Browse our MASP1 Proteins (MASP1)

Full name:
Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) Proteins (MASP1)
On www.antibodies-online.com are 22 Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) Proteins from 6 different suppliers available. Additionally we are shipping MASP1 Antibodies (75) and MASP1 Kits (19) and many more products for this protein. A total of 124 MASP1 products are currently listed.
Synonyms:
3MC1, AW048060, CCPII, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRF
list all proteins Gene Name GeneID UniProt
MASP1 17174 P98064
MASP1 5648 P48740

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MASP1 Proteins (MASP1) by Origin

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More Proteins for MASP1 Interaction Partners

Mouse (Murine) Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) interaction partners

  1. MBL (show MBL2 Proteins)-KO (Figure 1a) and MASP-1-KO (Figure 1b) mice are poor mobilizers in response to mobilizing agents compared with WT littermates

  2. this study shows that inhibition of MASP-1/3 by gene silencing is sufficient to ameliorate collagen Ab-induced arthritis in mice

  3. MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice

  4. study provides conclusive evidence that an intact complement LP is essential to initiate CAIA, and that MAp44 may be an appropriate treatment for inflammatory arthritis.

  5. Data indicate that co-deficiency of factor H (FH (show CFH Proteins)) and MASP-1/MASP-3 did not ameliorate either the plasma Complement C3 (show C3 Proteins) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  6. Within the mannose-binding lectin (show MBL2 Proteins)/MASP complex, MASP-1 is the necessary complement component for thrombin (show F2 Proteins)-like activity in vitro.

  7. We conclude that MASP-1 does not require binding to mannose binding lectins or ficolins to activate the alternative pathway of complement

  8. we investigated the mechanism of MASP-3 activation and its substrate using the recombinant mouse MASP-3 (rMASP-3) and several different types of MASP-deficient mice

  9. Our studies demonstrate for the first time, to our knowledge, the absolute requirement for the activity of MASP-1 protein in autoimmune-associated inflammatory tissue injury

  10. MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways.

Human Mannan-Binding Lectin serine Peptidase 1 (C4/C2 Activating Component of Ra-Reactive Factor) (MASP1) interaction partners

  1. Our finding suggests that complement MASP-1 can increase adhesion between neutrophils and endothelial cells in a direct fashion

  2. Study discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1 (show THBS1 Proteins), GPLD1 (show GPLD1 Proteins) and ApoA-IV (show APOA4 Proteins), suggesting a role for these proteins in the pathophysiology of type 2 diabetes.

  3. MASP-1 plasma levels were higher among patients with type 2 diabetes and diabetic mice

  4. MASP-1 was not associated with adverse cardiovascular outcomes in diabetics.

  5. high serum CL-L1 (show COLEC10 Proteins) concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration

  6. The exclusion of the MASP1 and COLEC11 (show COLEC11 Proteins) Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome

  7. Plasma MASP-1 concentration at the early stage of Kawasaki disease is predictive of length of time of recovery from coronary artery lesions.

  8. MASP-1 and MASP-2 (show MASP2 Proteins) are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation.

  9. described for the first time a detailed model of prothrombin (show F2 Proteins) activation by MASP-1

  10. Fusion of MAP-1 with FH domains represents a novel therapeutic approach for selective targeting upstream and central complement activation at sites of inflammation

MASP1 Protein Profile

Protein Summary

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with MASP1

  • mannan-binding lectin serine peptidase 1 (Masp1)
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (MASP1)
  • 3MC1 protein
  • AW048060 protein
  • CCPII protein
  • CRARF protein
  • CRARF1 protein
  • MAP1 protein
  • MAp44 protein
  • MASP protein
  • Masp1/3 protein
  • MASP3 protein
  • PRSS5 protein
  • RaRF protein

Protein level used designations for MASP1

MASP-1 , complement factor MASP-3 , complement-activating component of Ra-reactive factor , mannan-binding lectin serine protease 1 , mannose-binding lectin-associated serine protease 1 , mannose-binding protein-associated serine protease , ra-reactive factor serine protease p100 , raRF , serine protease 5 , Ra-reactive factor serine protease p100

GENE ID SPECIES
17174 Mus musculus
5648 Homo sapiens
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