Browse our BCL6 Proteins (BCL6)

Full name:
B-Cell CLL/lymphoma 6 Proteins (BCL6)
On www.antibodies-online.com are 11 B-Cell CLL/lymphoma 6 (BCL6) Proteins from 7 different suppliers available. Additionally we are shipping BCL6 Antibodies (225) and BCL6 Kits (5) and many more products for this protein. A total of 265 BCL6 products are currently listed.
Synonyms:
BCL5, BCL6A, LAZ3, MGC132260, ZBTB27, ZNF51
list all proteins Gene Name GeneID UniProt
BCL6 12053 P41183
BCL6 604 P41182
Rat BCL6 BCL6 303836  

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BCL6 Proteins (BCL6) by Origin

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Top referenced BCL6 Proteins

  1. Human BCL6 Protein expressed in Escherichia coli (E. coli) - ABIN2005031 : Ye, Cattoretti, Shen, Zhang, Hawe, de Waard, Leung, Nouri-Shirazi, Orazi, Chaganti, Rothman, Stall, Pandolfi, Dalla-Favera: The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. in Nature genetics 1997 (PubMed)
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More Proteins for BCL6 Interaction Partners

Xenopus laevis B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Proteins)) on the promoters of selected Notch (show NOTCH1 Proteins) target genes such as enhancer of split related 1.

Mouse (Murine) B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells

  2. data provide a novel mechanism for positive control of gene expression by Bcl6, and illuminate how Bcl6 and Blimp1 (show PRDM1 Proteins) control follicular helper T cell differentiation

  3. both mouse and human B cells, IFN-gamma (show IFNG Proteins) synergized with B cell receptor, toll (show TLR4 Proteins)-like receptor, and/or CD40 (show CD40 Proteins) activation signals to promote cell-intrinsic expression of the GC master transcription factor, B cell lymphoma 6 protein.

  4. observations reveal that KLF6 (show KLF6 Proteins) repress BCL6 to enhance macrophage inflammatory gene expression and function.

  5. synergistic activity of Card11 (show CARD11 Proteins) mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model

  6. Bcl6, by interacting with the co-factors NcoR2 and HDAC3 (show HDAC3 Proteins), plays a pivotal role in controlling IRF7 (show IRF7 Proteins) induction and antiviral signaling priming.

  7. Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A Proteins) axis.

  8. Bob1 (show POU2AF1 Proteins) directly binds to and transactivate the Bcl6 promoter during the development of follicular T helper cells .

  9. upon binding to a composite NFAT (show NFATC1 Proteins)/BCL6 regulatory element within the Ccl2 (show CCL2 Proteins) promoter, NFATc1 (show NFATC1 Proteins)/beta proteins release the BCL6-dependent repression of Ccl2 (show CCL2 Proteins) gene in macrophages.

  10. transferred Bcl6-deficient T cells into wildtype hosts. Bcl6-deficient T cells did not develop into GC Tfh, but they still generated CXCR5 (show CXCR5 Proteins)+ IFN-gamma (show IFNG Proteins)+ IL-21 (show IL21 Proteins)+ IL-10 (show IL10 Proteins)+ Teff, suggesting that this predominant population is not of the Tfh-lineage

Human B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. analysis of role of BCL6 in maintaining activated B cell diffuse large B cell lymphoma reveals that ABC (show ABCB6 Proteins)-DLBCL is a BCL6-dependent disease that can be targeted by rationally designed inhibitors that exceed the binding affinity of natural BCL6 ligands

  2. Results provide evidence that BCL6 overexpression is involved in genomic instability in multiple myeloma cells.

  3. Our data reveal a regulatory role of BCL6 in inhibiting antiviral resistance factors in follicular Th cells

  4. the high expressions of BCL6 and Lewis y antigen are associated with development, high tumor burden, and worse prognosis of ovarian cancer and targeting BCL6 could be a novel therapeutic strategy for ovarian cancer treatment.

  5. both mouse and human B cells, IFN-gamma (show IFNG Proteins) synergized with B cell receptor, toll (show TLR4 Proteins)-like receptor, and/or CD40 (show CD40 Proteins) activation signals to promote cell-intrinsic expression of the GC master transcription factor, B cell lymphoma 6 protein.

  6. MicroRNA-544 down-regulates both Bcl6 and Stat3 (show STAT3 Proteins) to inhibit tumor growth of human triple negative breast cancer

  7. miR (show MLXIP Proteins)-10a directly recognizes the 3'-UTR of the BCL6 transcript and regulated BCL6 expression.

  8. This work identified BCL6 as a novel biomarker for early prediction of cerebral palsy.

  9. Bcl-6 expression in circulating follicular helper-like T cells may represent a reliable marker for the disease activity in systemic lupus erythematosus

  10. In addition, subsequent single-crystal X-ray diffraction analysis of F1324/BCL6(5-129) complex revealed that the high affinity of F1324 was caused by effective interaction of its side chains while its main chain structure was similar to that of BcoR (show BCOR Proteins)(Arg498-514Pro). To our knowledge, F1324 is the strongest BCL6-binding peptide (show HP Proteins) yet reported.

BCL6 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Alternative names and synonyms associated with BCL6

  • B-cell CLL/lymphoma 6 (bcl6)
  • B-cell CLL/lymphoma 6 (BCL6)
  • B cell leukemia/lymphoma 6 (Bcl6)
  • B-cell CLL/lymphoma 6 (Bcl6)
  • BCL5 protein
  • BCL6A protein
  • LAZ3 protein
  • MGC132260 protein
  • ZBTB27 protein
  • ZNF51 protein

Protein level used designations for B-Cell CLL/lymphoma 6 Proteins (BCL6)

B-cell CLL/lymphoma 6 , B-cell CLL/lymphoma 6 (zinc finger protein 51) , B-cell lymphoma 6 protein , zinc finger protein 51 , B-cell leukemia/lymphoma 5 , B-cell leukemia/lymphoma 6 , B-cell lymphoma 6 protein homolog , B-cell lymphoma 5 protein , B-cell lymphoma 6 protein transcript , BCL-5 , BCL-6 , cys-his2 zinc finger transcription factor , lymphoma-associated zinc finger gene on chromosome 3 , protein LAZ-3 , zinc finger and BTB domain-containing protein 27 , zinc finger transcription factor BCL6S

GENE ID SPECIES
495412 Xenopus laevis
100126063 Xenopus (Silurana) tropicalis
100294564 Pongo abelii
488124 Canis lupus familiaris
12053 Mus musculus
604 Homo sapiens
303836 Rattus norvegicus
100156549 Sus scrofa
539020 Bos taurus
101110557 Ovis aries
100353941 Oryctolagus cuniculus
424912 Gallus gallus
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