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Human MTDH Protein expressed in Human - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B Proteins)- or TNF-alpha (show TNF Proteins)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Proteins).
oncogene (show RAB1A Proteins) metadherin modulates the apoptotic pathway based on the tumor necrosis factor (show TNF Proteins) superfamily member TRAIL (Tumor Necrosis Factor (show TNF Proteins)-related Apoptosis-inducing Ligand) in breast cancer
The present findings report the novel role of AEG-1 in mediating reactive astrogliosis and in regulating astrocyte responses to injury.
our findings suggest that AEG-1 promotes mesenchymal transition in glioblastoma through the regulation of the Rho signaling pathway, resulting in tumor invasion, a primary characteristic of malignant brain tumors
these findings suggested that miR (show MLXIP Proteins)-124 was able to suppress cell proliferation, invasion and migration, as well as the EMT (show ITK Proteins) process in cervical carcinomas through directly targeting AEG-1. miR (show MLXIP Proteins)-124 and AEG-1 may be potential
Our results suggest that underexpression of miR (show MLXIP Proteins)-30a-5p might function as a tumor suppressing miRNA by directly targeting MTDH in HCC (show FAM126A Proteins) and is therefore a potential candidate biomarker for HCC (show FAM126A Proteins) targeting therapy.
MiR (show MLXIP Proteins)-136 plays a key role in temozolomide (TMZ) resistance by targeting AEG-1 in glioma cell line, suggesting that miR (show MLXIP Proteins)-136 can be used to predict a patient's response to TMZ therapy as well as serve as a novel potential maker for glioma therapy.
Data indicate metadherin (MTDH) as a direct target gene of microRNA miR (show MLXIP Proteins)-630.
AEG-1 overexpression is closely associated with epithelial-mesenchymal transition and promote metastasis in tongue squamous cell carcinoma.
MiR (show MLXIP Proteins)-30a-5p may play an essential role in the cell growth and apoptosis of hepatocellular carcinoma cells, partially via targeting AEG-1.
Suggest that miR (show MLXIP Proteins)-377 plays an important role in the development of NSCLC by regulating AEG-1 expression.
High MTDH expression is associated with multiple myeloma.
In patients with non-small cell lung cancer, AEG-1 expression was an independent prognostic factor for both overall and disease-free survival.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein