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anti-Human XRCC1 Antibodies:
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Human Polyclonal XRCC1 Primary Antibody for ICC, IF - ABIN151964
Iles, Rulten, El-Khamisy, Caldecott: APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks. in Molecular and cellular biology 2007
Show all 3 Pubmed References
Study suggested that RAD51 (show RAD51 Antibodies), XRCC1, and XRCC3 (show XRCC3 Antibodies) polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
Allelic variants in ERCC1 and ERCC2 are not associated with an increased risk of developing pre-senile cataract. The presence of Gln/Gln in XRCC1 in the pre-senile cataract group with regard to the group without cataract is associated with a major risk of developing pre-senile cataract.
XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
XRCC1 polymorphism is associated with colorectal cancer.
We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2 (show BRCA2 Antibodies)], rs1805389 [ LIG4 (show LIG4 Antibodies)], rs8079544 [ TP53 (show TP53 Antibodies)], rs25489 [ XRCC1], rs1673041 [ POLD1 (show POLD1 Antibodies)], and rs11615 [ ERCC1 (show ERCC1 Antibodies)]) and subsequent CNS tumors in survivors of childhood cancer treated by radiation therapy.
our study provided preliminary evidence that the ERCC2 (show ERCC2 Antibodies) rs50872 T allele was associated with a favorable survival while the XRCC1 rs25487 A allele was associated with a worse survival outcome for advanced NSCLC patients.
Study confirmed an association between XRCC1 codon 399 genotype and the risk of acute radiation dermatitis in locally advanced nasopharyngeal carcinoma patients during intensity-modulated radiation therapy.
This study demonstrates that the presence of His allele and Gln allele in case of SULT1A1 (show SULT1A1 Antibodies) rs9282861 and XRCC1 rs25487, respectively, involve in lung cancer prognosis in Bangladeshi population.
XRCC1 Arg399Gln variant might not be risk alleles for breast cancer susceptibility in the Chinese population (Meta-Analysis)
XRCC1 and PNKP (show PNKP Antibodies) interact via a high-affinity phosphorylation-dependent interaction site in XRCC1 and a forkhead-associated domain in PNKP (show PNKP Antibodies). Data suggest a second PNKP (show PNKP Antibodies) interaction site in XRCC1 that binds PNKP (show PNKP Antibodies) with lower affinity and independently of XRCC1 phosphorylation. (XRCC1 = X-ray repair cross complementing protein 1; PNKP (show PNKP Antibodies) = polynucleotide kinase 3'-phosphatase (show PNKP Antibodies))
data establish the importance of XRCC1 protein complexes for normal neurological function and identify PARP1 (show PARP1 Antibodies) as a therapeutic target in DNA strand break repair-defective disease
We have characterized the nuclear localization signal (NLS (show ALDH1A2 Antibodies)) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging.
Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Antibodies), Neil1 (show NEIL1 Antibodies), Mutyh (show MUTYH Antibodies) and Xrcc1 in the brain of adult offspring.
In cells with DNA base damage, PAR (show AFG3L2 Antibodies) serves to recruit XRCC1 that in turn binds and recruits pol beta (show POLB Antibodies), the primary DNA polymerase (show POLB Antibodies) of the base excision repair pathway.
Lig4 (show LIG4 Antibodies) and XRCC1 double-deficient cells switch as efficiently as Lig4 (show LIG4 Antibodies)-deficient cells, clearly indicating that XRCC1 is dispensable for A-EJ in CH12F3 cells during class switch recombination
findings firmly demonstrate that XRCC1 is not a requisite factor for A-EJ of chromosomal DSBs and raise the possibility that DNA ligase 1 (Lig1 (show LIG1 Antibodies)) may contribute more to A-EJ than previously considered
Data support a role for XRCC1 in microhomology-mediated joining, and imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.
Results indicates that XRCC1 haploinsufficiency has little effect on chronological longevity and many key biological markers of aging, but may adversely affect normal animal development or increase disease susceptibility to a relevant genotoxic exposure.
data reveal that the critical biological role of Lig3 (show LIG3 Antibodies) is to maintain mtDNA integrity and not Xrcc1-dependent DNA repair
results establish a role for Lig3 (show LIG3 Antibodies) in mitochondria, but distinguish it from its interacting protein Xrcc1
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
X-ray repair complementing defective repair in Chinese hamster cells 1
, X-ray repair cross complementing protein 1
, DNA repair protein XRCC1-like
, DNA repair protein XRCC1
, X-ray repair cross-complementing protein 1
, X-ray-repair, complementing defective, repair in Chinese hamster
, x-ray repair cross-complementing group 1 protein