Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human NLRP3 Antibodies:
anti-Mouse (Murine) NLRP3 Antibodies:
anti-Rat (Rattus) NLRP3 Antibodies:
Go to our pre-filtered search.
Human Polyclonal NLRP3 Primary Antibody for ICC, IF - ABIN4340123
Wang, Pan, Zhang, Wang, Kong: Quercetin and allopurinol ameliorate kidney injury in STZ-treated rats with regulation of renal NLRP3 inflammasome activation and lipid accumulation. in PLoS ONE 2012
Show all 31 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for ELISA, ICC - ABIN4340113
Chamaillard, Girardin, Viala, Philpott: Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. in Cellular microbiology 2003
Show all 11 Pubmed References
Human Monoclonal NLRP3 Primary Antibody for IHC, IP - ABIN1169100
Zhou, Tardivel, Thorens, Choi, Tschopp: Thioredoxin-interacting protein links oxidative stress to inflammasome activation. in Nature immunology 2010
Show all 8 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361
Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015
Show all 7 Pubmed References
Human Monoclonal NLRP3 Primary Antibody for CyTOF, FACS - ABIN4898963
Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016
Show all 6 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC, IHC (p) - ABIN4340115
Abdul-Sater, Koo, Häcker, Ojcius: Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. in The Journal of biological chemistry 2009
Show all 5 Pubmed References
Human Monoclonal NLRP3 Primary Antibody for IHC, IHC (fro) - ABIN4340117
Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009
Show all 3 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577
Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015
Show all 2 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN3044250
Xue, Wang, Du, Zhu: Maternal obesity induces gut inflammation and impairs gut epithelial barrier function in nonobese diabetic mice. in The Journal of nutritional biochemistry 2014
Show all 2 Pubmed References
Human Polyclonal NLRP3 Primary Antibody for WB - ABIN3043571
Wang, Yang, Liang, Zhu, Du: Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice. in BMC complementary and alternative medicine 2014
Show all 2 Pubmed References
Our results show that Tim-3 (show HAVCR2 Antibodies) is a critical negative regulator of NLRP3 inflammasome and provides a potential target for intervention of diseases with uncontrolled inflammasome activation.
IL-27 (show IL27 Antibodies) increased NLRP3 inflammasome activation in monocytes with enhanced release of IL-1 beta (show IL1B Antibodies).
Study shows NLRP3 functionally replaces AIM2 (show AIM2 Antibodies) as the bona-fide DNA inflammasome sensor in human myeloid cells. As opposed to AIM2 (show AIM2 Antibodies), which directly binds to DNA, NLRP3 is hardwired to the upstream DNA-sensing cGAS-STING pathway to trigger inflammasome activation.
sickle red blood cell induced TLR9 (show TLR9 Antibodies), NLRP3, Caspase-1 (show CASP1 Antibodies), IL-1beta (show IL1B Antibodies) and IL-18 (show IL18 Antibodies) expression and induced IL-1beta (show IL1B Antibodies), LTB4 (show PTGR1 Antibodies) and nitrite production in PBMC cultures.
some molecules such as JNK-1 (show MAPK8 Antibodies) and ASK-1 (show MAP3K5 Antibodies) can reduce atherosclerosis through inducing apoptosis in macrophages. Notably, NLRP3 inflammasome can also cause apoptosis in macrophages, suggesting that NLRP3 inflammasome may mediate JNK (show MAPK8 Antibodies)-induced apoptosis. the role of NLRP3 in atherogenesis can be significant.
Expression of NLRP3, but not the other inflammasome components, may be associated with hepatitis B complications such as liver damage.
The present study confirms the weak clinical and functional effect of the p.Q703K variant of NLRP3.
NLRP3 inflammasome is activated in Crohn's Disease patients and in Ulcerative Colitis patients with long-standing disease.
By generating a mouse line in which the NLRP3 locus is humanized by syntenic replacement, we show the functioning of the human NLRP3 proteins in vivo, demonstrating the ability of the human inflammasome to orchestrate immune reactions in response to innate stimuli
Ethanol exposure for 24 hours or 7 days does not affect the proliferation of induced pluripotent stem cells and neural progenitor cells, but primes an innate immune-like response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway.
In dendritic cells, H. capsulatum triggers caspase-1 (show CASP1 Antibodies) activation and IL-1beta (show IL1B Antibodies) production through NLRP3 inflammasome.
Data show that inhibition of the protease activity of MALT1 (show MALT1 Antibodies) might be a strategy to treat inflammatory bowel disease and the NLRP3 inflammasome and NF-kappaB (show NFKB1 Antibodies) activation are critical components in MALT1 (show MALT1 Antibodies) signaling cascades in this disease model.
This inhibitory action of Vav2 (show VAV2 Antibodies) shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS (show ROS1 Antibodies) production. These results suggest that elevated Hcys levels activate Vav2 (show VAV2 Antibodies) and thereby increase NOX activity leading to ROS (show ROS1 Antibodies) production, which triggers NLRP3 inflammasome activation, podocyte dysfunction and glomerular injury.
Elevations of CO2 cause oligomerization of the inflammasome components ASC (show STS Antibodies), NLRP3, caspase 1 (show CASP1 Antibodies), thioredoxin interacting protein (show TXNIP Antibodies), and calreticulin (show CALR Antibodies) - a protein from endoplasmic reticulum, leading to IL-1beta (show IL1B Antibodies) synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta (show IL1B Antibodies) persists for hours after short-term exposures to elevated CO2
Results indicate CLICs (CLIC1 (show CLIC1 Antibodies), CLIC4 (show CLIC4 Antibodies) and CLIC5 (show CLIC5 Antibodies))-dependent chloride efflux as an essential and proximal upstream event for NLRP3 activation.
Results indicate that a selective and direct small-molecule inhibitor for NLRP3 inflammasome and that NLRP3 can be targeted in vivo to combat NLRP3-driven diseases.
Study demonstrated that the NLRP3 inflammasome was involved in the chronic unpredictable mild stress-induced depression-like behaviors via regulating IL-1beta (show IL1B Antibodies) protein expression in serum and hippocampus, MAPK (show MAPK1 Antibodies) pathway and NF-kappaB (show NFKB1 Antibodies) protein complex activation.
The results of this study suggests that NLRP3 inflammasome activation contribute to inflammation in hippocampus upon to deprivation of ovary.
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3