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the Bj1 RanGEF promotes Prospero (show PROX1 Proteins) nuclear export and neuroblast self-renewal
crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 A resolution, providing an atomic view of how a chromatin protein interacts with the histone and DNA components of the nucleosome
Data show that dRCC1 is required for nuclear import of nuclear localization signal sequence (NLS (show ALDH1A2 Proteins))-carrying cargo molecules and for cell proliferation and/or survival during germline, eye and wing development and that dRCC1 appears to facilitate apoptosis.
this study has demonstrated that EBNA1 (show EBNA-1 Proteins) and RCC1 closely associate on the chromosomes during metaphase, suggesting an essential role for the interaction during this phase, perhaps in tethering EBNA1 (show EBNA-1 Proteins) to mitotic chromosomes.
RCC1 expression enables the proliferation of cells that sustain DNA damage. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
RCC1 expression is frequently lost in poorly differentiated gastric cell lines and gastric carcinoma tissues. Loss of RCC1 expression is correlated with tumor differentiation and depth of invasion.
stress can disrupt the Ran gradients through RCC1-dependent and RCC1-independent mechanisms
PI3Kbeta regulates the nuclear envelope through upstream regulation of RCC1 and Ran
RCC1 facilitates a tight binding between the encephalomyocarditis virus leader and cellular Ran GTPase (show RAN Proteins).
RCC1 can induce bipolar spindle formation. Remarkably, RCC1 beads oscillate within spindles from pole to pole, a behavior that could be converted to a more typical, stable association by the addition of a kinesin together with RCC1.
discovery of the first alpha-N-methyltransferase, which we named N-terminal RCC1 methyltransferase (NRMT (show METTL11A Proteins)).
The authors find that RCC1 uses a conformationally flexible loop region we have termed the switchback loop in addition to its N-terminal tail to bind to the nucleosome.
RanBP3 (show RANBP3 Proteins) associates with the Ran-specific guanine nucleotide exchange factor (show RASGRF1 Proteins), regulator of chromosome condensation 1 (RCC1).
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly.
chromosome condensation 1
, regulator of chromosome condensation
, regulator of chromosome condensation 1
, RCC1 protein
, in excess
, possible fragment of potential guanine nucleotide exchange factor
, SNHG3-RCC1 readthrough transcript
, cell cycle regulatory protein
, guanine nucleotide-releasing protein
, chromosome condensation protein 1