Browse our anti-NLRP3 (NLRP3) Antibodies

Full name:
anti-NLR Family, Pyrin Domain Containing 3 Antibodies (NLRP3)
On www.antibodies-online.com are 220 NLR Family, Pyrin Domain Containing 3 (NLRP3) Antibodies from 27 different suppliers available. Additionally we are shipping NLRP3 Kits (10) and NLRP3 Proteins (4) and many more products for this protein. A total of 248 NLRP3 products are currently listed.
Synonyms:
AGTAVPRL, AII, AII/AVP, AVP, C1orf7, Cias1, CLR1.1, FCAS, FCU, Mmig1, MWS, NALP3, Pypaf1
list all antibodies Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
NLRP3 287362  

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Top referenced anti-NLRP3 Antibodies

  1. Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361 : Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015 (PubMed)
    Show all 7 references for 1386361

  2. Human Monoclonal NLRP3 Primary Antibody for FACS, ICC - ABIN4898963 : Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016 (PubMed)
    Show all 6 references for 4898963

  3. Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504 : Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015 (PubMed)
    Show all 2 references for 652504

  4. Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577 : Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015 (PubMed)
    Show all 2 references for 251577

  5. Human Polyclonal NLRP3 Primary Antibody for IHC, ELISA - ABIN185676 : Kanneganti, Ozören, Body-Malapel, Amer, Park, Franchi, Whitfield, Barchet, Colonna, Vandenabeele, Bertin, Coyle, Grant, Akira, Núñez: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. in Nature 2006 (PubMed)

  6. Human Polyclonal NLRP3 Primary Antibody for EIA, WB - ABIN453768 : Feldmann, Prieur, Quartier, Berquin, Certain, Cortis, Teillac-Hamel, Fischer, de Saint Basile: Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. in American journal of human genetics 2002 (PubMed)

  7. Human Polyclonal NLRP3 Primary Antibody for ELISA, IHC (p) - ABIN249728 : Hoffman, Mueller, Broide, Wanderer, Kolodner: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. in Nature genetics 2001 (PubMed)

  8. Human Monoclonal NLRP3 Primary Antibody for WB - ABIN4340119 : Dolunay, Senol, Temiz-Resitoglu, Guden, Sari, Sahan-Firat, Tunctan: Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms. in Inflammation 2016 (PubMed)

More Antibodies against NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. this is the first report describing the existence and function of the nucleotide-binding oligomerization domain-like receptor protein 3 (show HSPB3 Antibodies) inflammasome in human dendritic cells.

  2. PTPN22 (show PTPN22 Antibodies) deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).

  3. The authors further demonstrated that the upregulation of sterol regulatory element-binding protein (show CNBP Antibodies) (SREBP)-1c (show SREBF1 Antibodies) by activation of the Akt (show AKT1 Antibodies) and p70S6K (show RPS6KB1 Antibodies) pathways is critical for high-glucose-treated Porphyromonas gingivalis-induced NLRP3 expression.

  4. LFG (show FAIM2 Antibodies)-500 markedly suppresses epithelial mesenchymal transformation by inhibiting the NLRP3 inflammasome in the inflammatory microenvironment.

  5. NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from lupus nephritis (LN)patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN.

  6. lipin-2 (show LPIN2 Antibodies) as a critical player in the negative regulation of NLRP3 inflammasome.

  7. our findings support that cholesterol crystals, via stimulation of NLRP3 inflammasomes, act in synergy with the periodontal pathogen P. gingivalis to promote monocyte secretion of pro-atherogenic cytokines.

  8. results indicate that dental calculus stimulates IL-1beta (show IL1B Antibodies) secretion via NLRP3 inflammasome in human and mouse phagocytes, and that the crystalline structure has a partial role in the activation of NLRP3 inflammasome

  9. Nrf2 (show GABPA Antibodies) negatively regulating NLRP3 inflammasome activity by inhibiting the priming step and suggested that Nrf2 (show GABPA Antibodies) could be a potential target for some uncontrolled inflammasome activation-associated diseases

  10. expression of the NLRP3-CASP1 (show CASP1 Antibodies)-IL-1beta (show IL1B Antibodies) signaling pathway was markedly increased in the conjunctival lesions of patients with MU, suggesting the involvement of NLRP3 inflammasome in the onset and development of the inflammation in MU

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. PTPN22 (show PTPN22 Antibodies) deficiency resulted in pronounced colitis, increased NLRP3 phosphorylation, but reduced levels of mature IL-1beta (show IL1B Antibodies).

  2. Studied role and molecular mechanisms of NLRP3 in hyperhomocysteinemia (HHcy)-aggravated atherosclerosis; data show homocysteine (Hcy) activates NLRP3 inflammasomes in ROS (show ROS1 Antibodies)-dependent pathway in macrophages and suggest the activation of NLRP3 inflammasomes contributes to HHcy-aggravated inflammation and atherosclerosis in apoE (show APOE Antibodies)- / - mice.

  3. The results of this study suggest a novel immune modulatory strategy used by F. hepatica, whereby secretion of the FhHDM-1 peptide impairs the activation of NLRP3 by lysosomal cathepsin B (show CTSB Antibodies) protease, which prevents the downstream production of IL-1beta (show IL1B Antibodies) and the development of protective T helper 1 type immune responses that are detrimental to parasite survival.-

  4. 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-phosphocholine induce the activation of NLRP3 inflammasome.

  5. NLRP3 has a regulatory and beneficial role in herpetic stromal keratitis pathogenesis.

  6. NLRP3 inflammasomes were activated in podocytes from lupus-prone mice and from lupus nephritis (LN)patients. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN.

  7. a critical role for NLRP3 in the development of Systemic lupus erythematosus and suggests that modulating the inflammasome signal may help to control the inflammatory damage in autoimmune diseases, including lupus.

  8. NLRP3 deficiency plays a protective role by decreasing autophagy to increase phagocytosis, primarily in neutrophils.

  9. Herein, we demonstrate a novel role of Tat (show TAT Antibodies) in priming and activating NLR family pyrin domain containing 3 (NLRP3) inflammasomes in microglial cells and in HIV-Tg rats administered lipopolysaccharide. Targeting NLRP3 inflammasome pathway mediators could thus be developed as therapeutic interventions to alleviate or prevent neuroinflammation and subsequent cognitive impairment in HIV-positive patients.

  10. Clinical and experimental evidence specifically implicates NLRP3 inflammasome activation and IL-1beta (show IL1B Antibodies) responses in the pathogenesis of severe neutrophilic asthma.

NLRP3 Antigen Profile

Antigen Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Alternative names and synonyms associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3) antibody
  • NLR family, pyrin domain containing 3 (LOC100351623) antibody
  • NLR family, pyrin domain containing 3 (nlrp3) antibody
  • NLR family, pyrin domain containing 3 (Nlrp3) antibody
  • AGTAVPRL antibody
  • AII antibody
  • AII/AVP antibody
  • AVP antibody
  • C1orf7 antibody
  • Cias1 antibody
  • CLR1.1 antibody
  • FCAS antibody
  • FCU antibody
  • Mmig1 antibody
  • MWS antibody
  • NALP3 antibody
  • Pypaf1 antibody

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

GENE ID SPECIES
423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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