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Our results demonstrated that MTA3 overexpression contributes to colorectal cancer carcinogenesis, progression, and chemoresistance. MTA3 could serve as a potential therapeutic target in colorectal cancer
Studies indicate that metastasis associated family, member 3 protein (MTA3) is expressed in various tissues and is associated with different physiological functions, and appears to play more complicated roles in cancers.
MTA3 suppress apoptosis of A549 an H157 cells by inhibiting BAX (show BAX Proteins), PARP expression.
This review focuses on the current knowledge about the function and regulation of MTA1 (show MTA1 Proteins) and MTA3 proteins in gynecological cancer, including ovarian, endometrial, and cervical tumors.
MAT3 over-expression in non-small cell lung carcinoma and MAT3 mRNA level is a risk factor for lymph node metastasis and survival.
Using western blotting and luciferase assays, MTA3 was identified as a target of miR (show MLXIP Proteins)-495
MTA3 expression is an independent prognostic factor in patients with gastroesophageal junction adenocarcinoma.
Down-regulation of MTA3 and up-regulation of CGB5 (show CGB Proteins) and Snail (show SNAI1 Proteins) are associated with preeclampsia.
MTA3 is not a useful marker to assess and identify high-risk patients with endometrial adenocarcinomas
The absence of MTA3 leads to aberrant expression of Snail (show SNAI1 Proteins), a master regulator of epithelial to mesenchymal transitions. This results in loss of expression of E-cadherin (show CDH1 Proteins), causing changes in epithelial architecture and invasive growth.
Bcl6 (show BCL6 Proteins) middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Metastasis-associated protein 3 (show HSPB3 Proteins) (MTA3) regulates G2/M progression in proliferating mouse granulosa cells.
These results demonstrate the importance of FOG-2/MTA (show DNMT1 Proteins)/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG (show APAF1 Proteins) repression motif and the NuRD complex.
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (By similarity).
metastasis associated 1 family, member 3
, metastasis associated 3
, metastasis-associated protein MTA3-like
, metastasis associated family, member 3
, metastasis associated gene family, member 3
, metastasis-associated protein MTA3