Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human MTDH Protein expressed in HEK-293 Cells - ABIN2712327
Çelik, Sajwan, Selvanathan, Marsh, Pai, Kont, Han, Minas, Rahim, Erkizan, Toretsky, Üren: Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level. in Molecular and cellular biology 2015
miR (show MLXIP Proteins)-26a is capable of suppressing the proliferation and migration of ESCC cells via negative regulation of metadherin
Mtdh is a potent modulator of podocyte apoptosis.
AEG-1 thus might play a role in NTIS associated with HCC (show FAM126A Proteins) and other cancers.
When fed a high fat and cholesterol diet (HFD), WT mice rapidly gained weight, whereas AEG-1 KO mice did not gain weight at all.
MTDH has a critical role in male fertility and the DNA repair mechanisms required for normal spermatogenesis
Data provide evidence that MTDH has a functional role in the progression and metastatic spread of ovarian cancer.
RNA-sequencing analysis identified a unique gene signature in livers of Alb (show ALB Proteins)/AEG-1/c-Myc (show MYC Proteins) mice that was not observed when either AEG-1 or c-Myc (show MYC Proteins) was overexpressed
Findings establish a pivotal role for MTDH in prostate cancer progression and metastasis.
IL-1beta (show IL1B Proteins)- or TNF-alpha (show TNF Proteins)-induced AEG-1 interaction with NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.
MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing SND1 (show SND1 Proteins).
Expression of AEG-1 was strongly associated with stem cell markers CD133 and SOX2 (show SOX2 Proteins). AEG-1 facilitated beta-catenin (show CTNNB1 Proteins) translocation into the nucleus by forming a complex with LEF1 (show LEF1 Proteins) and beta-catenin (show CTNNB1 Proteins), subsequently activating Wnt (show WNT2 Proteins) signaling downstream genes.
High MTDH expression is associated with glioblastomas.
MTDH induces Epithelial-mesenchymal transition-like change and invasion of glioma via the regulation of miR (show MLXIP Proteins)-130b-competing endogenous RNAs, providing the first direct link between MTDH and miRNAs in cancer cells.
High MTDH expression is associated with hepatocellular carcinoma.
c-Jun (show JUN Proteins) and p300 (show EP300 Proteins) are novel interacting partners of AEG-1 in gliomas.
Long noncoding RNA FTX regulated astrocyte-elevated gene-1 (AEG-1) expression through microRNA miR (show MLXIP Proteins)-342-3p.
Study highlights the importance of interactions among lncRNA HCP5, microRNA-139, and transcription factor RUNX1 in regulating the malignant behavior of glioma cells. HCP5 down-regulated miR-139 to up-regulate RUNX1. RUNX1 promoted AEG-1 expression, which was involved in a series of oncogenic effects in glioma cells. RUNX1 also up-regulated HCP5 expression, which formed a positive feedback loop.
AEG-1 is involved in miR (show MLXIP Proteins)-1297-regulated prostate cancer cell proliferation and invasion.MiR-1297 targets and inhibits AEG-1 in prostate cancer.
IL-8 (show IL8 Proteins) was displayed to be capable of directly interacting with metadherin (MTDH), which in turn can up-regulate IL-8 (show IL8 Proteins) expression.
human and mouse homologs are overexpressed in breast cancer tissue, bind to lung vasculature, and may play a role in promoting metastasis
, protein LYRIC
, protein LYRIC-like
, lysine-rich CEACAM1 co-isolated protein
, metastasis adhesion protein
, astrocyte elevated gene-1 protein