Browse our MLH1 Proteins (MLH1)

Full name:
MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Proteins (MLH1)
On www.antibodies-online.com are 6 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Proteins from 4 different suppliers available. Additionally we are shipping MLH1 Antibodies (175) and MLH1 Kits (1) and many more products for this protein. A total of 189 MLH1 products are currently listed.
Synonyms:
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301
list all proteins Gene Name GeneID UniProt
MLH1 17350 Q9JK91
MLH1 4292 P40692
MLH1 81685 P97679

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MLH1 Proteins (MLH1) by Origin

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More Proteins for MLH1 Interaction Partners

Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Results suggest that Xenopus MBD4 (show MBD4 Proteins)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1, msh2 (show MSH2 Proteins), and msh6 (show MSH6 Proteins), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  2. high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected

  3. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  4. these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (show HTT Proteins) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  5. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  6. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  7. suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Proteins) partner PMS2 (show PMS2 Proteins)

  8. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Proteins) and brain tumour multicellular spheroids.

  9. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  10. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Proteins) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Data suggest that yeast Mlh1-Mlh3 heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1-Mlh3 heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1-PMS2 (show PMS2 Proteins) exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 (show PMS2 Proteins) = post meiotic segregation increased 2 protein)

  2. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  3. Genetic changes between MLH1 and MSH2 (show MSH2 Proteins) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (show MSH2 Proteins) and DVL3 (show DVL3 Proteins) genes (p = 0.034).

  4. Mismatch repair (MMR (show MRC1 Proteins))-deficient endometrial carcinomas have significantly increased tumoral and immune stromal PD-L1 (show CD274 Proteins) expression relative to MMR (show MRC1 Proteins)-intact carcinomas. PD-L1 (show CD274 Proteins) is frequently positive in both tumoral and immune cells at the periphery of MMR (show MRC1 Proteins)-deficient tumors. Lynch syndrome-associated tumors are more likely to express PDL1 (show CD274 Proteins) relative to sporadic MLH1 promoter hypermethylation carcinomas.

  5. These results demonstrate the role of variant rs1800734 in altering transcription factor binding as well as epigenetics at regions beyond the MLH1 CpG island in which it is located.

  6. Results indicate that MLH1-hypermethylated BRAF wild-type colorectal carcinomas can harbor KRAS mutations and arise from precursor polyps resembling conventional tubular/tubulovillous adenomas.

  7. There were a 61.7% (95/154) overexpression of DNMT3B (show DNMT3B Proteins), 50.0% (77/154) loss of PTEN expression and 18.2% (28/154) loss of hMLH1 expression in endometrial carcinomas.

  8. demonstrates that lower level of histone acetylation and specific histone methylation such as H3K36me3 correlate with aberrant transcripts in hMLH1 exon 10-11 region

  9. revealed high frequencies of gene promoter methylation in NSCLCs: 84 % for DLEC1 and MLH1 and 57 % for ITGA9

  10. In colorectal neoplasms, negative expression of the MMR (show MRC1 Proteins) proteins MLH1, MSH2 (show MSH2 Proteins) or MSH6 (show MSH6 Proteins) was seen in 15% (47 of 313) of the patients. Defect MLH1 was most common and detected in 12% of the cases. Defect MLH1 and MSH2 (show MSH2 Proteins) were identified in each patient's normal adjacent mucosa.

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Protein Profile

Protein Summary

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)
  • CG11482 gene product from transcript CG11482-RB (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198)
  • mutL homolog 1 (E. coli) (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1)
  • 1110035C23Rik protein
  • AI317206 protein
  • AI325952 protein
  • AI561766 protein
  • CG11482 protein
  • COCA2 protein
  • Dmel\\CG11482 protein
  • dmlh-1 protein
  • dmlh1 protein
  • FCC2 protein
  • hMLH1 protein
  • HNPCC protein
  • HNPCC2 protein
  • LOC100232198 protein
  • MLH1 protein
  • zgc:66301 protein

Protein level used designations for MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

GENE ID SPECIES
420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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