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Study reveals that specification of all macrophages requires irf8 during an early period of zebrafish hematopoiesis but not during the adult-phase. Also, Irf8 seems to have essential roles in host defense as well.
Irf8 is a critical determinant for neutrophil versus macrophage fate choice during zebrafish primitive myelopoiesis.
down-regulation of IRF8 in the wound leads to impaired wound healing possibly through the regulation of macrophage function and apoptosis in skin wound.
IRF8 may contribute to the genetic susceptibility of Behcet's disease by regulating IRF8 expression and cytokine production.
IRF5 (show IRF5 ELISA Kits) and IRF8, two transcription factors with opposing functions, control TLR9 (show TLR9 ELISA Kits) signaling in human plasmacytoid dendritic cells.
cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224, which can counteract the repressive activity of WT1 (show WT1 ELISA Kits) on the IRF8-promoter
Expression of WT1and IRF8 showed a moderate inverse correlation in acute myeloid leukemia (show BCL11A ELISA Kits) patients. WT1 (show WT1 ELISA Kits) can be used as an minimal residual disease marker, especially in patients without recurrent genetic abnormalities.
Results show that IRF8 is a possible genetic variant associated with the development of HT and production of thyroid antibody
The IRF8 gene variant influenced the interaction between IRF8 and NF-kappaB (show NFKB1 ELISA Kits) and thus susceptibility to systemic sclerosis.
This article provides an overview of recent advances in our understanding of the role of IRF8 in myelopoiesis and related diseases. [review]
This study demonstrated that the Polymorphism, Single Nucleotide of IRF8 is associated with multiple sclerosis in woman in Russia.
gene variants in IRF5 (show IRF5 ELISA Kits), IRF8 and GPC5 (show GPC5 ELISA Kits) were not associated with risk of relapse or disease progression in multiple sclerosis
IRF8 might play a role in restraining excess lymphocyte proliferation.
IRF8 controls Th1 immune response in Treg cells independent of T-bet.
The authors further identified a distinct molecular signature of F4/80(hi) and CD11b (show ITGAM ELISA Kits)(hi) macrophages and found that Irf8 was vital for macrophage maturation.
this study shows that myeloid-specific SIRT1 (show SIRT1 ELISA Kits) restrains pro-inflammatory processes by deacetylating IRF8
IRF8 was a target of miR (show MLXIP ELISA Kits)-451a in vitro and in vivo. The data indicate the function and a target of miR (show MLXIP ELISA Kits)-451a in SLE
the mechanism for the observed differential induction of the mouse Ifit1 (show IFIT1 ELISA Kits), Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation.
direct the expression of a set of genes, the IRF8/IRF1 (show IRF1 ELISA Kits) regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
we identified IRF8 target genes in gastric epithelial cells, providing a detailed understanding of how IRF8 functions in gastric mucosal innate immunity
results suggest that impaired Icsbp expression enhances leukemogenesis by deregulating processes that normally limit granulocyte expansion during the innate immune response.
variation in IRF4 (show IRF4 ELISA Kits) or IRF8 levels resulting from genetic polymorphisms or environmental cues will govern tissue dendritic cells numbers and regulate the magnitude of their functional responses.
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
, interferon regulatory factor 8
, interferon regulatory factor 8-like
, interferon consensus sequence binding protein 1
, interferon consensus sequence-binding protein
, transcription factor ICSBP
, interferon consensus sequence binding protein