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The multiple Src (show SRC Proteins) homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 (show BLNK Proteins) molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process.
these data support a role for the novel PP2Ac (show PPP2CA Proteins)-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
CIN85 promotes recycling of TGF-beta (show TGFB1 Proteins) receptors and thereby positively regulates TGF-beta (show TGFB1 Proteins) signaling.
we demonstrate that SEPT9 (show SEPT9 Proteins) negatively regulates EGFR (show EGFR Proteins) degradation by preventing the association of the ubiquitin ligase Cbl (show CBL Proteins) with CIN85, resulting in reduced EGFR (show EGFR Proteins) ubiquitylation
Results support the model that Cbl (show CBL Proteins)-CIN85-endophilin complex is not required for efficient internalization of EGFR (show EGFR Proteins), a prototype RTK.
Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line.
LOX (show LOX Proteins)-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells.
an FRS2beta (show FRS3 Proteins)-CIN85/CD2AP (show Cd2ap Proteins)-Cbl (show CBL Proteins) axis for downregulation of ErbB2 (show ERBB2 Proteins) may regulate ErbB2 (show ERBB2 Proteins) protein levels in physiological and pathological settings
Data show that EGFR (show EGFR Proteins) activation leads to a pronounced src (show SRC Proteins)-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR (show EGFR Proteins) ubiquitination.
this study indicates that high levels of Ruk(l)/CIN85 contribute to the conversion of breast adenocarcinoma cells into a more malignant phenotype via modulation of the Src (show SRC Proteins)/Akt (show AKT1 Proteins) pathway.
CIN85/RukL is involved in endocytosis of nephrin (show NPHS1 Proteins) in podocytes under diabetic conditions, causing podocyte depletion and promoting proteinuria. CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes.
Dab1 (show DAB1 Proteins) mediated the association of CIN85 with ApoER2 (show LRP8 Proteins) or VLDLR (show VLDLR Proteins) in neurons.
Data suggest that Ser587 Cin85 phosphomimetic mutant protein shows dramatically reduced binding to Dab1 (show DAB1 Proteins) (disabled protein 1) (without affecting binding to CapZ (show CAPZA1 Proteins)).
Sh3kbp1 is SUMOylated by SUMO-1 (show SUMO1 Proteins), -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap (show Cd2ap Proteins).
the interaction between SHIP-1 (show INPP5D Proteins) and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 (show BLNK Proteins) and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
a B cell-specific deletion of CIN85 led to impaired T cell-independent type II antibody responses in vivo and diminished IKK-beta (show IKBKB Proteins) activation and cellular responses to B (show TDO2 Proteins) cell receptor cross-linking in vitro
Coexpression of CIN85/Ruk(L) with CD2AP (show Cd2ap Proteins) led to a decreased binding of CIN85/Ruk(L) to nephrin (show NPHS1 Proteins) and podocin, which indicates a functional competition between CD2AP (show Cd2ap Proteins) and CIN85/Ruk(L).
Data indicate an important function of CIN85 (SH3KBP1) in the regulation of dopamine D2 receptor (show DRD2 Proteins) functions and provide a molecular explanation for the hyperactive behaviour of CIN85(Deltaex2) mice.
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
SH3-domain kinase binding protein 1
, SH3 domain-containing kinase-binding protein 1-like
, CD2-binding protein 3
, SH3 domain-containing kinase-binding protein 1
, Src family kinase-binding protein 1
, c-Cbl-interacting protein
, cbl-interacting protein of 85 kDa
, human Src family kinase-binding protein 1
, migration-inducing gene 18
, src-related kinase binding protein-1
, SH3-containing, expressed in tumorigenic astrocytes
, Sh3 containing, expressed in astrocytes
, regulator of ubiquitous kinase
, SH3 domain-containing adapter protein