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anti-Human NLRP3 Antibodies:
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Human Polyclonal NLRP3 Primary Antibody for ICC, IF - ABIN4340123
Wang, Pan, Zhang, Wang, Kong: Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. in PLoS ONE 2012
Show all 31 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for ELISA, ICC - ABIN4340113
Chamaillard, Girardin, Viala, Philpott: Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. in Cellular microbiology 2003
Show all 11 Pubmed References
Human Monoclonal NLRP3 Primary Antibody for IHC, IP - ABIN1169100
Zhou, Tardivel, Thorens, Choi, Tschopp: Thioredoxin-interacting protein links oxidative stress to inflammasome activation. in Nature immunology 2010
Show all 8 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361
Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015
Show all 7 Pubmed References
Human Monoclonal NLRP3 Primary Antibody for CyTOF, FACS - ABIN4898963
Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016
Show all 6 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC, IHC (p) - ABIN4340115
Abdul-Sater, Koo, Häcker, Ojcius: Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. in The Journal of biological chemistry 2009
Show all 5 Pubmed References
Human Monoclonal NLRP3 Primary Antibody for IHC, IHC (fro) - ABIN4340117
Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009
Show all 3 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504
Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015
Show all 2 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN3044250
Xue, Wang, Du, Zhu: Maternal obesity induces gut inflammation and impairs gut epithelial barrier function in nonobese diabetic mice. in The Journal of nutritional biochemistry 2014
Show all 2 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577
Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015
Show all 2 Pubmed References
that NLRP3 may have specific function in the spiral ganglion neurons and can be associated with both syndromic and nonsyndromic sensorineural deafness
results firstly revealed that irisin (show FNDC5 Antibodies) mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS (show ROS1 Antibodies)-NLRP3 inflammatory signaling pathway, suggesting a likely mechanism for irisin (show FNDC5 Antibodies)-induced therapeutic effect in ischemic stroke.
Anti-dsDNA Abs activated NLRP3 inflammasome in monocytes/macrophages from systemic lupus erythematosus patients by binding to TLR4 (show TLR4 Antibodies) and inducing the production of mitochondrial reactive oxygen species.
that miR (show MLXIP Antibodies)-20b could alleviate the inflammatory response in Tuberculosis mice via targeting the NLRP3/caspase-1 (show CASP1 Antibodies)/IL-1beta (show IL1B Antibodies) pathway
level of TGF-beta1 (show TGFB1 Antibodies) was reduced after NLRP3 silencing. These results indicated that the NLRP3 inflammasome was activated in alveolar epithelial cells
SNPs in NLRP3 and CTSB (show CTSB Antibodies), associated with an increased NLRP3-inflammasome activation, are protective against the development of active pulmonary tuberculosis.
defective ribosomal products in blebs induced IL-1beta (show IL1B Antibodies) release from peripheral blood mononuclear cells or THP-1 (show GLI2 Antibodies) cells without lipopolysaccharide priming, but required the core machinery of NLRP3 inflammasomes.
besides its role in the inhibition of the NF-kappaB (show NFKB1 Antibodies) pathway, NLRC3 (show NLRC3 Antibodies) interferes with the assembly and activity of the NALP3 inflammasome complex by competing with ASC (show PYCARD Antibodies) for pro-caspase-1 (show CASP1 Antibodies) binding
uropathogenic E. coli use the multifunctional virulence factor TcpC to induce NLRP3 inflammasome expression, and attenuate innate immune responses in the urinary tract
miR (show MLXIP Antibodies)-223 limits intestinal inflammation by constraining the nlrp3 inflammasome.
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4 (show TLR4 Antibodies), which activates Nlrp3, and subsequently induces caspase-1 (show CASP1 Antibodies) activation.
Nlrp3 knock out significantly diminished the quantity of cleaved-Caspase-1 (show CASP1 Antibodies).
P50 (show LSP1 Antibodies) could interact with NLRP3 inflammasome in MCs (show SMCP Antibodies).
JNK1 (show MAPK8 Antibodies)-mediated NLRP3 phosphorylation at S194 is a critical priming event and is essential for NLRP3 inflammasome activation.
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation. Carbon monoxide suppresses the activation of glycolysis. Carbon monoxide prevents hyperglycemia-induced inflammation in vivo.
It was concluded that the HFD-instigated Nrp1 (show NRP1 Antibodies) reduction in macrophages exacerbates insulin (show INS Antibodies) resistance by promoting Nlrp3 inflammasome priming and activation.
The results indicate that the NLRP3 inflammasome links the innate recognition of S. schenckii to the adaptive immune response, so contributing to protection against this infection.
TNF (show TNF Antibodies)-driven NLRP3 expression constitutes an important checkpoint that regulates inflammasome activation, presumably by additional signals such as aging-associated damage-associated molecular pattern (DAMP (show AMPH Antibodies)).
proposed that TLR9 (show TLR9 Antibodies) regulates the NF-kappaB (show NFKB1 Antibodies)-NLRP3-IL-1beta (show IL1B Antibodies) pathway negatively in Salmonella-induced NKG2D (show KLRK1 Antibodies)-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3