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Browse our MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Proteins (MSH2)

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MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Proteins (MSH2)
On are 10 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Proteins from 2 different suppliers available. Additionally we are shipping MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Antibodies (5) and MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Kits (1) and many more products for this protein. A total of 18 MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) products are currently listed.
AI788990, ATMSH2, CG7895, COCA1, Dmel\CG7895, DmNK-4, DROHOXHK4, DROHOXNK4, FCC1, HNPCC, HNPCC1, HOX, LCFS2, msh-2, msh2, MUTS homolog 2, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, Tin, tin/NK4, wu:fc06b02, wu:fc13e09, zgc:55333
list all proteins Gene Name GeneID UniProt
Mouse MSH2 MSH2 17685 P43247
Rat MSH2 MSH2 81709 P54275
Human MSH2 MSH2 4436 P43246

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More Proteins for MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) Interaction Partners

Arabidopsis thaliana MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. The expression of AtMutSgamma (MSH7 and MSH2) in Saccharomyces cerevisiae suggest that AtMutSgamma affects yeast genomic stability by recognizing specific mismatches.

  2. The contribution of MutSalpha (MSH2-MSH6) to ultraviolet-induced DNA lesion repair and cell cycle regulation was investigated.

  3. reported that AtMSH2 has a broad range of anti-recombination effects: it suppresses recombination between divergent direct repeats in somatic cells or between homologues from different ecotypes during meiosis

Mouse (Murine) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Data show that in mutS homolog 2 protein Msh2(+/-) mice, azathioprine (Aza) induced a high incidence of microsatellite instability (MSI (show EBP Proteins)) lymphomas in a dose-dependent manner.

  2. In Msh2-/- mice, red meat enhanced survival compared to control (p<0.01) and lowered total tumour burden compared to resistant starch (p<0.167).

  3. Angptl2 (show ANGPTL2 Proteins)-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression.

  4. Gut (show GUSB Proteins) microbes did not induce colorectal cancer in APC (show APC Proteins)(Min/+)MSH2(-/-) mice through an inflammatory response or the production of DNA mutagens but rather by providing carbohydrate-derived metabolites such as butyrate that fuel hyperproliferation of MSH2(-/-) colon epithelial cells.

  5. MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in p53 (show TP53 Proteins)-deficient tumorigenesis.

  6. Results suggest that MSH2 is rate limiting for expansion in fragile X (show FMR1 Proteins) premutation mouse model and that MSH2 levels may be a key factor that accounts for tissue-specific differences in expansion risk.

  7. Toxicity, induced by tert (show TERT Proteins)-butyl-hydroperoxide and potassium bromate, differs in base excision repair proficient (Mpg (show MPG Proteins) (+/+), Nth1 (+/+)) and deficient (Mpg (show MPG Proteins) (-/-), Nth1 (-/-)) mouse embryonic fibroblasts following Msh2 knockdown, was examined.

  8. Medium-spiny striatal neurons-specific deletion of Msh2 was sufficient to eliminate the vast majority of striatal HTT (show HTT Proteins) CAG expansions in HTT (show HTT Proteins) CAG knock-in mice.

  9. Enhanced occupancy of Msh2 and Msh3 proteins is detected downstream of the FXN (show FXN Proteins) expanded GAA (show GAA Proteins) repeat, suggesting a model in which Msh2/3 dimers are recruited to this region to repair mismatches.

  10. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions

Zebrafish MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Identification and characterization of novel knockout mutants of the three major MMR (show MRC1 Proteins) genes, mlh1 (show MLH1 Proteins), msh2, and msh6 (show MSH6 Proteins), in zebrafish that develop tumors at low frequencies.

Human MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. A total of 201 unique disease-predisposing mismatch repair gene mutations were identified in 369 Lynch syndrome families. These mutations affected MLH1 (show MLH1 Proteins) in 40%, MSH2 in 36%, MSH6 (show MSH6 Proteins) in 18% and PMS2 (show PMS2 Proteins) in 6% of the families.

  2. There is a positive correlation between the expressions of hMSH2 and hMSH6 (show MSH6 Proteins) between males (RHO=0.673 and p=0.001) and females with colorectal adenocarcinoma.

  3. Individuals with Lynch syndrome and double-mutants in MSH6 (show MSH6 Proteins) and MSH2 had normal MSH2 expression, whereas MSH6 (show MSH6 Proteins) immunoexpression was lost in all evaluable cases.

  4. Loss of MLH1 (show MLH1 Proteins) expression was however observed in none of those including four Microsatellite instability + tumours . Expression of MSH2, another essential MMR (show MRC1 Proteins) gene, was also examined, but no alterations were found

  5. Upon stratifying the GEE model, reductions in ATM (show ATM Proteins) and MSH2 expression levels was heightened among women with an extended family history (FH) of breast cancer. Reduced expression of ATM (show ATM Proteins) and MSH2 compromises DNA repair capacity and, thereby, increases breast cancer prevalence.

