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Browse our MLH1 Proteins (MLH1)

Full name:
MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Proteins (MLH1)
On are 6 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Proteins from 4 different suppliers available. Additionally we are shipping MLH1 Antibodies (172) and MLH1 Kits (2) and many more products for this protein. A total of 187 MLH1 products are currently listed.
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301
list all proteins Gene Name GeneID UniProt
MLH1 17350 Q9JK91
MLH1 4292 P40692
MLH1 81685 P97679

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MLH1 Proteins (MLH1) by Origin

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Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Results suggest that Xenopus MBD4 (show MBD4 Proteins)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1, msh2 (show MSH2 Proteins), and msh6 (show MSH6 Proteins), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  2. these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (show HTT Proteins) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  3. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  4. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  5. suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR (show MRC1 Proteins) partner PMS2 (show PMS2 Proteins)

  6. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (show ARHGEF16 Proteins) and brain tumour multicellular spheroids.

  7. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  8. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (show MRC1 Proteins) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

  9. Ablation of Mlh1 did not appreciably influence the developmental phenotypes conferred by the absence of Rad51d (show RAD51D Proteins).

  10. Role for mismatch repair proteins Msh2 (show MSH2 Proteins), Mlh1, and Pms2 (show PMS2 Proteins) in immunoglobulin class switching shown by sequence analysis of recombination junctions.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Loss of MLH1 expression was however observed in none of those including four Microsatellite instability + tumours . Expression of MSH2 (show MSH2 Proteins), another essential MMR (show MRC1 Proteins) gene, was also examined, but no alterations were found

  2. Individuals who carry a MMR (show MRC1 Proteins) gene (MLH1, MSH2 (show MSH2 Proteins), PMS2 (show PMS2 Proteins) or MSH6 (show MSH6 Proteins)) mutation are at an increased risk of developing cancers at multiple sites, most notably colorectal and endometrial carcinomas.

  3. The DNA methylation (show HELLS Proteins) of both Reprimo and hMLH1 genes depressed the protein expression, and may participate in the occurrence and progression and gastric cancer

  4. data supported an interdependence of mismatch repair proteins, particularly MLH1 and MSH2 (show MSH2 Proteins), in the mediation of apoptosis in human colorectal carcinoma cell lines

  5. MLH1 Promoter Region Methylation is associated with colorectal cancer.

  6. In Lynch syndrome families, prostate cancer was associated with mutations in MLH1 with loss of the mismatch repair protein (show MSH2 Proteins).

  7. DAPK-1 (show DAPK1 Proteins) and MLH1 methylation correlated inversely in tumors in the middle-third of the stomach

  8. Loss of MLH-1/PMS-2 (show PMS2 Proteins) expression was associated with right-colon location, poor and mucinous differentiation and dense lymphocytic infiltration in colorectal adenocarcinoma.

  9. Pathogenic mutations were only confined to MLH1 and identified in 28.8% of Singapore families with Hereditary Colorectal Cancer.

  10. Data indicate tumor suppressors TP73 (show TP73 Proteins), RASSF1A (show RASSF1 Proteins), MLH1 and BRCA1 as possible biomarkers to distinguish Pleomorphic invasive lobular cancer (pleomorphic ILC (show CCL27 Proteins)} from classic ILC (show CCL27 Proteins) and infiltrative ductal cancer (IDC (show LMNA Proteins)).

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) interaction partners

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Protein Profile

Protein Summary

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)
  • CG11482 gene product from transcript CG11482-RB (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198)
  • mutL homolog 1 (E. coli) (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1)
  • 1110035C23Rik protein
  • AI317206 protein
  • AI325952 protein
  • AI561766 protein
  • CG11482 protein
  • COCA2 protein
  • Dmel\\CG11482 protein
  • dmlh-1 protein
  • dmlh1 protein
  • FCC2 protein
  • hMLH1 protein
  • HNPCC protein
  • HNPCC2 protein
  • LOC100232198 protein
  • MLH1 protein
  • zgc:66301 protein

Protein level used designations for MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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