Browse our NEIL2 Proteins (NEIL2)

Full name:
Nei Endonuclease VIII-Like 2 (E. Coli) Proteins (NEIL2)
On are 8 Nei Endonuclease VIII-Like 2 (E. Coli) (NEIL2) Proteins from 5 different suppliers available. Additionally we are shipping NEIL2 Antibodies (43) and many more products for this protein. A total of 59 NEIL2 products are currently listed.
Gm1212, NEH2, NEI2
list all proteins Gene Name GeneID UniProt
NEIL2 252969 Q969S2
NEIL2 382913  

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NEIL2 Proteins (NEIL2) by Origin

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Top referenced NEIL2 Proteins

  1. Human NEIL2 Protein expressed in Escherichia coli (E. coli) - ABIN1098272 : Das, Chattopadhyay, Bhakat, Boldogh, Kohno, Prasad, Wilson, Hazra: Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for 1098272

More Proteins for NEIL2 Interaction Partners

Human Nei Endonuclease VIII-Like 2 (E. Coli) (NEIL2) interaction partners

  1. The abnormal expressions of NEIL1 (show NEIL1 Proteins), NEIL2, and NEIL3 (show NEIL3 Proteins) are involved in cancer through their association with the somatic mutation load.

  2. NEIL1 (show NEIL1 Proteins) and NEIL2 cooperate with TDG (show TDG Proteins) during base excision: TDG (show TDG Proteins) occupies the abasic site and is displaced by NEILs, which further process the baseless sugar, thereby stimulating TDG (show TDG Proteins)-substrate turnover.

  3. Studied six SNP loci: (rs2279115 of BCL2 (show BCL2 Proteins) gene, rs804270 of NEIL2 gene, rs909253 of LTA (show LTA Proteins) gene, rs2294008 of PSCA (show PSCA Proteins) gene, rs3765524 and rs10509670 of PLCE1 (show PLCE1 Proteins) gene) to evaluate gastric cancer risk using magnetic nanoparticles and universal tagged arrays.

  4. The variability of potentially important functional polymorphic variants of the IFNG (show IFNG Proteins), IFNGR2 (show IFNGR2 Proteins) and NEIL2 genes was characterized in representatives of four ethnic groups living in the Siberian region.

  5. variant alleles in the NEIL2 (rs804270), APE1 (show APEX1 Proteins) (rs2275008), CYP2E1 (show CYP2E1 Proteins) (rs2031920) and MDM2 (show MDM2 Proteins) (rs2279744) SNPs may independently influence susceptibility to gastric cancer in a Northern Jiangsu Chinese population.

  6. data strongly suggest that decreased repair of oxidative DNA base lesions due to an impaired NEIL2 expression in non-smokers exposed to SSS would lead to accumulation of mutations in genomic DNA of lung cells over time

  7. CSB (show ERCC6 Proteins) protein stimulates NEIL2 DNA glycosylase activity

  8. Results suggest that the decreased DNA repair capacity of the DNA glycosylase NEIL2 R257L variant can induce mutations that lead to lung cancer development.

  9. the critical role of NEIL2 and PNKP (show PNKP Proteins) in maintenance of the mammalian mitochondrial genome.

  10. REG4 (show REG4 Proteins), BIRC5 (show BIRC5 Proteins) and NEIL2 genes might have a role in the sensitivity of cancer patients to radiotherapy

Mouse (Murine) Nei Endonuclease VIII-Like 2 (E. Coli) (NEIL2) interaction partners

  1. NEIL2 plays an important role in long term genomic maintenance

  2. the beta2/beta3 loop where Lys50 is located in NEIL2 is important for DNA binding, presumably lies next to a phosphate-binding site, and may represent a target for regulation of the enzyme activity.

  3. NEIL1 (show NEIL1 Proteins) and NEIL2 are essential in the recognition of oxidized lesions arising from 8-oxoG and may play important roles in the repair of DNA damage induced by carcinogenic metals.

  4. Recombinant human DNA Polymerase beta (show POLB Proteins) and recombinant mpise NEIL2 associated with microtubules in situ and in vivo.

  5. Keap1 (show KEAP1 Proteins) recruits NEH2 through binding to ETGE and DLG (show DLG4 Proteins) motifs.

  6. Results suggest a role for NEIL1 (show NEIL1 Proteins) and 2 as backup deoxyribo-5'-phosphate lyases in mammalian cells.

NEIL2 Protein Profile

Protein Summary

NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002

Alternative names and synonyms associated with NEIL2

  • nei endonuclease VIII-like 2 (E. coli) (NEIL2)
  • nei like 2 (E. coli) (Neil2)
  • Gm1212 protein
  • NEH2 protein
  • NEI2 protein

Protein level used designations for NEIL2

DNA glycosylase/AP lyase Neil2 , DNA-(apurinic or apyrimidinic site) lyase Neil2 , endonuclease 8-like 2 , endonuclease VIII-like 2 , nei homolog 2 , nei like 2 , nei-like protein 2 , NEH2 , Endonuclease VIII-like 2

252969 Homo sapiens
444987 Bos taurus
100172638 Pongo abelii
382913 Mus musculus
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