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The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4 (show RBBP4 Proteins)/RBBP7 (show RBBP7 Proteins).
Results showed that in the development of colon cancer, MTA1 is linked to certain signal pathways, such as Wnt/Notch/nucleotide excision repair pathways. The findings also suggested that MTA1 demonstrates the closest relationship in a coregulation process with the key molecules AKT1, EP300, CREBBP, SMARCA4, RHOA, and CAD.
elevated expression of MTA1 was significantly correlated with recurrence, and was an independent risk factor for lymph node metastasis in gastric cancer
the augmentation of endogenous MTA1 expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha (show ESR1 Proteins) and BCL2 (show BCL2 Proteins) pathways.
show that AR might be an additional marker for endocrine responsiveness in ER(+) cancers and suggests that blocking MTA1 might be an effective way to inhibit AR/HER2 (show ERBB2 Proteins) signaling in ER(-) breast cancer
Suppression of breast cancer metastasis occurs following miR (show MLXIP Proteins)-421 inhibition of MTA1 expression.
There is no interaction between IGFBP3 (show IGFBP3 Proteins) and MTA1 in ESCC, and they are not independent risk factors for esophageal squamous cell carcinoma prognosis.
Findings highlight MTA1 as a key upstream regulator of prostate tumorigenesis and cancer progression.
the significance of MTA1 expression in the invasion and metastasis of medulloblastoma
MTA1 expression is upregulated in tumours compared to normal colon cancer samples.
Inhibition of MTA1 expression by in vivo siRNA treatment exacerbated the pathology of LPS (show TLR4 Proteins)-induced acute lung injury, by selectively promoting the expression of NF-kappaB (show NFKB1 Proteins)-regulated inflammatory cytokines.
MTA1 was regulated by HIF-1alpha (show HIF1A Proteins) in hypoxia circumstance to suppress osteoblast differentiation.
MTA1 levels were increased in monosodium urate crystal-induced inflammation.
The inhibition of MTA1 gene could depress the growth and metastasis of laryngeal squamous cell carcinoma in nude mice.
Data suggest that nuclear metastasis-associated protein 1 (MTA1) is a good marker for cancer differentiation diagnosis and a potential target for the treatment of cancers.
this study reports the potential signaling events related to up-regulation of metastasis associated protein 1 (Mta1), a master chromatin modifier, during mono-(2-ethylhexyl) phthalate (MEHP)-induced Sertoli cells injury.
MTA1 has an important role in the maintenance of circadian rhythmicity.
the MTA1/NFkappaB/FasL (show FASL Proteins) circuit may serve as an important defensive/repairing mechanism to help to control the germ cell quality after Sertoli cell injury.
Findings suggest that Mta3-NuRD complex, inclding component HDAC1 (show HDAC1 Proteins), is essential for the initiation of primitive hematopoiesis.
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene.
metastasis associated gene 1 protein
, metastasis-associated protein MTA1
, metastasis associated family, member 3
, metastasis-associated protein MTA3