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Browse our BCL6 Proteins (BCL6)

Full name:
B-Cell CLL/lymphoma 6 Proteins (BCL6)
On are 11 B-Cell CLL/lymphoma 6 (BCL6) Proteins from 8 different suppliers available. Additionally we are shipping BCL6 Antibodies (176) and BCL6 Kits (4) and many more products for this protein. A total of 212 BCL6 products are currently listed.
BCL5, BCL6A, LAZ3, MGC132260, ZBTB27, ZNF51
list all proteins Gene Name GeneID UniProt
BCL6 12053 P41183
BCL6 604 P41182
Rat BCL6 BCL6 303836  

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BCL6 Proteins (BCL6) by Origin

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Top referenced BCL6 Proteins

  1. Human BCL6 Protein expressed in Escherichia coli (E. coli) - ABIN2005031 : Ye, Cattoretti, Shen, Zhang, Hawe, de Waard, Leung, Nouri-Shirazi, Orazi, Chaganti, Rothman, Stall, Pandolfi, Dalla-Favera: The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. in Nature genetics 1997 (PubMed)
    Show all 2 references for ABIN2005031

More Proteins for BCL6 Interaction Partners

Xenopus laevis B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. BCL6 forms a complex with BCL6 corepressor (BCoR (show BCOR Proteins)) on the promoters of selected Notch (show NOTCH1 Proteins) target genes such as enhancer of split related 1.

Mouse (Murine) B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. synergistic activity of Card11 (show CARD11 Proteins) mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model

  2. Bcl6, by interacting with the co-factors NcoR2 and HDAC3 (show HDAC3 Proteins), plays a pivotal role in controlling IRF7 (show IRF7 Proteins) induction and antiviral signaling priming.

  3. Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A Proteins) axis.

  4. Bob1 (show POU2AF1 Proteins) directly binds to and transactivate the Bcl6 promoter during the development of follicular T helper cells .

  5. upon binding to a composite NFAT (show NFATC1 Proteins)/BCL6 regulatory element within the Ccl2 (show CCL2 Proteins) promoter, NFATc1 (show NFATC1 Proteins)/beta proteins release the BCL6-dependent repression of Ccl2 (show CCL2 Proteins) gene in macrophages.

  6. transferred Bcl6-deficient T cells into wildtype hosts. Bcl6-deficient T cells did not develop into GC Tfh, but they still generated CXCR5 (show CXCR5 Proteins)+ IFN-gamma (show IFNG Proteins)+ IL-21 (show IL21 Proteins)+ IL-10 (show IL10 Proteins)+ Teff, suggesting that this predominant population is not of the Tfh-lineage

  7. Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3 (show MTA3 Proteins).

  8. Data indicate that signal transducer and activator of transcription 3 (Stat3 (show STAT3 Proteins)) can repress the expression of transcription factor Bcl6 and interleukin-4 (IL-4 (show IL4 Proteins)) in follicular helper T (TFH) cells.

  9. Enforced expression of BCL6 in EGR2 (show EGR2 Proteins)/3-deficient CD4 (show CD4 Proteins) T cells partially restored Tfh differentiation and GC formation in response to virus infection

  10. PRMT7 (show PRMT7 Proteins) could recruit H4R3me1 and symmetric H4R3me2 to the Bcl6 promoter. These results provide evidence for the important roles played by PRMT7 (show PRMT7 Proteins) in germinal center formation.

Human B-Cell CLL/lymphoma 6 (BCL6) interaction partners

  1. miR (show MLXIP Proteins)-339-5p inhibits migration and invasion in ovarian cancer by targeting NACC1 (show NACC1 Proteins) and BCL6. miR (show MLXIP Proteins)-339-5p may be a biomarker of metastasis in ovarian cancer; NACC1 (show NACC1 Proteins) had a predictive value for ovarian cancer progression

  2. Data show there was a positive correlation between B cell lymphoma 6 (Bcl-6) and B lymphocyte-induced maturation protein 1 (Blimp-1 (show PRDM1 Proteins)) at the level of mRNA.

  3. miR (show MLXIP Proteins)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6/cyclin D2 (show CCND2 Proteins) axis.

  4. BCL6 Rearrangements are associated with Diffuse Large B-Cell Lymphoma.

  5. Bcl6, by interacting with the co-factors NcoR2 and HDAC3 (show HDAC3 Proteins), plays a pivotal role in controlling IRF7 (show IRF7 Proteins) induction and antiviral signaling priming.

  6. diffuse large B-cell lymphoma patients with either MYC (show MYC Proteins)/BCL6 rearrangements or MYC (show MYC Proteins)/BCL6 co-expression did not always have poorer prognosis

  7. BCL6 promotes proliferation and survival of trophoblastic cells.

  8. Studies indicate that germinal centers (GC) B (show NPR2 Proteins) cells represent the normal counterpart of most B-cell lymphomas, which are often characterized by deregulated B cell lymphoma 6 (BCL6) expression or BCL6-mediated pathways.

  9. Bcl-6 mRNA and protein levels, as well as the frequencies of Bcl-6(+)CD4 (show CD4 Proteins)(+) cells were significantly increased in polyp tissues compared with normal controls.

  10. Follicular helper T cells differentiation is a multistage process involving BCL6 and other transcription factors, cytokines, and costimulation through ICOS (show CTLA4 Proteins) and several other molecules. (Review)

BCL6 Protein Profile

Protein Summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Alternative names and synonyms associated with BCL6

  • B-cell CLL/lymphoma 6 (bcl6)
  • B-cell CLL/lymphoma 6 (BCL6)
  • B cell leukemia/lymphoma 6 (Bcl6)
  • B-cell CLL/lymphoma 6 (Bcl6)
  • BCL5 protein
  • BCL6A protein
  • LAZ3 protein
  • MGC132260 protein
  • ZBTB27 protein
  • ZNF51 protein

Protein level used designations for B-Cell CLL/lymphoma 6 Proteins (BCL6)

B-cell CLL/lymphoma 6 , B-cell CLL/lymphoma 6 (zinc finger protein 51) , B-cell lymphoma 6 protein , zinc finger protein 51 , B-cell leukemia/lymphoma 5 , B-cell leukemia/lymphoma 6 , B-cell lymphoma 6 protein homolog , B-cell lymphoma 5 protein , B-cell lymphoma 6 protein transcript , BCL-5 , BCL-6 , cys-his2 zinc finger transcription factor , lymphoma-associated zinc finger gene on chromosome 3 , protein LAZ-3 , zinc finger and BTB domain-containing protein 27 , zinc finger transcription factor BCL6S

495412 Xenopus laevis
100126063 Xenopus (Silurana) tropicalis
100294564 Pongo abelii
488124 Canis lupus familiaris
12053 Mus musculus
604 Homo sapiens
303836 Rattus norvegicus
100156549 Sus scrofa
539020 Bos taurus
101110557 Ovis aries
100353941 Oryctolagus cuniculus
424912 Gallus gallus
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