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Browse our Complement Factor H Proteins (CFH)

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Complement Factor H Proteins (CFH)
On www.antibodies-online.com are 19 Complement Factor H (CFH) Proteins from 7 different suppliers available. Additionally we are shipping Complement Factor H Antibodies (257) and Complement Factor H Kits (56) and many more products for this protein. A total of 341 Complement Factor H products are currently listed.
Synonyms:
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, fH, FHL1, HF, HF1, HF2, HUS, im:7147412, Mud-1, NOM, Sas-1, Sas1, si:ch211-207o17.2
list all proteins Gene Name GeneID UniProt
CFH 12628 P06909
CFH 3075 P08603
CFH 155012  

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Complement Factor H Proteins (CFH) by Origin

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Top referenced Complement Factor H Proteins

  1. Human Complement Factor H Protein expressed in Human Cells - ABIN2003293 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 5 references for ABIN2003293

More Proteins for Complement Factor H Interaction Partners

Chimpanzee Complement Factor H (CFH) interaction partners

  1. interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]

Zebrafish Complement Factor H (CFH) interaction partners

  1. Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (show CFHR1 Proteins)-4) in Danio rerio.

Mouse (Murine) Complement Factor H (CFH) interaction partners

  1. environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.

  2. absence of plasma CfH conferred susceptibility to glomerulonephritis

  3. This new understanding of the complicated interactions of CFH in AMD (show AMD1 Proteins)-like pathology provides an improved foundation for the development of targeted therapies for AMD (show AMD1 Proteins)

  4. data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.

  5. Cfh and Cfhr2 (show CFHR2 Proteins) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.

  6. A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.

  7. Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (show MASP1 Proteins) did not ameliorate either the plasma Complement C3 (show C3 Proteins) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  8. A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B (show CFB Proteins) expression), favoring increased complement activation and lipofuscin deposition in the outer retina.

  9. The exaggerated humoral immune response in CFH(-/-) mice was normalized in CFH(-/-)C5aR (show C5AR1 Proteins)(-/-) double knockout mice, highlighting the C5aR (show C5AR1 Proteins) dependence.

  10. Properdin (show CFB Proteins) deficiency exacerbated renal injury in mice lacking complement factor H.

Human Complement Factor H (CFH) interaction partners

  1. Our results show that age-related macular degeneration donors carrying the high risk allele for CFH (C) had significantly more mtDNA damage compared with donors having the wild-type genetic profile.

  2. Data suggest that Staphylococcus aureus surface protein SdrE (serine-aspartate repeat protein E (show CRISP1 Proteins)) functions as a 'clamp (show PDZK1 Proteins)' to capture C-terminal tail of human CFH (complement factor H) at a specific ligand-binding site/groove via unique close-dock-lock-latch mechanism and thereby sequesters CFH on surface of S. aureus for complement evasion (immune evasion).

  3. The haplotypic coinheritance of potentially functional variants (including missense variants, novel splice sites, and the CFHR3-CFHR1 (show CFHR1 Proteins) deletion) was described for the four common haplotypes. Expression of the short and long CFH transcripts differed markedly between the retina and liver.

  4. Data suggest that complement factor H (CFH) attaches to surface of host cells to inhibit complement activation and amplification, preventing destruction of the host cells; SdrE (serine-aspartate repeat protein) of Staphylococcus aureus binds to CFH allowing S. aureus to mimic a host cell and reducing bacterial killing by granulocytes. [Commentary]

  5. Interaction effects between supplement groups and individual complement factor H (CFH) Y402H and age-related maculopathy susceptibility 2 (ARMS2 (show ARMS2 Proteins)) genotypes, and composite genetic risk groups combining the number of risk alleles for both loci, were evaluated for their association with progression

  6. EMD (show EMD Proteins) were not AMD (show AMD1 Proteins)-independently associated with CFH or ARMS2 (show ARMS2 Proteins) genotypes. Our results indicate that patients without AMD (show AMD1 Proteins) but with EMD (show EMD Proteins) can serve as controls in studies evaluating AMD (show AMD1 Proteins) risk factors.

  7. Despite limited power of this pilot study, our results suggest an association of HF with polymorphisms in ARMS2 (show ARMS2 Proteins)/HTRA1 (show HTRA1 Proteins), CFH, APOE4/TOMM40 (show TOMM40 Proteins), and VEGFA (show VEGFA Proteins) genes which could be triggered by modification of the extracellular matrix, altered complement system or lipid metabolism.

  8. data suggest that R1210C is a unique C-terminal complement factor H mutation that behaves as a partial complement factor H deficiency, predisposing individuals to diverse pathologies with distinct underlying pathogenic mechanisms; the final disease outcome is then determined by R1210C-independent genetic risk factors

  9. AMD (show AMD1 Proteins) progression rate is influenced by CFH, and suggest that variants within CFH may have different effects on risk versus progression. However, since CFH:rs10737680 was not significant after Bonferroni correction and explained only a relatively small portion of variation in progression rate beyond that explained by age

  10. We describe a novel CFH/CFHR3 hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated end joining rather than nonallelic homologous recombination. We confirmed a transcript from this hybrid gene and showed a secreted protein product that lacks the recognition domain of factor H and exhibits impaired cell surface complement regulation

Pig (Porcine) Complement Factor H (CFH) interaction partners

Complement Factor H (CFH) Protein Profile

Protein Summary

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Complement Factor H (CFH)

  • complement factor H (CFH)
  • complement factor H (cfh)
  • complement component factor h (Cfh)
  • complement factor H (Cfh)
  • AHUS1 protein
  • AMBP1 protein
  • ARMD4 protein
  • ARMS1 protein
  • CFH protein
  • CFHL3 protein
  • fH protein
  • FHL1 protein
  • HF protein
  • HF1 protein
  • HF2 protein
  • HUS protein
  • im:7147412 protein
  • Mud-1 protein
  • NOM protein
  • Sas-1 protein
  • Sas1 protein
  • si:ch211-207o17.2 protein

Protein level used designations for Complement Factor H Proteins (CFH)

complement factor H , complement factor H related protein 3A4/5G4 , protein beta-1-H , H factor 1 (complement) , H factor 2 (complement) , adrenomedullin binding protein , age-related maculopathy susceptibility 1 , beta-1-H-globulin , beta-1H , factor H , factor H-like 1 , complement component factor H , complement inhibitory factor H , platelet complement factor H , complement regulator factor H

GENE ID SPECIES
457601 Pan troglodytes
553060 Danio rerio
553297 Danio rerio
100399888 Callithrix jacchus
100451270 Pongo abelii
100465619 Ailuropoda melanoleuca
100600041 Nomascus leucogenys
12628 Mus musculus
3075 Homo sapiens
100051358 Equus caballus
155012 Rattus norvegicus
478952 Canis lupus familiaris
100733902 Cavia porcellus
100340175 Oryctolagus cuniculus
397525 Sus scrofa
280816 Bos taurus
429057 Gallus gallus
100174982 Ovis aries
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