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Human POLB ELISA Kit for Sandwich ELISA - ABIN421299
Li, Li, Yu, Zhang, Wang, Jia: miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium. in Toxicology letters 2014
DNA polymerase beta is sensitive to Mn2+ and Mg2 (show MCOLN1 ELISA Kits)+ and its optimumal pH is 9.
In brief, the major differences in BER performed by early stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicative polymerases, in early stage embryos.
Remote mutations induce functional changes in active site residues of human DNA polymerase beta.
It has been concluded based on calculations and the experimental pH profile that the most likely path for the wild-type (WT) and the D256E and D256A mutants is a proton transfer (PT) to the bulk, although the WT may also use a PT to Asp (show ASIP ELISA Kits) 256.
The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002).
HMGB1 (show HMGB1 ELISA Kits) stimulates activity of DNA polymerase beta on nucleosome substrates in the process of base excision repair.
The results help to define the tolerance of DNA Pol beta to subtle local structural and functional alterations derived from lysine 72.
HSP90 (show HSP90 ELISA Kits) regulates DNA repair by interaction between XRCC1 (show XRCC1 ELISA Kits) and DNA polymerase beta.
Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.
a substitution mutation, R152C, impairs Pol beta polymerase activity and DNA base excision repair efficiency.
Data show that esophageal carcinoma (EC) cells expressing the DNA polymerase beta K167I variant to be sensitive to DNA damaging agents.
Pol lambda (show POLL ELISA Kits) can incorporate rNMPs opposite normal bases or 8-oxo-G, and with a different fidelity. Further, the incorporation of rNMPs opposite 8-oxo-G delays repair by DNA glycosylases.
pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair.
we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues
The aberrant DNA replication mediated by the PCNA (show PCNA ELISA Kits)-DNA pol-b complex induces p53 (show TP53 ELISA Kits)-dependent neuronal cell death
Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells.
Pol beta deficiency could enable ROS (show ROS1 ELISA Kits) accumulation.
Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM (show CNTNAP1 ELISA Kits)) with no effect on mutation specificity, suggesting no direct role in SHM (show CNTNAP1 ELISA Kits).
Transient OGG1 (show OGG1 ELISA Kits), APE1 (show APEX1 ELISA Kits), PARP1 (show PARP1 ELISA Kits) and Polbeta expression in an Alzheimer's disease mouse model.
Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 (show APEX1 ELISA Kits) and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 (show MBD3 ELISA Kits) in individual morula embryos.
Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity.
Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS (show ROS1 ELISA Kits) level and depolarization of mitochondria.
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date.
DNA-directed DNA polymerase beta
, DNA polymerase beta
, polymerase (DNA directed), beta
, DNA polymerase beta-like
, DNA pol beta
, DNA polymerase beta subunit
, mutant DNA polymerase beta
, Pol beta