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Browse our anti-NLRP3 (NLRP3) Antibodies

Full name:
anti-NLR Family, Pyrin Domain Containing 3 Antibodies (NLRP3)
On www.antibodies-online.com are 194 NLR Family, Pyrin Domain Containing 3 (NLRP3) Antibodies from 27 different suppliers available. Additionally we are shipping NLRP3 Kits (10) and NLRP3 Proteins (4) and many more products for this protein. A total of 221 NLRP3 products are currently listed.
Synonyms:
AGTAVPRL, AII, AII/AVP, AVP, C1orf7, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, NALP3, Pypaf1
list all antibodies Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
NLRP3 287362  

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anti-Human NLRP3 Antibodies:

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Top referenced anti-NLRP3 Antibodies

  1. Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361 : Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015 (PubMed)
    Show all 7 references for ABIN1386361

  2. Human Monoclonal NLRP3 Primary Antibody for FACS, ICC - ABIN4898963 : Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016 (PubMed)
    Show all 6 references for ABIN4898963

  3. Human Monoclonal NLRP3 Primary Antibody for IHC, IHC (fro) - ABIN4340117 : Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009 (PubMed)
    Show all 3 references for ABIN4340117

  4. Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504 : Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015 (PubMed)
    Show all 2 references for ABIN652504

  5. Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577 : Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015 (PubMed)
    Show all 2 references for ABIN251577

  6. Human Polyclonal NLRP3 Primary Antibody for EIA, WB - ABIN453768 : Feldmann, Prieur, Quartier, Berquin, Certain, Cortis, Teillac-Hamel, Fischer, de Saint Basile: Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. in American journal of human genetics 2002 (PubMed)

  7. Human Polyclonal NLRP3 Primary Antibody for IHC, ELISA - ABIN185676 : Kanneganti, Ozören, Body-Malapel, Amer, Park, Franchi, Whitfield, Barchet, Colonna, Vandenabeele, Bertin, Coyle, Grant, Akira, Núñez: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. in Nature 2006 (PubMed)

  8. Human Polyclonal NLRP3 Primary Antibody for ELISA, WB - ABIN184887 : Hoffman, Mueller, Broide, Wanderer, Kolodner: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. in Nature genetics 2001 (PubMed)

More Antibodies against NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. a crosstalk between the NLRP3 inflammasome and apoptosome pathways mediated by cytochrome c (show CYCS Antibodies), whose release during apoptosis acts to limit NLRP3 inflammasome activation

  2. These results demonstrate the importance of the NLRP3 inflammasome in mediating biomass fuel smoke- and cigarette smoke-induced human bronchial epithelial cell damage and proapoptosis.

  3. both NLRP3 depletion and inhibition of K(+) efflux mitigated abacavir-induced mitochondrial reactive oxygen species production and cytotoxicity, suggesting that these processes were secondary to NLRP3 activation

  4. The p38delta (show MAPK1/3 Antibodies) mitogen-activated protein kinase (show MAPK1 Antibodies) was identified as a novel regulator of NLRP3 inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation.

  5. Inflammasome NLRP3-caspase-1 (show CASP1 Antibodies)-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  6. study demonstrated that miR (show MLXIP Antibodies)-9 could inhibit activation of the NLRP3 inflammasome and attenuate atherosclerosis-related inflammation, likely through the JAK1 (show JAK1 Antibodies)/STAT1 (show STAT1 Antibodies) signaling pathway. Therefore, miR (show MLXIP Antibodies)-9 may serve as a potential therapeutic target for atherosclerosis.

  7. Our study demonstrated the pivotal roles of NLRP3 inflammasome and downstream mediator caspase-1 (show CASP1 Antibodies) for the progress of osteo-differentiation MSCs, and offered novel therapeutic target of treatment for osteoporosis.

  8. High extracellular NaCl induces priming of the NLRP3 inflammasome in RPE (show RPE Antibodies) cells, in part via P2Y1 receptor (show P2RY1 Antibodies) signaling

  9. The (show BTK Antibodies) NLRP3 inflammasome is upregulated in activated platelets.Platelet NLRP3 promotes platelet activation, aggregation.

  10. this paper shows that negative regulation at Ser295 is critical for restraining the NLRP3 inflammasome, and identify a molecular basis for cryopyrin-associated periodic syndrome-associated NLRP3 mutations

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. Complement-induced ICH (show ACE Antibodies) neuroinflammation depended on NLRP3 activation.

  2. results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP (show TXNIP Antibodies)-NLRP3 inflammasome pathway.

  3. NLRP3 deletion protected against renal fibrosis in the 5/6 nephrectomy disease model, possibly via inhibiting mitochondrial dysfunction.

  4. age-dependent increases in alveolar macrophage mitochondrial reactive oxygen species production and NLRP3 inflammasome activation contribute to the development of experimental fibrosis.

  5. Thrombin (show F2 Antibodies) activates reactive oxygen species (ROS (show ROS1 Antibodies))/thioredoxin (show TXN Antibodies) binding protein (TXNIP (show TXNIP Antibodies))/NLRP3 signaling in BV2 (show DNAH9 Antibodies) microglia cells, which may indicate a mechanism that pro-inflammatory and pro-apoptotic contributes to the development of intracerebral hemorrhage (ICH (show ACE Antibodies)).

  6. Inflammasome NLRP3-caspase-1 (show CASP1 Antibodies)-mediated degradation of smooth muscle cell contractile proteins may contribute to aortic biomechanical dysfunction and aortic aneurysm/dissection development.

  7. Determined the minimal oligomerization state required for NLRP3 inflammasome activation. NLRP3 pyrin (show MEFV Antibodies) domain (NLRP3(PYD)) was fused to various dimerization and trimerization domains. Dimerization of the NLRP3(PYD) either in parallel or in antiparallel orientation was insufficient for the inflammasome activation. Trimerization of the NLRP3(PYD) with the foldon domain, however, induced pyroptosis and robust IL-1beta (show IL1B Antibodies) matur...

  8. The data suggest that the NLRP3 inflammasome can regulate intestinal inflammation through noncanonical mechanisms, providing additional insight as to how NLRP3 variants may contribute to the pathogenesis of CD.

  9. Btk (show BTK Antibodies) and NLRP3 co-regulate platelet activation, aggregation, and in vitro thrombus formation.

  10. NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2 (show CA2 Antibodies)+ influx.

NLRP3 Antigen Profile

Antigen Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Alternative names and synonyms associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3) antibody
  • NLR family, pyrin domain containing 3 (LOC100351623) antibody
  • NLR family, pyrin domain containing 3 (nlrp3) antibody
  • NLR family, pyrin domain containing 3 (Nlrp3) antibody
  • AGTAVPRL antibody
  • AII antibody
  • AII/AVP antibody
  • AVP antibody
  • C1orf7 antibody
  • Cias1 antibody
  • CLR1.1 antibody
  • FCAS antibody
  • FCU antibody
  • Mmig1 antibody
  • MWS antibody
  • NALP3 antibody
  • Pypaf1 antibody

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

GENE ID SPECIES
423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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