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Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104
Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011
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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN413098
Nonaka, Bao, Matsumura, Götze, Kandasamy, Kononov, Broide, Nakayama, Seeberger, Fukuda: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. in Proceedings of the National Academy of Sciences of the United States of America 2014
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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921
Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005
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Studies indicate that the complement response lie the active fragments, C3a (show C3 Proteins) and C5a, acting through their specific receptors, C3aR (show C3AR1 Proteins), C5aR1 (show C5AR1 Proteins) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (show C5 Proteins) (C5) after binding to eculizumab in vivo.
TLR4 (show TLR4 Proteins) and C5aR (show C5AR1 Proteins) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Proteins), PI3Kbeta, SGK1 (show SGK1 Proteins), and FOXO (show FOXO3 Proteins) transcription factors.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (show S100A8 Proteins).
Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (show IL8 Proteins) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (show IL8 Proteins) expression via PI3K (show PIK3CA Proteins) and MEK (show MAP2K1 Proteins). Study demonstrated expression of IL-8 (show IL8 Proteins) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.
Reducing RPS19 (show RPS19 Proteins) in tumor cells or blocking the C5a receptor 1-RPS19 (show RPS19 Proteins) interaction decreases RPS19 (show RPS19 Proteins)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer
C5aR (show C5AR1 Proteins) expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.
this study shows that downregulation of CD88 (show C5AR1 Proteins) after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (show AKT1 Proteins) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (show AKT1 Proteins) in heart.
n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (show CASP3 Proteins) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.
The C5a/C5aR pathway is essential for up-regulating SphK1 (show SPHK1 Proteins) expression through p38 MAPK (show MAPK14 Proteins) activation in acute liver failure.in mice.
We induced anti-myeloperoxidase (show MPO Proteins) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (show IL17A Proteins)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Data (including data from studies in knockout mice) suggest that C5aR/C5aR (show C5AR1 Proteins) (complement C5a/anaphylatoxin (show C5 Proteins) C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.
Carboxypeptidase B2 (show CPB2 Proteins) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.
our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (show C5AR1 Proteins), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.
C5a signaling increases the expression of the chemokine (show CCL1 Proteins) monocyte chemoattractant protein-1 (show CCL2 Proteins) in hepatic metastases of colon cancer
Properdin (show CFB Proteins) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (show IL6 Proteins)-dependent manner.
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
, complement C5
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, C5a anaphylatoxin chemotactic receptor 1
, C5a anaphylatoxin receptor
, C5a ligand
, complement component 5 receptor 1