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Browse our SOX2 Proteins (SOX2)

Full name:
SRY (Sex Determining Region Y)-Box 2 Proteins (SOX2)
On are 32 SRY (Sex Determining Region Y)-Box 2 (SOX2) Proteins from 12 different suppliers available. Additionally we are shipping SOX2 Antibodies (449) and SOX2 Kits (33) and many more products for this protein. A total of 529 SOX2 products are currently listed.
anop3, cb236, lcc, mcops3, Qscn6, Qsox, RGD1565646, rSOx, sox-2, SRY-box2, wu:fb83g04, wu:fc14d07, Xsox-2, ysb, zgc:65860, zgc:77389
list all proteins Gene Name GeneID UniProt
Rat SOX2 SOX2 84491 Q6IUU3
SOX2 6657 P48431
SOX2 20674 P48432

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SOX2 Proteins (SOX2) by Origin

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Top referenced SOX2 Proteins

  1. Human SOX2 Protein expressed in Escherichia coli (E. coli) - ABIN666968 : Wei, Yang, Zhang, Andrianakos, Hasegawa, Lyu, Chen, Bai, Liu, Pera, Lu: Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. in Stem cells (Dayton, Ohio) 2010 (PubMed)
    Show all 2 references for ABIN666968

  2. Human SOX2 Protein expressed in HEK-293 Cells - ABIN2732450 : Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. in Cell 2015 (PubMed)

More Proteins for SOX2 Interaction Partners

Human SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Data show that Nanog homebox (NANOG) but not (show NANOG Proteins)sex-determining (show NANOG Proteins) region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) express (show SRY Proteins)ion was overexpressed in the endometrium of wome (show POU5F1 Proteins)n with intrauterine adhesion (IUA).

  2. demonstrates the mitotic bookmarking property of SOX2 and reveals its functional importance in pluripotency maintenance and ES cell differentiation.

  3. These findings reveal a novel regulation mechanism of SOX2 phosphorylation mediated by AURKA (show AURKA Proteins) in mitosis and its function in stem cell pluripotency maintenance in cancer cells.

  4. Pattern of p53 (show TP53 Proteins) and particularly SOX2 protein expression in esophageal adenocarcinoma predicts response to neoadjuvant chemoradiotherapy.

  5. photoinduced excess electron transfer assay can be used for analysing cooperativity of proteins in transcription complex using cooperative binding of Pax6 (show PAX6 Proteins) to Sox2 on the regulatory DNA element (DC5 enhancer) as an example.

  6. Sox2 may be an important regulator in development of chemoresistance of lung cancer cells.

  7. find that SOX2 cooperates with PI3K (show PIK3CA Proteins) signaling, which is activated by smoking, to initiate the squamous injury response in basal cells. This response involves SOX9 (show SOX9 Proteins) repression, and, accordingly, SOX2 and PI3K (show PIK3CA Proteins) signaling levels are high during dysplasia, while SOX9 (show SOX9 Proteins) is not expressed

  8. The data indicate that both OCT4 (show POU5F1 Proteins) and SOX2 play important roles in the development of Barrett Esophagus triggered by bile acid reflux.

  9. Results show that Sox2 and PD-L1 (show CD274 Proteins) expression are significantly higher in hepatocellular carcinoma tissues (HCC (show FAM126A Proteins)) and that Sox2 transactivates PD-L1 (show CD274 Proteins) through its promoter providing a novel insight into the function and the interplay of Sox2 and PD-L1 (show CD274 Proteins) in HCC (show FAM126A Proteins).

  10. Oct4 (show POU5F1 Proteins)/Lys (show LYZ Proteins)-156-modulated Oct4 (show POU5F1 Proteins)/Sox2 interaction coordinately controls the epithelial-mesenchymal transition and mesendoderm specification induced by specific differentiation signals.

Xenopus laevis SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.

  3. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  4. Suggest that SOX2 directly upregulates FGF8 (show FGF8 Proteins) gene expression in the early embryonic development of Xenopus.

  5. Continuous expression of Sox1 (show SOX1 Proteins) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.

  6. direct interaction and interdependence between the Otx2 (show OTX2 Proteins) and Sox2 proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.

  7. Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2

  8. A directional Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 has a role in pluripotency in pig embryos

  2. Overexpression of Sox2 or Oct4 (show POU5F1 Proteins) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.

  3. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level

Cow (Bovine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Proteins).

