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Browse our SOX2 Proteins (SOX2)

Full name:
SRY (Sex Determining Region Y)-Box 2 Proteins (SOX2)
On are 37 SRY (Sex Determining Region Y)-Box 2 (SOX2) Proteins from 14 different suppliers available. Additionally we are shipping SOX2 Antibodies (449) and SOX2 Kits (11) and many more products for this protein. A total of 512 SOX2 products are currently listed.
anop3, cb236, lcc, mcops3, Qscn6, Qsox, RGD1565646, rSOx, sox-2, SRY-box2, wu:fb83g04, wu:fc14d07, Xsox-2, ysb, zgc:65860, zgc:77389
list all proteins Gene Name GeneID UniProt
Rat SOX2 SOX2 84491 Q6IUU3
SOX2 6657 P48431
SOX2 20674 P48432

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SOX2 Proteins (SOX2) by Origin

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Top referenced SOX2 Proteins

  1. Human SOX2 Protein expressed in Escherichia coli (E. coli) - ABIN666968 : Wei, Yang, Zhang, Andrianakos, Hasegawa, Lyu, Chen, Bai, Liu, Pera, Lu: Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. in Stem cells (Dayton, Ohio) 2010 (PubMed)
    Show all 2 references for ABIN666968

More Proteins for SOX2 Interaction Partners

Human SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Oct4 (show POU5F1 Proteins)+Sox2+ cells may be reprogrammed cancer stem cells inducing oral carcinogenesis.

  2. At the subcellular level, SOX2 inhibited the GC cell migration and invasion by upregulating p21 (show CDKN1A Proteins) expression. Moreover, SOX2 was determined to associate with the nuclear p21 (show CDKN1A Proteins) expression. GC patients with high SOX2 and nuclear p21 (show CDKN1A Proteins) expression had synergistically less lymph node metastasis and the better overall survival

  3. SOX2 expression correlates with gastric and intestinal differentiation in Barrett's esophagus towards adenocarcinoma.

  4. Luteolin and apigenin activated expression of Oct-4 (show POU5F1 Proteins), Sox2, and c-Myc (show MYC Proteins) in a time- and dose-dependent pattern, and repressed lineage-specific differentiation. Blocking of the NFATc1 (show NFATC1 Proteins) signal with INCA (show CARD17 Proteins)-6 significantly decreased mRNA and protein expression of Oct-4 (show POU5F1 Proteins), Sox2, and c-Myc (show MYC Proteins) in periodontal ligament cells with luteolin/apigenin treatment

  5. we showed that ectopic expression of Sox2 in A549 cells was sufficient to render them more resistant to rapamycin treatment in vitro. These data suggested that rapamycin inhibited the function of lung cancer stem cells via SOX2.

  6. We propose that the finding of SOX2 overexpression in FTE could be exploited to develop biomarkers for detecting disease at a premalignant stage, which would reduce mortality from this devastating disease.

  7. Data show that cancer stem cell (CSC) properties in prostate cancer (PrCa) cells were induced by transducing OCT3/4 (show POU5F1 Proteins), SOX2, and KLF4 (show KLF4 Proteins) genes.

  8. Expression of miR (show MLXIP Proteins)-450b-5p was negatively correlated to the expression of SOX2

  9. Sox2-positive cells were found in the respective primary tumors.

  10. lncRNA-ROR effectively maintains Sox2 gene expression through competitive binding to miR (show MLXIP Proteins)-145.

Xenopus laevis SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.

  3. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  4. Suggest that SOX2 directly upregulates FGF8 (show FGF8 Proteins) gene expression in the early embryonic development of Xenopus.

  5. Continuous expression of Sox1 (show SOX1 Proteins) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.

  6. direct interaction and interdependence between the Otx2 (show OTX2 Proteins) and Sox2 proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.

  7. Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2

  8. A directional Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 has a role in pluripotency in pig embryos

  2. Overexpression of Sox2 or Oct4 (show POU5F1 Proteins) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.

  3. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level

Cow (Bovine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Proteins).

