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These results establish maternal Asc1l as a key factor in establishing pre-patterning of the early embryo, acting in opposition to VegT and biasing the animal pole to adopt neural fates.
analysis of cell-cycle-dependent phosphorylation of the key reprogramming transcription factor Ascl1 on multiple serine-proline sites
Epigenetic regulators play vital roles in cancer pathogenesis and represent a new frontier in therapeutic targeting. Our studies provide basic mechanistic insight into the role of H3K36me2 in transcription activation and MLL (show MLL Proteins) leukemia pathogenesis and implicate ASH1L (show ASH1L Proteins) histone methyltransferase as a promising target for novel molecular therapy.
Results indicate transcription factor Ascl1 protein functionalized with intracellular protein (show CKAP2 Proteins) delivery technology (Ascl1-IPTD) as a powerful tool for engineering neural tissue from pluripotent stem cells.
knocking down achaete-scute complex homologue-1 expression could significantly suppress the proliferation, migration, and invasion of laryngeal carcinoma cell in vitro and disorder epithelial-mesenchymal transformation-associated protein expression.
we found that CpG_6.7.8 of the achaete-scute homolog 1 CpG island is frequently hypermethylated in early-stage pulmonary neuroendocrine tumors, and this aberrant hypermethylation is negatively correlated with achaete-scute homolog 1 expression in this tumor spectrum
Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta-thalassaemia severity.
the first comprehensive high-resolution information on the structural propensities and conformational dynamics of Ascl1, is reported.
ASCL1 expression may determine the cell behaviors of SCLC partly through modifying EMT (show ITK Proteins) phenotypes.
This report identifies novel roles (show DDC Proteins)for the transcription factor Ascl1 in enteric gliogenesis and neurogenesis
ASCL1 expression is regulated by BRD4 (show BRD4 Proteins) is frequently overexpressed in small cell lung cancer.
Data show that chrysin suppressed cell proliferation and reducing expression of achaete-scute complex-like 1 (ASCL1) and the neuroendocrine biomarker chromogranin A (CgA (show CHGA Proteins)).
ASCL1 and NEUROD1 distinguish heterogeneity in SCLC with distinct genomic landscapes.
Results are the first to define the timing of gliogenesis in the tuberal hypothalamus and indicate that Ascl1 is required to repress oligodendrocyte differentiation within this brain region.
This study showed that the combination of the microRNAs miR (show MLXIP Proteins)-124-9-9* with the transcription factor Ascl1 significantly increase neuronal reprogramming of Muller glia.
The chemical compound forskolin combined with Ascl1 induced approximately 80% of mouse fibroblasts to iPV neurons.
we observe that the early-born 5-HT (show DDC Proteins)(+) neurons are generated in Ascl1(-/-) mutants
the combination of gain- and loss-of-function experiments in the developing midbrain showed co-operative roles for Mgn (show HELT Proteins) and Mash1 genes in determining GABAergic identity.
This study findings demonstrate that Ascl1(CreERT2) and Glast (show SLC1A3 Proteins)(CreERT2) mouse lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows.
results show that at least one of the differences between mammal and fish Muller glia that bears on their difference in regenerative potential is the proneural transcription factor Ascl1
This suggests that the maintenance of ASCL1 in its multiply phosphorylated state might prevent terminal differentiation in neuroblastoma (show ARHGEF16 Proteins).
CPAP (show CENPJ Proteins) regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1.
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.
achaete-scute complex homolog 1 (Drosophila)
, achaete-scute complex-like 1
, achaete-scute homolog 1
, achaete scute protein
, class A basic helix-loop-helix protein 46
, achaete-scute complex homolog-like 1
, mammalian achaete scute homolog 1
, achaete-scute complex homolog 1
, achaete-scute homolog 2
, transcription factor cash4
, ASH1-like protein
, absent small and homeotic disks protein 1 homolog
, histone-lysine N-methyltransferase ASH1L
, lysine N-methyltransferase 2H
, probable histone-lysine N-methyltransferase ASH1L