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we demonstrate that PKCepsilon cooperates with the loss of the tumor suppressor Pten for the development of prostate cancer in a mouse model. Mechanistic analysis revealed that PKCe overexpression and Pten loss individually and synergistically upregulate the production of the chemokine (show CCL1 Proteins) CXCL13 (show CXCL13 Proteins), which involves the transcriptional activation of the CXCL13 (show CXCL13 Proteins) gene
These results indicate that PKC (show PRRT2 Proteins) promotes synaptogenesis by activating PSD-95 (show DLG4 Proteins) phosphorylation directly through JNK1 (show MAPK8 Proteins) and calcium/calmodulin-dependent kinase II and also by inducing expression of PSD-95 (show DLG4 Proteins) and synaptophysin (show SYP Proteins).
epsilonPKC phosphorylation and its coevolution with ALDH2 (show ALDH2 Proteins) play an important role in the regulation and protection of ALDH2 (show ALDH2 Proteins) enzyme activity.
PKCepsilon down-regulation suppresses sorting and the cancer stem-like phenotype of renal cell carcinoma (show MOK Proteins) 769P side population cells through the regulation of ABCB1 (show ABCB1 Proteins) transporter and the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins), Stat3 (show STAT3 Proteins) and MAPK/ERK (show MAPK1 Proteins) pathways that are dependent on the phosphorylation effects.
PRKCE plays two major roles in cardiac muscle cells: it takes part in regulating cardiac muscle contraction via targeting the sarcomeric proteins, as well as it modulates cardiac cell energy production and metabolism by targeting cardiac mitochondria. (Review)
PKCepsilon is a key factor for driving the formation of bone metastasis by prostate cancer cells and is a potential therapeutic target for advanced stages of the disease.
Docosahexaenoic acid increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt (show AKT1 Proteins) and PKCepsilon/delta-induced ERK (show EPHB2 Proteins) pathways.
Depletion of PKCepsilon not only enhanced HGF-induced phosphorylation of JNK and paxillin (Ser178) but also prevented c-Met degradation.
miR (show MLXIP Proteins)-34a regulates blood-tumor barrier (BTB) function by targeting PKCepsilon; after phosphorylation, PKCepsilon is activated and contributes to regulation of the expression of tight junction-related proteins, ultimately altering BTB permeability.
PKCepsilon-CREB (show CREB1 Proteins)-Nrf2 (show GABPA Proteins) signalling induces HO-1 (show HMOX1 Proteins) in the vascular endothelium and enhances resistance to inflammation and apoptosis.
inhibition of mu-opioid receptor expression blocks morphine and DAMGO increases in the translocation of NF-kB p65 protein in microglia.a low dose of morphine, exerting its effects via the mu-opioid receptor, increases the DNA-binding activity of NF-kB via PKCepsilon, while a high dose of morphine triggers a nonopiate receptor response mediated by TLR4 and, interestingly, PKC signalling
PKCepsilon signaling in both the nucleus accumbens and central nucleus of the amygdala is a major contributor to binge alcohol drinking and to the genetic propensity to consume excessive amounts of alcohol.
with strain there was significant PKCepsilon translocation to the Z-disc and co-localization with CapZbeta1 or alpha-actinin (show ACTN1 Proteins), which was quantified on confocal images.
Protein kinase C epsilon phosphorylates the alpha4 nAChR (show CHRNA4 Proteins) subunit and regulates recovery from receptor desensitization.
PKCepsilon-CREB (show CREB1 Proteins)-Nrf2 (show NFE2L2 Proteins) signalling induces HO-1 (show HMOX1 Proteins) in the vascular endothelium and enhances resistance to inflammation and apoptosis.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
PKCdelta (show PKCd Proteins) and PKCepsilon have roles in restraining developmental and reactive heart growth
Pathway analysis indicated that monosaccharide metabolism was affected only upon PKCdelta (show PKCd Proteins) deletion, while isoprenoid biosynthesis was affected in a PKCepsilon-specific manner.
Study demonstrates that PKCalpha (show PKCa Proteins), PKCdelta (show PKCd Proteins) and PKCepsilon isoforms are differentially expressed in particular cellular components of pre-pubertal, pubertal and adult mouse ovarian follicles.
data suggest a redundant role between members of the novel Protein Kinase C subfamily that allows for mutual compensation during mouse embryonic development, with vasculogenesis/angiogenesis as an obvious common function of these two Protein Kinase Cs.
These data identify PKCepsilon as a key regulator of cilia slowing in response to combined smoke and alcohol-induced lung injury.
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS (show NOS3 Proteins) post-translational modification
Differential expression of protein kinase C epsilon and an elevation of [Ca(2 (show CA2 Proteins)+)]i are important for acquisition of luteolytic response to PGF2 alpha
By regulating VEGFR2 (show KDR Proteins) expression and activation, PKC-epsilon expression is critical for activation of Akt (show AKT1 Proteins) and eNOS (show NOS3 Proteins) by VEGF (show VEGFA Proteins) and contributes to VEGF (show VEGFA Proteins)-stimulated Erk (show MAPK1 Proteins) activation, whereas PKC-alpha (show PKCa Proteins) has opposite effects.
Activation of PKC induces the translocation of Nrf2 (show NFE2L2 Proteins) and the enhancement of endogenous antioxidant defenses in ischemic preconditioned rabbit heart.
in contrast to protective effects of PKC-epsilon activation in cardiomyocytes, sustained PKC-epsilon activation is detrimental to mitochondrial function and viability in renal proximal tubule cells
Preferential glucose utilization by PKCepsilon hearts is orchestrated by a p-GSK3beta/HIF-1alpha (show HIF1A Proteins)-mediated mechanism.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior.
protein kinase C epsilon type
, protein kinase C, epsilon
, protein kinase C epsilon type-like
, pkc epsilon
, protein kinase C, eta