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Human C5 Protein expressed in Escherichia coli (E. coli) - ABIN2003124
Gerard, Gerard: C5A anaphylatoxin and its seven transmembrane-segment receptor. in Annual review of immunology 1994
Show all 5 references for ABIN2003124
In an arterial thrombosis model, plasminogen activator administration increased C5a levels. Overall, these findings suggest plasmin bridges thrombosis and the immune response by liberating C5a and inducing MAC assembly.
C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 (show IL6 Proteins) production)
C5a can induce the expression of TLR4 (show TLR4 Proteins) in retinal pigment epithelial cells.
sublingual immunotherapy for Japanese cedar pollinosis affects levels of IL-17A (show IL17A Proteins) and complement components 3a and 5a
These results identify complement activation product C5a as a priming signal for RPE (show RPE Proteins) cells that allows for subsequent inflammasome activation by stimuli such as lipofuscin-mediated photooxidative damage.
a significant up-regulation (173 fold increase, p < 0.0001) in the expression of inflammatory complement component 5 (C5) in endometriosis was detected for the first time.
Data show that combined inhibition of complement 3 and 5 and CD14 antigen (show CD14 Proteins) significantly reduced E. coli-induced cytokines.
Rs2900180 in C5-TRAF1 (show TRAF1 Proteins) and linked variants in a 66Kb region were associated with radiographic progression in ACPA (show PRTN3 Proteins)-negative RA
The C5 rs2269067 GG genotype confers risk for AAU in a Chinese population and is associated with an elevated C5 serum concentration and an increased IL-17 (show IL17A Proteins) production.
TRAF1 (show TRAF1 Proteins)/C5 rs10818488 polymorphism is not a genetic risk factor for acquired aplastic anemia in a Chinese population.
We induced anti-myeloperoxidase (show MPO Proteins) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (show IL17A Proteins)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Data (including data from studies in knockout mice) suggest that C5aR/C5aR (show C5AR1 Proteins) (complement C5a/anaphylatoxin C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.
Carboxypeptidase B2 (show CPB2 Proteins) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.
our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (show C5AR1 Proteins), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.
C5a signaling increases the expression of the chemokine (show CCL1 Proteins) monocyte chemoattractant protein-1 (show CCL2 Proteins) in hepatic metastases of colon cancer
Properdin (show CFB Proteins) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (show IL6 Proteins)-dependent manner.
C5a produced during lung injury binds to C5aR (show C5AR1 Proteins) in alveolar macrophages, initiates downstream signaling that promotes autophagy.
Protein kinase C-delta (show PKCd Proteins) mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator (show PLAU Proteins) signaling in macrophages
This work reveals an essential role for C5L2 in C5a-triggered, AP2 (show TFAP2A Proteins)-dependent C5aR (show C5AR1 Proteins) internalization and downstream ERK (show EPHB2 Proteins) signaling.
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
complement component 5
, similar to complement component C5-1
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, complement C5
, complement component C5
, complement C5a anaphylatoxin