregulation.
Hepatocellular glycogen (show GYS1 Proteins) decreases the expression of ICAM-1 mRNA of hepatic stellate cells.
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor.
intercellular adhesion molecule 1
, intercellular adhesion molecule 1-like
, cell surface glycoprotein P3.58
, intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
, major group rhinovirus receptor
, leukocyte adhesion molecule