  6. Alterations in p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins) expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 (show TP53 Proteins) and hMSH2 seem to be interrelated in early events of this process.

  7. screen was able to distinguish weak and strong pathogenic variants from polymorphisms and was used to investigate 59 Msh2 VUS. Nineteen of the 59 VUS were identified as pathogenic

  8. Report a family with an MSH2 mutation c.1126_1127delTT (p.Leu376Thrfs*12). A 46-year-old male proband developed keratoacanthoma, colon cancer and gastric cancer, and fulfilled the diagnostic criteria for Muir-Torre syndrome. His 80-year-old mother, diagnosed with hereditary non-polyposis colorectal cancer, presented with multiple gastrointestinal tract cancers, Bowen's disease and actinic keratosis.

  9. data supported an interdependence of mismatch repair proteins, particularly MLH1 (show MLH1 Proteins) and MSH2, in the mediation of apoptosis in human colorectal carcinoma cell lines

  10. In Lynch syndrome families, prostate cancer was associated with mutations in MSH2 with loss of the mismatch repair protein.

Fruit Fly (Drosophila melanogaster) MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) interaction partners

  1. Overexpression of Tinman and Pannier resulted in 20% of embryos with ectopic Hand and Sur (show ABCC8 Proteins) expression. By adding MEF2 (show MYEF2 Proteins) alongside Tinman and Pannier, an expansion in expression of Hand and Sur (show ABCC8 Proteins) was observed.

  2. Findings provide mechanistic insight into the brake on myogenesis that occurs during mesoderm specification: twist and tin expression at early stages in turn activate the myogenic inhibitor Him; yet, once Twist or Tin levels decline at mid-embryogenesis, Him is no longer expressed in the mesoderm, and MEF2 (show MYEF2 Proteins)-dependent muscle differentiation can proceed.

  3. Plasticity in Hox/PBC (show DLAT Proteins) interaction modes is a common molecular strategy for shaping Hox transcriptional activities.

  4. The enhancers active in the heart progenitor cells and the heart generally are dependent on tinman gene activity, whereas those active in non-cardiac mesoderm are often bound neutrally by Tinman

  5. Genetic interaction analysis shows that spir functionally interacts with Dorsocross, tin, and pannier to properly specify the cardiac fate.

  6. Tin is a direct regulator of midline in fly heart development.

  7. wg and dpp (show TGFb Proteins) contribute progressively to the elaboration of the expression pattern of the mesoderm-specific homeobox (show PRRX1 Proteins)-containing gene tinman (tin), and the overlap of wg and dpp (show TGFb Proteins) in the presence of tin-expressing cells directs cardiac-specific differentiation

  8. We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman, but does not require a differentiated visceral mesoderm.

  9. one of the major functions of mid and H15 during cardioblast development is the re-activation of tin expression at a stage when the induction of tin by Dpp (show TGFb Proteins) in the dorsal mesoderm has ceased

  10. dSUR is regulated by tinman and plays a protective role against hypoxic stress and pacing-induced heart failure

MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2) Protein Profile

Protein Summary

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. Coli) (MSH2)

  • mismatch repair protein (MSH2)
  • DNA mismatch repair protein Msh2 (MSH2)
  • mutS homolog 2 (E. coli) (Msh2)
  • mutS homolog 2 (E. coli) (msh2)
  • mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2)
  • tinman (tin)
  • AI788990 protein
  • ATMSH2 protein
  • CG7895 protein
  • COCA1 protein
  • Dmel\CG7895 protein
  • DmNK-4 protein
  • DROHOXHK4 protein
  • DROHOXNK4 protein
  • FCC1 protein
  • HNPCC protein
  • HNPCC1 protein
  • HOX protein
  • LCFS2 protein
  • msh-2 protein
  • msh2 protein
  • MUTS homolog 2 protein
  • NK-4 protein
  • NK-4/msh-2 protein
  • NK4 protein
  • NK4/msh-2 protein
  • NKX2.5 protein
  • Tin protein
  • tin/NK4 protein
  • wu:fc06b02 protein
  • wu:fc13e09 protein
  • zgc:55333 protein

Protein level used designations for MSH2

mismatch repair protein , DNA mismatch repair protein Msh2 , mutS protein homolog 2 , mismatch repair protein Msh2 , hMSH2 , mutS-like protein 2 , MutS-like protein 2 , CG7895-PA , muscle-specific-homeodomain-2 , tin-PA

100268052 Vitis vinifera
821383 Arabidopsis thaliana
17685 Mus musculus
81709 Rattus norvegicus
406845 Danio rerio
4436 Homo sapiens
378799 Gallus gallus
494002 Canis lupus familiaris
100337661 Sus scrofa
533115 Bos taurus
42536 Drosophila melanogaster
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