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Human Polyclonal RAB7 Primary Antibody for FACS, IHC (p) - ABIN652609
Vitelli, Chiariello, Lattero, Bruni, Bucci: Molecular cloning and expression analysis of the human Rab7 GTP-ase complementary deoxyribonucleic acid. in Biochemical and biophysical research communications 1997
Human Polyclonal RAB7 Primary Antibody for IF (p), IHC (p) - ABIN720191
Aboul Naga, Dithmer, Chitadze, Kabelitz, Lucius, Roider, Klettner: Intracellular pathways following uptake of bevacizumab in RPE cells. in Experimental eye research 2015
Prion (show PRNP Antibodies) infection impairs lysosomal degradation capacity by interfering with rab7 (show RAB7A Antibodies) membrane attachment in neuronal cells.
photoreceptor outer segments vesicles engulfed through Lyar-dependent pathway were targeted to phagosomes and colocalized with phagosome marker Rab7 (show RAB7A Antibodies)
B cell Rab7 (show RAB7A Antibodies) mediates induction of activation-induced cytidine deaminase (show AICDA Antibodies) expression and class-switching in T-dependent and T-independent antibody responses.
CREG1 (show CREG1 Antibodies) deficiency influenced the maturation of lysosomes and reduced the espression of Rab7 (show RAB7A Antibodies), which might be involved in CREG1 (show CREG1 Antibodies)-induced cardiomyocyte autophagy.
Tropheryma whipplei blocks the switch from Rab5 (show RAB5A Antibodies) to Rab7 (show RAB7A Antibodies).
ADRB2 (show ADRB2 Antibodies) stimulation has caused a marked increase in the autophagy-targeted lipid droplets (LD) for lysosomal degradation, which is dependent on the LD-associated RAB7 (show RAB7A Antibodies).
Loss of rab7 is better tolerated in naive T cells than the loss of atg5.
Rab7 (show RAB7A Antibodies) is required for LPS (show TLR4 Antibodies)-stimulated lysosome tubulation in macrophages.
Signaling protein ras-related protein rab-7A (show RAB7A Antibodies) and septin 8 (show SEPT8 Antibodies) levels were significantly higher in hippocampus of poor contextual fear conditioning extinguishers.
Rab7a (show RAB7A Antibodies) is an interacting partner of cellular prion protein (show PRNP Antibodies) in neuronal cells.
Data provide new insight into how disease-associated alterations in Rab7 (show RAB7A Antibodies) protein disrupt cellular function in vertebrate sensory neurons. Moreover, findings suggest that defects in axon development may be a previously unrecognized component of Charcot-Marie-Tooth2b disease.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (show Rab5c Antibodies) (early endosomes), Rab11a (show RAB11A Antibodies) (recycling endosomes), and Rab7 (show RAB7A Antibodies) (late endosomes) to study localization and dynamics during development.
show that the maturation of Mtb (show NCAPG2 Antibodies)-containing autophagosomes into autolysosomes required recruitment of the late endosome marker RAB7 (show RAB7B Antibodies), forming the intermediate compartment amphisomes
We validated ANKRD13A as a novel constituent of BCR (show BCR Antibodies) signalosome and showed that BCR (show BCR Antibodies)-induced phosphorylation of RAB7A (show RAB7A Antibodies) at S72 regulates its association with its effector proteins and with endo-lysosomal compartments.
Hepatitis B virus can regulate its own secretion through an activation of the endo-lysosomal and autophagic pathway mediated by Rab7 (show RAB7B Antibodies) activation.
provides molecular insights into the essential role of Vps26 (show VPS26A Antibodies) and Vps35 (show vps35 Antibodies) in Rab7 (show RAB7B Antibodies)-mediated recruitment of the core retromer complex
Data indicate that the secretion of microRNA miR (show MLXIP Antibodies)-143, depends on rab (show HRB Antibodies) GTP-binding (show RND2 Antibodies) proteins Rab7a (show RAB7A Antibodies) and Rab27b (show RAB27B Antibodies).
Bacteria controled the localization or function of host Rab5 (show RAB5A Antibodies) and Rab7 (show RAB7B Antibodies), and therefore modify the maturation from early to late phagosomes.[review]
Regulation of Rab7 (show RAB7B Antibodies) activity by mutant LRRK2 (show LRRK2 Antibodies) in Parkinson's disease impairs membrane trafficking at very late stages of the endocytic pathway.
LKB1 (show STK11 Antibodies) promotes RAB7 (show RAB7B Antibodies)-mediated neuropilin-1 (show NRP1 Antibodies) degradation to inhibit angiogenesis
Taken together, these results suggested that Rab7 (show RAB7B Antibodies) acts as a negative regulator of prostate tumor growth and invasion, providing further evidence for its potential as a tumor suppressor.
This study developed the animal model of CMT2B (show MAD2L1BP Antibodies), modelling one of the mutations (L129F) in Drosophila melanogaster. Behavioural assays show that this model recapitulates several hallmarks of the human disease.
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
RAB7, member RAS oncogene family
, dystrophin-associated glycoprotein 1
, ras-related protein Rab-7a
, Ras-associated protein RAB7
, GTP-binding protein (rab7)
, ras-related protein BRL-RAS
, ras-related protein p23