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interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]
Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (show CFHR1 Proteins)-4) in Danio rerio.
Factor H and Crry (show CR1L Proteins) are critical for regulating complement activation at distinct anatomic sites within the kidney.
VEGF (show VEGFA Proteins) inhibition decreases local CFH and other complement regulators in the eye and kidney through reduced VEGFR2 (show KDR Proteins)/PKC-alpha (show PKCa Proteins)/CREB (show CREB1 Proteins) signaling.
environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.
absence of plasma CfH conferred susceptibility to glomerulonephritis
This new understanding of the complicated interactions of CFH in AMD (show AMD1 Proteins)-like pathology provides an improved foundation for the development of targeted therapies for AMD (show AMD1 Proteins)
data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.
Cfh and Cfhr2 (show CFHR2 Proteins) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.
A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.
Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (show MASP1 Proteins) did not ameliorate either the plasma Complement C3 (show C3 Proteins) (C3) activation or glomerular C3 accumulation in FH-deficient mice.
A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B (show CFB Proteins) expression), favoring increased complement activation and lipofuscin deposition in the outer retina.
Identification of rare CFH variant carriers may be important for upcoming complement-inhibiting therapies. Patients with an extensive drusen area, drusen with crystalline appearance, and drusen nasal to the optic disc are more likely to have a rare variant in the CFH gene.
C-reactive protein (show CRP Proteins) amino acids 35-47 mediate the interaction with complement factor H in lupus nephritis
OCT (show Plxna2 Proteins) scans revealed lower retinal thickness in patients homozygous for CFH or ARMS2 (show ARMS2 Proteins), which was caused by a significantly reduced photoreceptor layer. The number and ultrastructure of drusen were also significantly different.
CFH rs1061170 has an important effect on age at onset of MDD in Han Chinese and may therefore be related to early pathogenesis of MDD.
Data suggest that disease-linked mutations in complement factor H (CFH) affect pivotal role of CFH in regulation of complement activation; mutations studied include those linked to atypical hemolytic uremic syndrome and age-related macular degeneration.
Fibrinogen gamma chain (show FGG Proteins) and complement factor H were found to be bound as a protein complex in the plasma of a patient with advanced ovarian cancer
Factor I binds C3b-Factor H between Factor H domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.
The VEGF (show VEGFA Proteins) haplotype TGA (show TBX1 Proteins) could be used as a marker for poor visual prognosis in Tunisian patients with neovascular AMD (show AMD1 Proteins) treated with bevacizumab.
Two protective, low-frequency, non-synonymous variants were significantly associated with a decrease in age-related macular degeneration (AMD (show AMD1 Proteins))risk: A307V in PELI3 (show PELI3 Proteins) and N1050Y in CFH .We also identified a strong protective signal for a common variant (rs8056814) near CTRB1 associated with a decrease in AMD (show AMD1 Proteins) risk (logistic regression: OR = 0.71, P = 1.8 x 10-07).
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
complement factor H
, complement factor H related protein 3A4/5G4
, protein beta-1-H
, H factor 1 (complement)
, H factor 2 (complement)
, adrenomedullin binding protein
, age-related maculopathy susceptibility 1
, factor H
, factor H-like 1
, complement component factor H
, complement inhibitory factor H
, platelet complement factor H
, complement regulator factor H