Browse our POLB (POLB) ELISA Kits

On are 5 Polymerase (DNA Directed), beta (POLB) ELISA Kits from 5 different suppliers available. Additionally we are shipping POLB Antibodies (105) and POLB Proteins (14) and many more products for this protein. A total of 132 POLB products are currently listed.
A430088C08Rik, DDBDRAFT_0186152, DDBDRAFT_0215784, DDBDRAFT_0232376, DDB_0186152, DDB_0215784, DDB_0232376, POLB, wu:fa97a05, zgc:109924
list all ELISA KIts Gene Name GeneID UniProt
POLB 5423 P06746
POLB 18970 Q8K409
POLB 29240 P06766

POLB (POLB) ELISA Kits by Reactivity

More ELISA Kits for POLB Interaction Partners

Zebrafish Polymerase (DNA Directed), beta (POLB) interaction partners

  1. DNA polymerase beta is sensitive to Mn2+ and Mg2 (show MCOLN1 ELISA Kits)+ and its optimumal pH is 9.

  2. In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.

Human Polymerase (DNA Directed), beta (POLB) interaction partners

  1. Data suggest that POLB activity is not essential for HIV-1 integration into human macrophages and other cells; limited cellular dNTP pools, but not POLB expression, are primary factor for HIV-1 DNA gap repair, particularly in non-dividing cells.

  2. High DNA polymerase beta mRNA expression is associated with Graves' thyroid tissue.

  3. Polbeta was shown to inhibit the 3'->5' exonuclease activity of APE1 (show APEX1 ELISA Kits) when both enzymes were added simultaneously and to insert the correct nucleotide into the gap arising after hydrolysis of AP site clustered with the benzo[a]pyrene adducts.

  4. Remote mutations induce functional changes in active site residues of human DNA polymerase beta.

  5. It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (show ASIP ELISA Kits) 256.

  6. The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).

  7. HMGB1 (show HMGB1 ELISA Kits) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.

  8. The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.

  9. PolB is ubiquitylated on amino-acid residues K206 and K244 when not in a complex with XRCC1 (show XRCC1 ELISA Kits).

  10. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

Mouse (Murine) Polymerase (DNA Directed), beta (POLB) interaction partners

  1. pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.

  2. we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues

  3. The aberrant DNA replication mediated by the PCNA (show PCNA ELISA Kits)-DNA pol-b complex induces p53 (show TP53 ELISA Kits)-dependent neuronal cell death

  4. Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.

  5. Pol beta deficiency could enable ROS (show ROS1 ELISA Kits) accumulation.

  6. Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 ELISA Kits)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 ELISA Kits).

  7. Transient OGG1 (show OGG1 ELISA Kits), APE1 (show APEX1 ELISA Kits), PARP1 (show PARP1 ELISA Kits) and Polbeta expression in an Alzheimer's disease mouse model.

  8. Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 ELISA Kits) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (show MBD3 ELISA Kits) in individual morula embryos.

  9. Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.

  10. Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (show ROS1 ELISA Kits) level and depolarization of mitochondria.

POLB Antigen Profile

Antigen Summary

The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.

Alternative names and synonyms associated with POLB

  • polymerase (DNA directed), beta (polb) Elisa Kit
  • polymerase (DNA directed), beta (POLB) Elisa Kit
  • DNA polymerase X family protein (polB) Elisa Kit
  • DNA polymerase beta-like (LOC100526021) Elisa Kit
  • polymerase (DNA directed), beta (Polb) Elisa Kit
  • A430088C08Rik Elisa Kit
  • DDBDRAFT_0186152 Elisa Kit
  • DDBDRAFT_0215784 Elisa Kit
  • DDBDRAFT_0232376 Elisa Kit
  • DDB_0186152 Elisa Kit
  • DDB_0215784 Elisa Kit
  • DDB_0232376 Elisa Kit
  • POLB Elisa Kit
  • wu:fa97a05 Elisa Kit
  • zgc:109924 Elisa Kit

Protein level used designations for POLB

DNA-directed DNA polymerase beta , DNA polymerase beta , polymerase (DNA directed), beta , DNA polymerase beta-like , DNA pol beta , DNA polymerase beta subunit , mutant DNA polymerase beta , Pol beta , polymerase-beta

448741 Xenopus (Silurana) tropicalis
554204 Danio rerio
704801 Macaca mulatta
737210 Pan troglodytes
8624738 Dictyostelium discoideum AX4
100348691 Oryctolagus cuniculus
100393825 Callithrix jacchus
100441812 Pongo abelii
100526021 Sus scrofa
5423 Homo sapiens
614688 Bos taurus
397973 Xenopus laevis
18970 Mus musculus
29240 Rattus norvegicus
426794 Gallus gallus
494001 Canis lupus familiaris
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