Browse our XPA Proteins (XPA)

Full name:
Xeroderma Pigmentosum, Complementation Group A Proteins (XPA)
On are 6 Xeroderma Pigmentosum, Complementation Group A (XPA) Proteins from 4 different suppliers available. Additionally we are shipping XPA Antibodies (139) and XPA Kits (3) and many more products for this protein. A total of 160 XPA products are currently listed.
AI573865, CG6358, DhR14, DhXPA, Dmel\\CG6358, dmXPA, dxpa, EG:EG0007.8, XP1, Xpa, xpac, XPA_DROME, xxpa
list all proteins Gene Name GeneID UniProt
XPA 7507 P23025
Mouse XPA XPA 22590 Q64267
Rat XPA XPA 298074  

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XPA Proteins (XPA) by Origin

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Top referenced XPA Proteins

  1. Human XPA Protein expressed in Escherichia coli (E. coli) - ABIN1098757 : Pan, Lee: UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity. in Cell cycle (Georgetown, Tex.) 2009 (PubMed)

More Proteins for XPA Interaction Partners

Human Xeroderma Pigmentosum, Complementation Group A (XPA) interaction partners

  1. These results illustrate that EZH2 (show EZH2 Proteins) may promote carcinogenesis and cancer development of nasopharyngeal carcinoma by transcriptional repression of XPA gene and inactivation of nucleotide excision repair pathway.

  2. SNP rs10817938 in promoter region associated with poor prognosis of oral squamous cell carcinoma in Chinese Han population

  3. We showed that loss of HERC2 function leads to the accumulation of XPA and BRCA1 in the patient's fibroblasts and generates decreased sensitivity to apoptosis and increased level of DNA repair

  4. Accumulating evidence suggests that XPA and the helicase activity of transcription factor IIH (TFIIH (show GTF2H1 Proteins)) cooperate to verify abnormalities in damaged DNA chemistry. (Review)

  5. XPA is a key scaffold protein (show HOMER1 Proteins) for human nucleotide excision repair. (Review)

  6. XPA reduction increased cell viability of a bladder cancer cell line RT4, while XPA re-expression decreased the cell viability of RT4 cells. Study suggests that downregulated XPA may promote carcinogenesis of bladder cancer via impairment of DNA repair.

  7. The risk of esophageal squamous cell carcinoma associated with XPA rs-1800975 was determined. A high ESCC risk was found in subjects who carried the homozygous minor allele of XPA, especially in smokers, those in adobe houses, drinkers of salt tea, or those with a family history of cancer. Variant genotypes of both XPA and XPC (show XPC Proteins) in combination showed an increased risk towards ESCC.

  8. The role of conformational selection in the molecular recognition of the wild type and mutants XPA67-80 peptides by ERCC1 (show ERCC1 Proteins) has been described.

  9. We discovered four new XP-A patients and a novel XPA mutation resulting in two diverse patient alleles.

  10. a specific XPA genotype is associated with mild phenotype in Xeroderma Pigmentosum in United Kingdom immigrants from India, Pakistan, and Afghanistan

Mouse (Murine) Xeroderma Pigmentosum, Complementation Group A (XPA) interaction partners

  1. The authors' results suggest that lack of the DNA repair factor XPA may delay neurobehavioral recovery after TBI (show TBPL1 PLURAL_@42429@)

  2. Oxidized glycerophosphocholines play a pivotal role in the photosensitivity associated with the deficiency of XPA.

  3. The tissue-specific effect of Xpa deficiency represents a novel finding; it suggests that tissue-to-tissue variation in CAG repeat (show CELF3 Proteins) instability arises, in part, by different underlying mechanisms.

  4. The circadian oscillation of XPA is achieved both by regulation of transcription by the core circadian clock proteins including cryptochrome and by regulation at the posttranslational level by the HERC2 ubiquitin ligase.

  5. The Xpa/p53 (show TP53 Proteins)+/- mouse model is an excellent candidate for a future replacement of the chronic mouse bioassay for certain classes of chemicals.

  6. Xeroderma pigmentosum group A (XPA) gene-deficient mice cannot repair UV-induced DNA damage and easily develop skin cancers by UV irradiation. UVB-induced local and systemic immunosuppression was greatly enhanced in the (-/-) mice.

  7. Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice

  8. XPA (-/-), SCF (show KITLG Proteins)-Tg mice did not develop skin cancers after repeated exposures to UVB for 30 wk at a total dose of 72 J per cm(2)

  9. Xpa-/- keratinocytes (complete nucleotide excision repair deficiency) show a rapid depletion of DNA replicating S-phase cells, a transient increase in quiescent S-phase cells (not replicating DNA), followed by massive apoptosis.

  10. The human carcinogen phenacetin acts as a weak genotoxic agent in an in vivo mouse model system in an Xpa deficient model.

XPA Protein Profile

Protein Summary

This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with XPA

  • Xeroderma pigmentosum group A-like (Xpac)
  • xeroderma pigmentosum, complementation group A (XPA)
  • xeroderma pigmentosum, complementation group A (Xpa)
  • xeroderma pigmentosum, complementation group A (xpa)
  • AI573865 protein
  • CG6358 protein
  • DhR14 protein
  • DhXPA protein
  • Dmel\\CG6358 protein
  • dmXPA protein
  • dxpa protein
  • EG:EG0007.8 protein
  • XP1 protein
  • Xpa protein
  • xpac protein
  • XPA_DROME protein
  • xxpa protein

Protein level used designations for XPA

CG6358-PA , Xpac-PA , xeroderma pigmentosum group A-like , DNA repair protein complementing XP-A cells , excision repair-controlling , xeroderma pigmentosum group A-complementing protein , DNA repair protein complementing XP-A cells homolog , xeroderma pigmentosum group A-complementing protein homolog , xpacch protein , xpacx1 protein

31357 Drosophila melanogaster
7507 Homo sapiens
22590 Mus musculus
395659 Gallus gallus
298074 Rattus norvegicus
397790 Xenopus laevis
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