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Browse our C5A Proteins (C5a)

Full name:
Complement Component 5a Proteins (C5a)
On are 20 Complement Component 5a (C5a) Proteins from 9 different suppliers available. Additionally we are shipping C5A Kits (79) and C5A Antibodies (44) and many more products for this protein. A total of 143 C5A products are currently listed.
C5, C5A, C5AR, C5b, C5R1, CD88, CPAMD4, Hc, He, RGD1561905
list all proteins Gene Name GeneID UniProt
C5a 362119  
C5a 727 P01031
C5a 15139 P06684

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C5A Proteins (C5a) by Origin

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Top referenced C5A Proteins

  1. Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2180666 : Monk, Scola, Madala, Fairlie: Function, structure and therapeutic potential of complement C5a receptors. in British journal of pharmacology 2007 (PubMed)
    Show all 3 references for ABIN2180666

  2. Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN413098 : Nonaka, Bao, Matsumura, Götze, Kandasamy, Kononov, Broide, Nakayama, Seeberger, Fukuda: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)
    Show all 2 references for ABIN413098

  3. Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921 : Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005 (PubMed)
    Show all 2 references for ABIN2506921

  4. Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104 : Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011 (PubMed)
    Show all 2 references for ABIN413104

More Proteins for C5A Interaction Partners

Human Complement Component 5a (C5a) interaction partners

  1. C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.

  2. C5 rs2269067 GG genotype confers risk for proliferative diabetic retinopathy of type 2 diabetes in Chinese Han population (associated with an elevated C5 mRNA expression and an increased IL-6 (show IL6 Proteins) production)

  3. that C5aR stimulates cell invasion and migration via ERK1/2-mediated epithelial-mesenchymal transition in hepatocellular carcinoma cells

  4. C5a can induce the expression of TLR4 (show TLR4 Proteins) in retinal pigment epithelial cells.

  5. sublingual immunotherapy for Japanese cedar pollinosis affects levels of IL-17A (show IL17A Proteins) and complement components 3a and 5a

  6. Inhibition of C5aR1 (show C5AR1 Proteins) leads to a significant reduction of CD66b and CD11b (show ITGAM Proteins) expression indicating a lower neutrophil activation status and block of granule exocytosis.

  7. These results identify complement activation product C5a as a priming signal for RPE (show RPE Proteins) cells that allows for subsequent inflammasome activation by stimuli such as lipofuscin-mediated photooxidative damage.

  8. a significant up-regulation (173 fold increase, p < 0.0001) in the expression of inflammatory complement component 5 (show C5 Proteins) (C5) in endometriosis was detected for the first time.

  9. that rs10853784 of C5aR1 gene are associated with coronary artery disease in Han population of China

  10. 96.7% of the metastatic RCCs had C5aR expression, vs. 50.5% of the non-metastatic ones. C5a triggered ERK- and PI3Kdependent invasion of the C5aR-expressing renal carcinoma cells. The C5a-C5aR axis plays a crucial role in renal carcinoma cell invasion.

Mouse (Murine) Complement Component 5a (C5a) interaction partners

  1. Data (including data from studies in knockout mice) suggest that C5aR/C5aR (show C5AR1 Proteins) (complement C5a/anaphylatoxin (show C5 Proteins) C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.

  2. Carboxypeptidase B2 (show CPB2 Proteins) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.

  3. our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (show C5AR1 Proteins), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.

  4. C5a signaling increases the expression of the chemokine (show CCL1 Proteins) monocyte chemoattractant protein-1 (show CCL2 Proteins) in hepatic metastases of colon cancer

  5. Properdin (show CFB Proteins) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (show IL6 Proteins)-dependent manner.

  6. C5a produced during lung injury binds to C5aR (show C5AR1 Proteins) in alveolar macrophages, initiates downstream signaling that promotes autophagy.

  7. Protein kinase C-delta (show PKCd Proteins) mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator (show PLAU Proteins) signaling in macrophages

  8. This work reveals an essential role for C5L2 in C5a-triggered, AP2 (show TFAP2A Proteins)-dependent C5aR (show C5AR1 Proteins) internalization and downstream ERK (show EPHB2 Proteins) signaling.

  9. IFN-gamma (show IFNG Proteins)-producing NKT (show CTSL1 Proteins) cells enhance C5a generation via IL-10 (show IL10 Proteins)-mediated inhibition of CD55 (show CD55 Proteins) expression on neutrophils, thereby exacerbating sepsis.

  10. Mouse susceptibility to MHV-3-induced fulminant hepatitis may rely on C5a/C5aR interactions, for which ERK1/2 and p38 (show CRK Proteins) pathways participate in up-regulating Fgl2 (show FGL2 Proteins) expression.

C5A (C5a) Protein Profile

Protein Summary

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Alternative names and synonyms associated with C5A (C5a)

  • complement component 5 (C5)
  • complement component 5a receptor 1 (C5AR1)
  • hemolytic complement (Hc)
  • C5 protein
  • C5A protein
  • C5AR protein
  • C5b protein
  • C5R1 protein
  • CD88 protein
  • CPAMD4 protein
  • Hc protein
  • He protein
  • RGD1561905 protein

Protein level used designations for Complement Component 5a Proteins (C5a)

anaphylatoxin , complement C5 , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 , C5a anaphylatoxin , anaphylatoxin C5a analog , prepro-C5 , C5a anaphylatoxin chemotactic receptor 1 , C5a anaphylatoxin receptor , C5a ligand , C5a-R , complement component 5 receptor 1

362119 Rattus norvegicus
727 Homo sapiens
728 Homo sapiens
15139 Mus musculus
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