Browse our C5A Proteins (C5a)

Full name:
Complement Component 5a Proteins (C5a)
On are 19 Complement Component 5a (C5a) Proteins from 8 different suppliers available. Additionally we are shipping C5A Kits (96) and C5A Antibodies (50) and many more products for this protein. A total of 165 C5A products are currently listed.
C5, C5A, C5AR, C5b, C5R1, CD88, CPAMD4, Hc, He, RGD1561905
list all proteins Gene Name GeneID UniProt
C5a 362119  
C5a 727 P01031
C5a 15139 P06684

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C5A Proteins (C5a) by Origin

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Top referenced C5A Proteins

  1. Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2180666 : Monk, Scola, Madala, Fairlie: Function, structure and therapeutic potential of complement C5a receptors. in British journal of pharmacology 2007 (PubMed)
    Show all 3 references for 2180666

  2. Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921 : Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005 (PubMed)
    Show all 2 references for 2506921

  3. Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104 : Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011 (PubMed)
    Show all 2 references for 413104

More Proteins for C5A Interaction Partners

Human Complement Component 5a (C5a) interaction partners

  1. Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (show IL8 Proteins) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (show IL8 Proteins) expression via PI3K (show PIK3CA Proteins) and MEK (show MAP2K1 Proteins). Study demonstrated expression of IL-8 (show IL8 Proteins) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.

  2. Reducing RPS19 (show RPS19 Proteins) in tumor cells or blocking the C5a receptor 1-RPS19 (show RPS19 Proteins) interaction decreases RPS19 (show RPS19 Proteins)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer

  3. C5aR (show C5AR1 Proteins) expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.

  4. this study shows that downregulation of CD88 (show C5AR1 Proteins) after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults

  5. Relation of C5aR (show C5AR1 Proteins) expression to tumor development and poor prognosis of the breast cancer patients

  6. In an arterial thrombosis model, plasminogen activator administration increased C5a levels. Overall, these findings suggest plasmin bridges thrombosis and the immune response by liberating C5a and inducing MAC assembly.

  7. The objective of the present study was to validate a receptor occupancy (RO) assay for a human anti-C5aR (show C5AR1 Proteins) monoclonal antibody drug candidate, NNC0215-0384 (NN0384)

  8. These data thus suggest that C5aR1 acts as an enhancer of CCR5-mediated HIV entry into macrophages, the targeting of which may prove useful to reduce HIV infection by R5 strains.

  9. C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.

  10. C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 (show IL6 Proteins) production)

Mouse (Murine) Complement Component 5a (C5a) interaction partners

  1. n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (show CASP3 Proteins) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.

  2. The C5a/C5aR pathway is essential for up-regulating SphK1 (show SPHK1 Proteins) expression through p38 MAPK (show MAPK14 Proteins) activation in acute liver mice.

  3. We induced anti-myeloperoxidase (show MPO Proteins) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease

  4. Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (show IL17A Proteins)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.

  5. Data (including data from studies in knockout mice) suggest that C5aR/C5aR (show C5AR1 Proteins) (complement C5a/anaphylatoxin (show C5 Proteins) C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.

  6. Carboxypeptidase B2 (show CPB2 Proteins) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.

  7. our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (show C5AR1 Proteins), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.

  8. C5a signaling increases the expression of the chemokine (show CCL1 Proteins) monocyte chemoattractant protein-1 (show CCL2 Proteins) in hepatic metastases of colon cancer

  9. Properdin (show CFB Proteins) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (show IL6 Proteins)-dependent manner.

  10. C5a produced during lung injury binds to C5aR (show C5AR1 Proteins) in alveolar macrophages, initiates downstream signaling that promotes autophagy.

C5A (C5a) Protein Profile

Protein Summary

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Alternative names and synonyms associated with C5A (C5a)

  • complement component 5 (C5)
  • complement component 5a receptor 1 (C5AR1)
  • hemolytic complement (Hc)
  • C5 protein
  • C5A protein
  • C5AR protein
  • C5b protein
  • C5R1 protein
  • CD88 protein
  • CPAMD4 protein
  • Hc protein
  • He protein
  • RGD1561905 protein

Protein level used designations for Complement Component 5a Proteins (C5a)

anaphylatoxin , complement C5 , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 , C5a anaphylatoxin , anaphylatoxin C5a analog , prepro-C5 , C5a anaphylatoxin chemotactic receptor 1 , C5a anaphylatoxin receptor , C5a ligand , C5a-R , complement component 5 receptor 1

362119 Rattus norvegicus
727 Homo sapiens
728 Homo sapiens
15139 Mus musculus
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