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Human SOX2 Protein expressed in HEK-293 Cells - ABIN2732450
Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. in Cell 2015
Data show that tunicamycin reduces the expression of self-renewal regulator Sox2 at translation level.
Increasing SOX2 reduces growth inhibition mediated by MEK (show MAP2K1 Proteins) and AKT (show AKT1 Proteins) inhibitors; whereas knockdown of SOX2 further reduces growth when Pancreatic ductal adenocarcinoma cells are treated with these inhibitors. Thus, targeting SOX2, or its mode of action, could improve the treatment of Pancreatic ductal adenocarcinoma.
miR (show MLXIP Proteins)-371-5p expression is strongly upregulated in gastric cancer tissues and negatively correlated with SOX2 expression.
This study discloses novel SOX2 target genes driving neuroendocrine differentiation and spread of PC and proposes SOX2 as a functional biomarker of LN metastasization for prostate cancer.
These results suggest that SOX2 may play an important role in carcinogenesis and progression of invasive carcinoma ex pleomorphic adenoma
A positive feedback loop involving the Wnt/beta-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subset in ALK + anaplastic large cell lymphoma.
highly conserved Sox2/Pax6 (show PAX6 Proteins) bound site near the Sprouty2 (show SPRY2 Proteins) locus was verified to promote cooperative dimerization designating Sprouty2 (show SPRY2 Proteins) as a potential target reliant on Sox2/Pax6 (show PAX6 Proteins) cooperativity in several neural cell types.
High SOX2 expression is associated with brain neoplasms.
we demonstrated that CD59 (show CD59 Proteins) regulation by SOX2 is required for stem cell evasion of complement surveillance. This finding highlights the importance of complement surveillance in eliminating CSCs and may suggest CD59 (show CD59 Proteins) as a potential target for cancer therapy.
SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (show MBD2 Proteins) UTX (show KDM6A Proteins) to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 (show SOX17 Proteins) has been shown to initiate human PGC (show PGC Proteins) specification, with its target PRDM1 (show PRDM1 Proteins) suppressing mesendodermal genes
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 Proteins) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 Proteins) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 Proteins) and Sox2 proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 Proteins) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Proteins).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
Stem cell and mesenchymal markers, including sex-determining region Y-box 2 (Sox2), are upregulated in aortic ECs of fat-fed ApoE (show APOE Proteins)(-/-) mice, which suggests that endothelial-mesenchymal transitions (EndMTs) contribute to atherosclerotic lesion calcification
miR (show MLXIP Proteins)-145 modulation of Sox2-Lin28 (show LIN28A Proteins)/let-7 network is crucial for neurogenesis progression.
widespread destruction of airway and alveolar epithelial cells following severe influenza infection triggers a wound-healing response that initiates in the airways with the proliferation of rare airway-resident SOX2+ Lin- progenitor cells. These cells then give rise to nascent KRT5 (show KRT5 Proteins)+ cells in remodeled airways and populate the damaged alveolar parenchyma.
The data identify Sox2 as a context-dependent tumor suppressor protein (show TP53 Proteins) that is dispensable for normal tissue regeneration, but restrains stomach adenoma formation through modulation of Wnt (show WNT2 Proteins)-responsive and intestinal genes.
Chd7 (show CHD3 Proteins) is a key regulator of oligodendrocyte precursor cell activation, in which it cooperates with Sox2.
CRISPR/Cas9-assisted gene swap provides strong evidence that SOX2 and SOX3 (show SOX3 Proteins) proteins are functionally equivalent in developing brain and testes.
Sox2 is required to specify prosensory competence, but subsequent down-regulation of Sox2 must occur to allow Atoh1 (show ATOH1 Proteins) expression, most likely through a direct interaction with the Atoh1 (show ATOH1 Proteins) promoter.
These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system.
Sox2 plays an essential role in melanocyte transformation and melanoma growth.
The lack of a tumorigenic role of Sox2 in melanoma might reflect a distinct stem cell program active in neural crest stem cells and during melanoma formation.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line
Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY (sex determining region Y)-box 2
, FAD-dependent sulfhydryl oxidase-2
, sulfhydryl oxidase 1
, SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, Sox2 transcription factor
, delta EF2a
, sex-determining region Y-box 2
, transcription factor Sox-2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2