RAB7A antibody (AA 110-177) (FITC)

Catalog No. ABIN7167379

Product Details anti-RAB7A Antibody (FITC)

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Binding Specificity: AA 110-177

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB7A antibody is conjugated to FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ras-related protein Rab-7a protein (110-177AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAB7A

Target: RAB7A (RAB7A, Member RAS Oncogene Family (RAB7A))

Alternative Name: RAB7A (RAB7A Products)

Synonyms: RAB5 antibody, PRO2706 antibody, RAB7 antibody, Rab7 antibody, rab7 antibody, pro2706 antibody, RAB7A antibody, LOC100231734 antibody, ARABIDOPSIS RAB GTPASE HOMOLOG G2 antibody, ATRAB7A antibody, ATRABG2 antibody, F7D8.20 antibody, F7D8_20 antibody, RAB GTPase homolog 7A antibody, DDBDRAFT_0190210 antibody, DDBDRAFT_0191507 antibody, DDB_0190210 antibody, DDB_0191507 antibody, Rab7a antibody, rab-7 antibody, zgc:64058 antibody, RAB5A, member RAS oncogene family antibody, RAB7A, member RAS oncogene family antibody, RAB7A, member RAS oncogene family L homeolog antibody, rab7A protein antibody, RAB GTPase homolog 7A antibody, Rab GTPase antibody, ras-related protein rab-7a antibody, RAB7, member RAS oncogene family antibody, RAB5A antibody, RAB7A antibody, Rab7a antibody, rab7a.L antibody, rab7a antibody, rab7A antibody, Rab7 antibody, rab7 antibody

Background:

Background: Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Aliases: CMT2B antibody, PRO2706 antibody, PSN antibody, RAB7, member RAS oncogene family antibody, RAB7A antibody, RAB7A, member RAS oncogene family antibody, RAB7A_HUMAN antibody, Ras associated protein RAB7 antibody, Ras related protein Rab7 antibody, Ras related protein Rab7a antibody, Ras-related protein Rab-7a antibody

UniProt: P51149

Pathways: EGFR Signaling Pathway, Maintenance of Protein Location, SARS-CoV-2 Protein Interactome