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MASP1 Products

(Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Categories

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].

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Featured MASP1 Categories

MASP1 Antibodies

High quality antibodies with extensive validation data.

MASP1 ELISA Kits

Reliable ELISA kits for a wide range of species.

MASP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MASP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF (p), IHC (p), WB
Validations
  • (2)
Cat. No. ABIN733508
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (2)
Cat. No. ABIN519328
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN7187251
Quantity 100 μg
Datasheet Datasheet

Recommended MASP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6957634
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957635
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968437
Quantity 96 tests
Datasheet Datasheet

Recommended MASP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3083569
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3121282
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093757
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MASP1 products

Wang, Liu, Ye, Jiang, Yu, Xu, Du, Ma, Cao, Yuan, Shen, Lin, Zhang, Li: "Plasma proteome profiling of high-altitude polycythemia using TMT-based quantitative proteomics approach." in: Journal of proteomics, Vol. 194, pp. 60-69, (2020) (PubMed).

Klassert, Goyal, Stock, Driesch, Hussain, Berrocal-Almanza, Myakala, Sumanlatha, Valluri, Ahmed, Schumann, Flores, Slevogt: "AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in MASP1 Associated with Pulmonary Tuberculosis in an Indian Population." in: Frontiers in immunology, Vol. 9, pp. 242, (2019) (PubMed).

Kasanmoentalib, Valls Seron, Ferwerda, Tanck, Zwinderman, Baas, van der Ende, Brouwer, van de Beek: "Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 2, (2017) (PubMed).

Hansen, Csuka, Munthe-Fog, Varga, Farkas, Hansen, Koch, Skjødt, Garred, Skjoedt: "The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 8, pp. 3596-604, (2015) (PubMed).

Radu, Hu, Jiang, Bok: "Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype." in: The Journal of biological chemistry, Vol. 289, Issue 13, pp. 9113-20, (2014) (PubMed).

Hajela, Kojima, Ambrus, Wong, Moffatt, Ferluga, Hajela, Gál, Sim: "The biological functions of MBL-associated serine proteases (MASPs)." in: Immunobiology, Vol. 205, Issue 4-5, pp. 467-75, (2002) (PubMed).

Endo, Takahashi, Kuraya, Matsushita, Stover, Schwaeble, Fujita: "Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter." in: International immunology, Vol. 14, Issue 10, pp. 1193-201, (2002) (PubMed).

Kuraya, Matsushita, Endo, Thiel, Fujita: "Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G." in: International immunology, Vol. 15, Issue 1, pp. 109-17, (2002) (PubMed).

Schwaeble, Dahl, Thiel, Stover, Jensenius: "The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes." in: Immunobiology, Vol. 205, Issue 4-5, pp. 455-66, (2002) (PubMed).

Matsushita, Kuraya, Hamasaki, Tsujimura, Shiraki, Fujita: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, (2002) (PubMed).

Synonyms and alternative names related to MASP1

mannan-binding lectin serine peptidase 1 (Masp1), mannan binding lectin serine peptidase 1 (MASP1), 3MC1, AW048060, CCPII, Crarf, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRF

Protein level used designations for MASP1

  • MASP-1
  • complement factor MASP-3
  • complement-activating component of Ra-reactive factor
  • mannan-binding lectin serine protease 1
  • mannose-binding lectin-associated serine protease 1
  • mannose-binding protein-associated serine protease
  • ra-reactive factor serine protease p100
  • raRF
  • serine protease 5
  • Ra-reactive factor serine protease p100
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