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Browse our MLH1 Proteins (MLH1)

Full name:
MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Proteins (MLH1)
On www.antibodies-online.com are 6 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Proteins from 4 different suppliers available. Additionally we are shipping MLH1 Antibodies (175) and MLH1 Kits (1) and many more products for this protein. A total of 189 MLH1 products are currently listed.
Synonyms:
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301
list all proteins Gene Name GeneID UniProt
MLH1 17350 Q9JK91
MLH1 4292 P40692
MLH1 81685 P97679

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MLH1 Proteins (MLH1) by Origin

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More Proteins for MLH1 Interaction Partners

Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Results suggest that Xenopus MBD4 (show MBD4 Proteins)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1, msh2 (show MSH2 Proteins), and msh6 (show MSH6 Proteins), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected

  2. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  3. these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (show HTT Proteins) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  4. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  5. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  6. suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Proteins) partner PMS2 (show PMS2 Proteins)

  7. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Proteins) and brain tumour multicellular spheroids.

  8. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  9. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Proteins) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

  10. Ablation of Mlh1 did not appreciably influence the developmental phenotypes conferred by the absence of Rad51d (show RAD51D Proteins).

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. These results demonstrate the role of variant rs1800734 in altering transcription factor binding as well as epigenetics at regions beyond the MLH1 CpG island in which it is located.

  2. Results indicate that MLH1-hypermethylated BRAF wild-type colorectal carcinomas can harbor KRAS mutations and arise from precursor polyps resembling conventional tubular/tubulovillous adenomas.

  3. There were a 61.7% (95/154) overexpression of DNMT3B (show DNMT3B Proteins), 50.0% (77/154) loss of PTEN expression and 18.2% (28/154) loss of hMLH1 expression in endometrial carcinomas.

  4. demonstrates that lower level of histone acetylation and specific histone methylation such as H3K36me3 correlate with aberrant transcripts in hMLH1 exon 10-11 region

  5. revealed high frequencies of gene promoter methylation in NSCLCs: 84 % for DLEC1 and MLH1 and 57 % for ITGA9

  6. In colorectal neoplasms, negative expression of the MMR (show MRC1 Proteins) proteins MLH1, MSH2 (show MSH2 Proteins) or MSH6 (show MSH6 Proteins) was seen in 15% (47 of 313) of the patients. Defect MLH1 was most common and detected in 12% of the cases. Defect MLH1 and MSH2 (show MSH2 Proteins) were identified in each patient's normal adjacent mucosa.

  7. Microsatellite instability Gastroesophageal junction carcinoma revealed increased mutation rates of genes encoding hypermethylation, including MLH1 promoter.

  8. The expression of genes and proteins related to DNA repair mechanism MLH1, MSH2 (show MSH2 Proteins) and ATM (show ATM Proteins) in the normal oral mucosa of chronic smokers was reduced.

  9. The expression of genes and proteins related to DNA repair mechanism MLH1, MSH2 (show MSH2 Proteins) and ATM (show ATM Proteins) in the normal oral mucosa of chronic smokers was reduced.

  10. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 in 40%, MSH2 (show MSH2 Proteins) in 36%, MSH6 (show MSH6 Proteins) in 18% and PMS2 (show PMS2 Proteins) in 6% of the families

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Protein Profile

Protein Summary

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)
  • CG11482 gene product from transcript CG11482-RB (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198)
  • mutL homolog 1 (E. coli) (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1)
  • 1110035C23Rik protein
  • AI317206 protein
  • AI325952 protein
  • AI561766 protein
  • CG11482 protein
  • COCA2 protein
  • Dmel\\CG11482 protein
  • dmlh-1 protein
  • dmlh1 protein
  • FCC2 protein
  • hMLH1 protein
  • HNPCC protein
  • HNPCC2 protein
  • LOC100232198 protein
  • MLH1 protein
  • zgc:66301 protein

Protein level used designations for MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

GENE ID SPECIES
420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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