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Browse our Metadherin Proteins (MTDH)

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Metadherin Proteins (MTDH)
On are 8 Metadherin (MTDH) Proteins from 4 different suppliers available. Additionally we are shipping Metadherin Antibodies (98) and Metadherin Kits (9) and many more products for this protein. A total of 120 Metadherin products are currently listed.
3D3, 3D3/Lyric, 2610103J23Rik, AEG-1, AEG1, AV353288, D8Bwg1112e, LYRIC, LYRIC/3D3, MGC75963
list all proteins Gene Name GeneID UniProt
MTDH 67154 Q80WJ7
Rat MTDH MTDH 170910 Q9Z1W6
MTDH 92140 Q86UE4

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Metadherin Proteins (MTDH) by Origin

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Top referenced Metadherin Proteins

  1. Human MTDH Protein expressed in Human - ABIN2712327 : Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015 (PubMed)

More Proteins for Metadherin Interaction Partners

Mouse (Murine) Metadherin (MTDH) interaction partners

  1. AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.

  2. When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.

  3. MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis

  4. Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.

  5. RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed

  6. Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.

  7. IL-1beta (show IL1B Proteins)- or TNF-alpha (show TNF Proteins)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.

  8. MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Proteins).

  9. oncogene (show RAB1A Proteins) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF Proteins) superfamily member TRAIL (Tumor Necrosis Factor (show TNF Proteins)-related Apoptosis-inducing Ligand) in breast cancer

  10. The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.

Human Metadherin (MTDH) interaction partners

  1. our findings suggest that AEG-1 promotes mesenchymal transition in glioblastoma through the regulation of the Rho signaling pathway, resulting in tumor invasion, a primary characteristic of malignant brain tumors

  2. these findings suggested that miR (show MLXIP Proteins)-124 was able to suppress cell proliferation, invasion and migration, as well as the EMT (show ITK Proteins) process in cervical carcinomas through directly targeting AEG-1. miR (show MLXIP Proteins)-124 and AEG-1 may be potential

  3. Our results suggest that underexpression of miR (show MLXIP Proteins)-30a-5p might function as a tumor suppressing miRNA by directly targeting MTDH in HCC (show FAM126A Proteins) and is therefore a potential candidate biomarker for HCC (show FAM126A Proteins) targeting therapy.

  4. MiR (show MLXIP Proteins)-136 plays a key role in temozolomide (TMZ) resistance by targeting AEG-1 in glioma cell line, suggesting that miR (show MLXIP Proteins)-136 can be used to predict a patient's response to TMZ therapy as well as serve as a novel potential maker for glioma therapy.

  5. Data indicate metadherin (MTDH) as a direct target gene of microRNA miR (show MLXIP Proteins)-630.

  6. AEG-1 overexpression is closely associated with epithelial-mesenchymal transition and promote metastasis in tongue squamous cell carcinoma.

  7. MiR (show MLXIP Proteins)-30a-5p may play an essential role in the cell growth and apoptosis of hepatocellular carcinoma cells, partially via targeting AEG-1.

  8. Suggest that miR (show MLXIP Proteins)-377 plays an important role in the development of NSCLC by regulating AEG-1 expression.

  9. High MTDH expression is associated with multiple myeloma.

  10. In patients with non-small cell lung cancer, AEG-1 expression was an independent prognostic factor for both overall and disease-free survival.

Metadherin (MTDH) Protein Profile

Protein Summary

human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis

Alternative names and synonyms associated with Metadherin (MTDH)

  • metadherin (mtdh)
  • metadherin (MTDH)
  • metadherin (Mtdh)
  • 3D3 protein
  • 3D3/Lyric protein
  • 2610103J23Rik protein
  • AEG-1 protein
  • AEG1 protein
  • AV353288 protein
  • D8Bwg1112e protein
  • LYRIC protein
  • LYRIC/3D3 protein
  • MGC75963 protein

Protein level used designations for Metadherin Proteins (MTDH)

metadherin , LYRIC/3D3 , protein LYRIC , protein LYRIC-like , lysine-rich CEACAM1 co-isolated protein , metastasis adhesion protein , LYRIC , 3D3/LYRIC , astrocyte elevated gene-1 protein

394771 Xenopus (Silurana) tropicalis
420239 Gallus gallus
472825 Pan troglodytes
509788 Bos taurus
612147 Canis lupus familiaris
702410 Macaca mulatta
100059885 Equus caballus
100153168 Sus scrofa
100385408 Callithrix jacchus
100444491 Pongo abelii
100579266 Nomascus leucogenys
67154 Mus musculus
170910 Rattus norvegicus
92140 Homo sapiens
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