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Human SOX2 Protein expressed in HEK-293 Cells - ABIN2732450
Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. in Cell 2015
Results show that BPA (show DST Proteins) induced SOX2 mRNA and protein in MCF-7 mammospheres, resulting from enhanced CREB (show CREB1 Proteins) phosphorylation, and subsequent binding of pCREB to a SOX2 downstream enhancer. Also, BPA (show DST Proteins) activation of SOX2 seems to enhance cancer stem-like cell activity which contributes to breast cancer tumor maintenance.
In our three patients and four further, reported "genotype first" SOX2 microdeletion patients, anophthalmia/microphthalmia was present in less than half of the patients. Thus, SOX2 is another example of a gene whose clinical spectrum is broadened by the generation of "genotype first" findings using hypothesis-free, genome-wide methods.
These data suggest that elevated expression of SOX2 can activate lncRNA PVT1 expression promoted breast cancer tumorigenesis and progression. PVT1 may be a prognostic predictive biomarker for breast cancer, and the interaction of PVT1-SOX2 could be a therapeutic target in breast cancer.
In addition to its angiogenic action, VEGFA (show VEGFA Proteins) upregulates Sox2 to drive stem cell expansion, together with miR (show MLXIP Proteins)-452 loss and Slug (show SNAI2 Proteins) upregulation, providing a novel mechanism whereby cancer stem cells acquire metastatic potential.
SOX2 expression induces a cellular stem cell state in human colorectal cancer with a decreased expression of CDX2 (show CDX2 Proteins).
FOXG1 (show FOXG1 Proteins) and SOX2 operate in complementary but distinct roles to fuel unconstrained self-renewal in Glioblastoma multiforme stem cells via transcriptional control of core cell cycle and epigenetic regulators.
Sox2 plays an essential role in melanocyte transformation and melanoma growth.
The lack of a tumorigenic role of Sox2 in melanoma might reflect a distinct stem cell program active in neural crest stem cells and during melanoma formation.
Results suggest that the simultaneous evaluation of SRY (sex determining region Y)-box 2 protein (SOX2) and cyclin dependent kinase inhibitor 1A (p21 (show CDKN1A Proteins)) in advanced endometrial cancer patients provides more accurate information for patient prognosis than either alone.
Results suggest that targeting SRY (sex determining region Y)-box 2 protein (SOX2) in ovarian cancer may be therapeutically beneficial.
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 Proteins) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 Proteins) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 Proteins) and Sox2 proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 Proteins) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Proteins).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
CRISPR/Cas9-assisted gene swap provides strong evidence that SOX2 and SOX3 (show SOX3 Proteins) proteins are functionally equivalent in developing brain and testes.
Sox2 is required to specify prosensory competence, but subsequent down-regulation of Sox2 must occur to allow Atoh1 (show ATOH1 Proteins) expression, most likely through a direct interaction with the Atoh1 (show ATOH1 Proteins) promoter.
These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system.
T, cooperatively with WNT (show WNT2 Proteins) signaling, controls the progenitor state and the switch toward the mesodermal fate. Sox2 acts antagonistically and promotes neural development.
Of the 28 proteins, only arginine methyltransferase 7 (PRMT7 (show PRMT7 Proteins)) changed substantially during mouse embryogenesis and promoted the conversion of mouse fibroblasts into iPSCs. Specifically, PRMT7 (show PRMT7 Proteins) replaced SOX2 in a factor-substitution assay, yielding iPSCs
this study shows that Sox2 is expressed in activated B cells, but almost exclusively in those that have undergone IgH class switch recombination, enforced expression of Sox2 in splenic B cells severely inhibits AID expression and IgH class switch recombination, and that deletion of Sox2 increases the frequency of IgH:c-Myc (show MYC Proteins) translocations
Uncovering a Pitx2 (show PITX2 Proteins)-Sox2-Lef-1 (show LEF1 Proteins) transcriptional mechanism that regulates dental epithelial stem cells homeostasis and dental development.
SOX2 has two independent roles during pituitary morphogenesis.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line
Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY (sex determining region Y)-box 2
, FAD-dependent sulfhydryl oxidase-2
, sulfhydryl oxidase 1
, SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, Sox2 transcription factor
, delta EF2a
, sex-determining region Y-box 2
, transcription factor Sox-2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2