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Sox2 displayed relatively the same methylation levels between sperm and oocytes

Mouse (Murine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. In mouse model of acute uterine injury, Nanog (show NANOG Proteins) homebox (NANOG (show NANOG Proteins)) expression reached a peak at 6 h, while sex-determining region Y (show SRY Proteins)-box2 (SOX2) and octamer-binding protein 4 (OCT4 (show POU5F1 Proteins)) peaked later at 12 h after lipopolysaccharide (LPS (show TLR4 Proteins)) treatment.

  2. In adult hippocampal neuronal precursor cells, RIT1 (show RIT1 Proteins) controls an Akt (show AKT1 Proteins)-dependent signaling cascade, resulting in the stabilization and transcriptional activation of phosphorylated Sox2. This study supports a role for RIT1 (show RIT1 Proteins) in relaying niche-derived signals to neural/stem progenitor cells to control transcription of genes involved in self-renewal and differentiation

  3. bookmarked SOX2 target genes are not differently regulated than non-bookmarked target genes.

  4. Data show that expression of the Oct-4 (show POU5F1 Proteins), Sox2, Klf4 (show KLF4 Proteins), and c-Myc (show MYC Proteins) (OSKM) reprogramming factors induces Cyclin D1 (show CCND1 Proteins) expression, and the increased Cyclin D1 (show CCND1 Proteins) expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.

  5. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 (show SOX11 Proteins) and Sox21 (show SOX21 Proteins) expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox (show QSOX1 Proteins) gene family during the process of palatogenesis

  6. On the other hand, cleft formation and branching morphogenesis was suppressed by knockdown of Brachyury (show TBX1 Proteins) gene, suggesting that Brachyury (show TBX1 Proteins) plays a central role in regulating cell growth and cleft formation in early-stage embryonic mouse salivary gland development

  7. These data reveal that the degradation of Wnt (show WNT2 Proteins) signaling caused by the knockdown of Sox2 results in a lack of cell migration during tooth development.

  8. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 (show ATOH1 Proteins) expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1 (show ATOH1 Proteins).

  9. Data show that the reprogramming factors OCT4 (show POU5F1 Proteins), SOX2, KLF4 (show KLF4 Proteins), and MYC (show MYC Proteins) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  10. SOX2 is a regulatory factor of Prop1 (show PROP1 Proteins) expression

Zebrafish SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.

  2. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury

  3. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.

  4. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.

  5. Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2/3/19a/19b resulted in severe developmental abnormalities.

  6. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration

  7. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs

  8. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line

  9. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.

SOX2 Protein Profile

Protein Summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Alternative names and synonyms associated with SOX2

  • SRY (sex determining region Y)-box 2 (LOC100231711)
  • quiescin Q6 sulfhydryl oxidase 1 (Qsox1)
  • SRY (sex determining region Y)-box 2 (SOX2)
  • SRY (sex determining region Y)-box 2 (Sox2)
  • SRY (sex determining region Y)-box 2 (sox2)
  • SRY-box containing gene 2 (Sox2)
  • SRY-box containing gene 2 (sox2)
  • anop3 protein
  • cb236 protein
  • lcc protein
  • mcops3 protein
  • Qscn6 protein
  • Qsox protein
  • RGD1565646 protein
  • rSOx protein
  • sox-2 protein
  • SRY-box2 protein
  • wu:fb83g04 protein
  • wu:fc14d07 protein
  • Xsox-2 protein
  • ysb protein
  • zgc:65860 protein
  • zgc:77389 protein

Protein level used designations for SOX2

SRY (sex determining region Y)-box 2 , FAD-dependent sulfhydryl oxidase-2 , rQSOX , sulfhydryl oxidase 1 , SRY-related HMG-box gene 2 , transcription factor SOX-2 , transcription factor SOX2 , SRY-box containing gene 2 , Sox2 transcription factor , cSox2 , delta EF2a , XSox2 , XlSOX-2 , sex-determining region Y-box 2 , transcription factor Sox-2 , SRY-box 2 , SRY-related HMG-box 2 , sex determining region Y-box 2 , soxp

100231711 Taeniopygia guttata
84491 Rattus norvegicus
6657 Homo sapiens
499593 Rattus norvegicus
396105 Gallus gallus
488092 Canis lupus familiaris
398000 Xenopus laevis
407739 Sus scrofa
784383 Bos taurus
101110563 Ovis aries
707039 Macaca mulatta
460869 Pan troglodytes
100379629 Felis catus
100714747 Cavia porcellus
20674 Mus musculus
378723 Danio rerio
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