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Browse our Complement Factor H Proteins (CFH)

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Complement Factor H Proteins (CFH)
On are 19 Complement Factor H (CFH) Proteins from 8 different suppliers available. Additionally we are shipping Complement Factor H Antibodies (258) and Complement Factor H Kits (48) and many more products for this protein. A total of 335 Complement Factor H products are currently listed.
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, fH, FHL1, HF, HF1, HF2, HUS, im:7147412, Mud-1, NOM, Sas-1, Sas1, si:ch211-207o17.2
list all proteins Gene Name GeneID UniProt
CFH 12628 P06909
CFH 3075 P08603
CFH 155012  

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Complement Factor H Proteins (CFH) by Origin

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Top referenced Complement Factor H Proteins

  1. Human Complement Factor H Protein expressed in Human Cells - ABIN2003293 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)
    Show all 5 references for ABIN2003293

More Proteins for Complement Factor H Interaction Partners

Chimpanzee Complement Factor H (CFH) interaction partners

  1. interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]

Zebrafish Complement Factor H (CFH) interaction partners

  1. Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (show CFHR1 Proteins)-4) in Danio rerio.

Mouse (Murine) Complement Factor H (CFH) interaction partners

  1. absence of plasma CfH conferred susceptibility to glomerulonephritis

  2. This new understanding of the complicated interactions of CFH in AMD (show AMD1 Proteins)-like pathology provides an improved foundation for the development of targeted therapies for AMD (show AMD1 Proteins)

  3. data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.

  4. Cfh and Cfhr2 (show CFHR2 Proteins) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.

  5. A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.

  6. Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (show MASP1 Proteins) did not ameliorate either the plasma Complement C3 (show C3 Proteins) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  7. A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B (show CFB Proteins) expression), favoring increased complement activation and lipofuscin deposition in the outer retina.

  8. The exaggerated humoral immune response in CFH(-/-) mice was normalized in CFH(-/-)C5aR (show C5AR1 Proteins)(-/-) double knockout mice, highlighting the C5aR (show C5AR1 Proteins) dependence.

  9. Properdin (show CFB Proteins) deficiency exacerbated renal injury in mice lacking complement factor H.

  10. IL-27 (show IL27 Proteins) regulates complement activation through up-regulation of complement factor H in the retina.

Human Complement Factor H (CFH) interaction partners

  1. The results of western blotting revealed that the protein expression levels of FH and FHL1 (show FHL1 Proteins) were not regulated by IL6 (show IL6 Proteins) and IL8 (show IL8 Proteins) in a dosedependent manner. Immunofluorescence analysis confirmed that the A2780 ovarian cancer cell line expressed both membrane bound and intracellular forms of FH and FHL1 (show FHL1 Proteins).

  2. CFH Y402H SNP might be protective for AMD in the Turkish population. VEGF rs2146323 and rs699947 SNPs have no relationship to exudative AMD formation, and none of these seem to have any effect on anti-VEGF response.

  3. AG genotype of CCL2 (show CCL2 Proteins)-2518 in combination with TT genotype of CFH Y402H showed significant protective effect against age-related macular degeneration.

  4. The polymorphism rs1061170/Y402H might be a genetic predictor of treatment response to anti-VEGF (show VEGFA Proteins) therapy in AMD (show AMD1 Proteins) patients.

  5. In this article, the authors investigated the use of complement inhibitor factor H (FH) on complement activation and showed good efficacy. The results would therefore suggest the potential application of complement inhibitor in the future

  6. These findings were supported by in vivo observations from CFH(-/-) MRL-lpr (show FAS Proteins) mice, which exhibited higher levels of circulating nucleosomes and necrotic cells than their CFH(+/+) littermates.

  7. association between CFH gene polymorphism and response to ranibizumab in Brazilian patients with neovascular age-related macular degeneration

  8. We identified a novel missense mutation, CFH P139A, for which the G allele contributed 13 of 1061 reads from the pooled DNA.

  9. innate immune regulator complement Factor H (FH) binds a previously not reported GM1 conformation that is not compatible with the GM1-binding sites of other structurally characterized GM1-binding lectins such as the Simian Virus 40 (SV40) capsid.

  10. CFH -543G>A, A473A, -257C>T, and IVS15 polymorphisms might be moderately associated with Macular Degeneration risk (Meta-Analysis)

Pig (Porcine) Complement Factor H (CFH) interaction partners

Complement Factor H (CFH) Protein Profile

Protein Summary

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Complement Factor H (CFH)

  • complement factor H (CFH)
  • complement factor H (cfh)
  • complement component factor h (Cfh)
  • complement factor H (Cfh)
  • AHUS1 protein
  • AMBP1 protein
  • ARMD4 protein
  • ARMS1 protein
  • CFH protein
  • CFHL3 protein
  • fH protein
  • FHL1 protein
  • HF protein
  • HF1 protein
  • HF2 protein
  • HUS protein
  • im:7147412 protein
  • Mud-1 protein
  • NOM protein
  • Sas-1 protein
  • Sas1 protein
  • si:ch211-207o17.2 protein

Protein level used designations for Complement Factor H Proteins (CFH)

complement factor H , complement factor H related protein 3A4/5G4 , protein beta-1-H , H factor 1 (complement) , H factor 2 (complement) , adrenomedullin binding protein , age-related maculopathy susceptibility 1 , beta-1-H-globulin , beta-1H , factor H , factor H-like 1 , complement component factor H , complement inhibitory factor H , platelet complement factor H , complement regulator factor H

457601 Pan troglodytes
553060 Danio rerio
553297 Danio rerio
100399888 Callithrix jacchus
100451270 Pongo abelii
100465619 Ailuropoda melanoleuca
100600041 Nomascus leucogenys
12628 Mus musculus
3075 Homo sapiens
100051358 Equus caballus
155012 Rattus norvegicus
478952 Canis lupus familiaris
100733902 Cavia porcellus
100340175 Oryctolagus cuniculus
397525 Sus scrofa
280816 Bos taurus
429057 Gallus gallus
100174982 Ovis aries
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