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Splicing Factor 3b, Subunit 1, 155kDa Proteins (SF3B1)
On www.antibodies-online.com are 3 Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) Proteins from 2 different suppliers available. Additionally we are shipping SF3B1 Antibodies (67) and SF3B1 Kits (1) and many more products for this protein. A total of 79 SF3B1 products are currently listed.
Synonyms:
155kDa, 2810001M05Rik, AA409119, Hsh155, MDS, PRP10, PRPF10, sap155, SF3B1, SF3b155, TA-8, Targ4, wu:fb99f09
list all proteins Gene Name GeneID UniProt
SF3B1 81898  
Rat SF3B1 SF3B1 84486  
SF3B1 23451 O75533

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SF3B1 Proteins (SF3B1) by Origin

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Zebrafish Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

  1. Data indicate that splicing factor 3b (show SF3B14 Proteins), subunit 1 (sf3b1) mutation causes aberrant splicing of sf3b1 resulting in functional and predicted non-functional transcripts and a 90% reduction in full-length Sf3b1 protein.

Mouse (Murine) Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

  1. Our findings demonstrate that, despite significant differences in affected transcripts, there is overlap in the phenotypes associated with SF3B1-K700E between human and mouse.

  2. Sf3b1(K700E) mice develop macrocytic anemia due to a term (show TCN2 Proteins)inal erythroid maturation defect, erythroid dysplasia, and long-term hematopoietic stem cell (LT-HSC) expansion.

  3. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Proteins)) activation of SF3B1 and SF3B1-mediated splice switching of KHK (show KHK Proteins)-A to KHK (show KHK Proteins)-C

  4. Sf3b1 isrequired for the blastocyst formation.

  5. SF3B1 plays an important role in the regulation of hematopoietic stem cells, whereas SF3B1 haploinsufficiency itself is not associated with the myelodysplastic syndrome phenotype with ring sideroblasts.

  6. The level of Sf3b1 expression is critical for the proliferative capacity of hematopoietic stem cells. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.

  7. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.

  8. the active spliceosome, containing SAP155 phosphorylated by DYRKIA, performs pre-mRNA splicing in spermatogonia during testicular development

  9. active spliceosome, containing phosphorylated SAP155, performs pre-mRNA splicing on chromatin concomitant with transcription during testicular development.

  10. Sf3b1 and Polycomb (show CBX2 Proteins) group (PcG) proteins interaction is essential for true PcG-mediated repression of Hox (show MSH2 Proteins) genes.

Human Splicing Factor 3b, Subunit 1, 155kDa (SF3B1) interaction partners

  1. Mutation in SF3B1 (show SF3B2 Proteins) gene is associated with Uveal Melanoma.

  2. Mutation in SF3B1 (show SF3B2 Proteins) is associated with myelodysplastic syndrome and chronic lymphocytic leukemia.

  3. different HSH155 alleles elicit disparate effects on splicing: some increase the fidelity of BS selection while others decrease fidelity. Our data support a model wherein conformational changes in SF3b1 (show SF3B2 Proteins) promote U2 association with the BS independently of the action of the DEAD-box ATPase Prp5. We propose that SF3b1 (show SF3B2 Proteins) functions to stabilize weak U2/BS duplexes to drive spliceosome assembly and splicing

  4. mutations of SF3B1 (show SF3B2 Proteins) may block erythropoiesis via dysregulation of alternative RNA splicing of transcription factor TAL1 (show TAL1 Proteins)

  5. Inhibition of SF3B1 (show SF3B2 Proteins) with moderate levels of Pladienolide B, a previously established small molecule inhibitor of SF3B1 (show SF3B2 Proteins), affects the transcriptional activation of HSF1 (show HSF1 Proteins), the transcription factor that mediates the heat shock response.

  6. Our findings demonstrate that, despite significant differences in affected transcripts, there is overlap in the phenotypes associated with SF3B1 (show SF3B2 Proteins)-K700E between human and mouse.

  7. Sf3b1 (show SF3B2 Proteins)(K700E). Sf3b1 (show SF3B2 Proteins)(K700E) mice develop macrocytic anemia (show TCN2 Proteins) due to a terminal erythroid maturation defect, erythroid dysplasia, and long-term hematopoietic stem cell (LT-HSC (show FUT1 Proteins)) expansion.

  8. The blood sample from a patient with lung cancer with a known SF3B1 (show SF3B2 Proteins) V701F mutation was also analyzed and this mutation was successfully identified in ptDNA. However, 1 of the patients with a K700E mutation was found to have a mutational burden of 98%.

  9. data support a model in which cycloheximide -induced downregulation of the iron exporter ABCB7 (show ABCB7 Proteins) mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 (show SF3B2 Proteins) underlies the increased mitochondrial iron accumulation found in MDS (show PAFAH1B1 Proteins) patients with ring sideroblasts

  10. recent insights into the molecular mechanisms of mis (show AMH Proteins)-splicing caused by mutant SF3B1 (show SF3B2 Proteins) and the pathogenesis of RSs (show GRB10 Proteins) in the context of congenital sideroblastic anemia as well as anemia with ringed sideroblasts with SF3B1 (show SF3B2 Proteins) mutations.

SF3B1 Protein Profile

Protein Summary

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with SF3B1

  • splicing factor 3b, subunit 1, 155kDa (SF3B1)
  • splicing factor 3b, subunit 1, 155kDa (sf3b1)
  • splicing factor 3b, subunit 1 (sf3b1)
  • splicing factor 3b, subunit 1 (Sf3b1)
  • 155kDa protein
  • 2810001M05Rik protein
  • AA409119 protein
  • Hsh155 protein
  • MDS protein
  • PRP10 protein
  • PRPF10 protein
  • sap155 protein
  • SF3B1 protein
  • SF3b155 protein
  • TA-8 protein
  • Targ4 protein
  • wu:fb99f09 protein

Protein level used designations for SF3B1

splicing factor 3b, subunit 1, 155kDa , splicing factor 3B subunit 1 , splicing factor 3B subunit 1-like , tst , SAP 155 , pre-mRNA-splicing factor SF3b 155 kDa subunit , spliceosome-associated protein 155 , splicing factor 3b, subunit 1, 155 kDa , transforming growth factor alpha regulated gene 4 , splicing factor 3b, subunit 1, 155kD , 146 kDa nuclear protein , SF3b155 , pre-mRNA processing 10 , pre-mRNA splicing factor SF3b, 155 kDa subunit

GENE ID SPECIES
459850 Pan troglodytes
510177 Bos taurus
697773 Macaca mulatta
100022236 Monodelphis domestica
100070506 Equus caballus
100413687 Callithrix jacchus
100477819 Ailuropoda melanoleuca
100547422 Meleagris gallopavo
100559157 Anolis carolinensis
100604147 Nomascus leucogenys
446117 Danio rerio
81898 Mus musculus
84486 Rattus norvegicus
399336 Xenopus laevis
424056 Gallus gallus
23451 Homo sapiens
488456 Canis lupus familiaris
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