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Human Kallikrein 7 ELISA Kit for Sandwich ELISA - ABIN415095
Heiker, Klöting, Kovacs, Kuettner, Sträter, Schultz, Kern, Stumvoll, Blüher, Beck-Sickinger: Vaspin inhibits kallikrein 7 by serpin mechanism. in Cellular and molecular life sciences : CMLS 2013
Show all 2 references for ABIN415095
Ablation of KLK7 is not sufficient to rescue the lethal effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5 completely rescues Netherton Syndrome-like phenotype.
Higher hK7 expression is associated with cervical adenocarcinomas
Prolonged Klk7 neutralization provokes profound abnormalities in Klk7 function, due to pH-induced high serine protease (show F2 ELISA Kits) activity that degrades lipid processing enzymes and corneodesmosomes proteins.
Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells
Korean X-linked ichthyosis (show LBR ELISA Kits) patients exhibited unimpaired skin barrier function and frequent association with the KLK7 gene polymorphism, which may differentiate them from Western X-linked ichthyosis (show LBR ELISA Kits) patients.
This report demonstrates that concurrent loss of KLK5 (show KLK5 ELISA Kits) and KLK7 associates with a poor clinical outcome in Squamous-Cell Carcinoma and could therefore serve as prognostic marker in this disease.
Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival.
Our findings suggest that serum KLK7 may be a valuable diagnostic biomarker for cervical cancer, and may help to determine the individual prognosis of these patients.
KLK6 (show KLK1 ELISA Kits) and KLK7 mRNA and protein overexpression is directly associated with early-stage ovarian tumors.
Proteolytic cleavage of midkine (show MDK ELISA Kits), CYR61 (show CYR61 ELISA Kits), and tenascin-C (show TNC ELISA Kits) govern the pathophysiological roles of KLK7.
Early-stage oral squamous cell carcinoma and high KLK7 mRNA levels were correlated with the rs10581213(wt/ins + ins/ins (show INS ELISA Kits)) genotypes
These results demonstrate the aberrant expression of KLK7 in colon cancer cells and tissues and its involvement in cell proliferation in vitro and in vivo.
Daata indicate that the peptide Abz-NLY( downward arrow)RVE-Q-EDDnp is the best synthetic substrate for Kallikrein-related peptidase 7 (KLK7) [kcat/Km=455 (mMs)(-1)].
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.
kallikrein 7 (chymotryptic, stratum corneum)
, protease, serine, 6
, serine protease 6
, stratum corneum chymotryptic enzyme
, kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
, signal protein