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Sox2 displayed relatively the same methylation levels between sperm and oocytes

Mouse (Murine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 (show ATOH1 Proteins) expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1 (show ATOH1 Proteins).

  2. Data show that the reprogramming factors OCT4 (show POU5F1 Proteins), SOX2, KLF4 (show KLF4 Proteins), and MYC (show MYC Proteins) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  3. SOX2 is a regulatory factor of Prop1 (show PROP1 Proteins) expression

  4. our study provides valuable information on the molecular interactions between OSKM(Oct4 (show POU5F1 Proteins), Sox2, Klf4 (show KLF4 Proteins), and Myc (show MYC Proteins)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 Proteins) and early development

  5. These findings show that SOX2 activity is modulated by O-acetylglusosamine, and provide a novel regulatory mechanism for this crucial pluripotency transcription factor.

  6. Besides its role in fine-tuning the precise level of Sox2, Ube2s (show UBE2S Proteins) reinforces the self-renewing and pluripotent state of embryonic stem cells.

  7. SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period.

  8. Using photo-activatable Fluorescence Correlation Spectroscopy to quantify transcription factor-DNA binding in single cells of developing mouse embryos, study found that Sox2 long-lived binding varies between blastomeres and is regulated by H3R26 methylation.

  9. Our findings clarify that mutated SOX2-positive SCs (show TWIST1 Proteins) can underlie the pathogenesis of odontoma, through a mechanism of induction similar to embryonic odontogenesis.

  10. The REST-miR (show MLXIP Proteins)-21-Sox2 axis connects REST to the core nuclear pluripotency regulators in E14Tg2a.4 mESCs cultured in the absence of feeder cells.

Zebrafish SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.

  2. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury

  3. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.

  4. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.

  5. Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2/3/19a/19b resulted in severe developmental abnormalities.

  6. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration

  7. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs

  8. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line

  9. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.

SOX2 Protein Profile

Protein Summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Alternative names and synonyms associated with SOX2

  • SRY (sex determining region Y)-box 2 (LOC100231711)
  • quiescin Q6 sulfhydryl oxidase 1 (Qsox1)
  • SRY (sex determining region Y)-box 2 (SOX2)
  • SRY (sex determining region Y)-box 2 (Sox2)
  • SRY (sex determining region Y)-box 2 (sox2)
  • SRY-box containing gene 2 (Sox2)
  • SRY-box containing gene 2 (sox2)
  • anop3 protein
  • cb236 protein
  • lcc protein
  • mcops3 protein
  • Qscn6 protein
  • Qsox protein
  • RGD1565646 protein
  • rSOx protein
  • sox-2 protein
  • SRY-box2 protein
  • wu:fb83g04 protein
  • wu:fc14d07 protein
  • Xsox-2 protein
  • ysb protein
  • zgc:65860 protein
  • zgc:77389 protein

Protein level used designations for SOX2

SRY (sex determining region Y)-box 2 , FAD-dependent sulfhydryl oxidase-2 , rQSOX , sulfhydryl oxidase 1 , SRY-related HMG-box gene 2 , transcription factor SOX-2 , transcription factor SOX2 , SRY-box containing gene 2 , Sox2 transcription factor , cSox2 , delta EF2a , XSox2 , XlSOX-2 , sex-determining region Y-box 2 , transcription factor Sox-2 , SRY-box 2 , SRY-related HMG-box 2 , sex determining region Y-box 2 , soxp

100231711 Taeniopygia guttata
84491 Rattus norvegicus
6657 Homo sapiens
499593 Rattus norvegicus
396105 Gallus gallus
488092 Canis lupus familiaris
398000 Xenopus laevis
407739 Sus scrofa
784383 Bos taurus
101110563 Ovis aries
707039 Macaca mulatta
460869 Pan troglodytes
100379629 Felis catus
100714747 Cavia porcellus
20674 Mus musculus
378723 Danio rerio
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