Browse our CTH Proteins (CTH)

Full name:
Cystathionase (Cystathionine gamma-Lyase) Proteins (CTH)
On are 21 Cystathionase (Cystathionine gamma-Lyase) (CTH) Proteins from 9 different suppliers available. Additionally we are shipping CTH Antibodies (81) and CTH Kits (30) and many more products for this protein. A total of 143 CTH products are currently listed.
0610010I13Rik, AI314617, BC019483, CSE, CTH, Cys3, cysA, DDBDRAFT_0190313, DDBDRAFT_0191318, DDB_0190313, DDB_0191318, H, MGC75946, SCQ11.03c, wu:fb48e03, wu:fb58d08, zgc:66001, zgc:85785
list all proteins Gene Name GeneID UniProt
CTH 1491 P32929
CTH 107869 Q8VCN5
CTH 24962 P18757

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CTH Proteins (CTH) by Origin

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Top referenced CTH Proteins

  1. Human CTH Protein expressed in Wheat germ - ABIN1350649 : Baskar, Li, Moore: Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 (PubMed)
    Show all 3 references for 1350649

  2. Human CTH Protein expressed in Escherichia coli (E. coli) - ABIN667632 : Chiku, Padovani, Zhu, Singh, Vitvitsky, Banerjee: H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for 667632

More Proteins for CTH Interaction Partners

Human Cystathionase (Cystathionine gamma-Lyase) (CTH) interaction partners

  1. ur findings suggest that these two families of amines inhibit cystathionine-gamma-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in Human vascular smooth muscle cells proliferation.

  2. Lipopolysaccharide increases the expression of CSE in human macrophages, increasing H2S synthesis, via ERK (show EPHB2 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway.

  3. Nox4 (show NOX4 Proteins) is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.

  4. The expression of CSE was positively correlated with the severity of gastric ulcer

  5. Our study demonstrates that CSE/H2S system is regulated by miR (show MLXIP Proteins)-216a, and regulates ABCA1 (show ABCA1 Proteins)-mediated cholesterol efflux and cholesterol levels through the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) pathway.

  6. Collectively, our findings indicate that radiation could promote HCC (show FAM126A Proteins) cell invasion through EMT (show ITK Proteins) mediated by endogenous H2S/CSE signaling via the p38MAPK (show MAPK14 Proteins) pathway.

  7. 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide (show SQRDL Proteins) production and function.

  8. An increase of placental mRNA levels in the pre-eclampsia group was observed for methionine synthase (show MTR Proteins) and cystathionine gamma-lyase.

  9. GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.

  10. The miR (show MLXIP Proteins)-30 family are potentially important regulators of cystathionine gamma-lyase gene expression.

Pig (Porcine) Cystathionase (Cystathionine gamma-Lyase) (CTH) interaction partners

  1. Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.

Mouse (Murine) Cystathionase (Cystathionine gamma-Lyase) (CTH) interaction partners

  1. The antiatherosclerotic effect of estrogen is mediated by CSE-generated H2S

  2. Cystathionine-Gamma-Lyase Gene Deletion is associated with reduced inflammation and liver damage.

  3. this study reveals the molecular basis for the differential expression of Cth in mouse models of essential hypertension under basal and pathophysiological conditions.

  4. the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS (show CBS Proteins) or CSE slightly ameliorates the outcome of LPS (show TLR4 Proteins)-induced endotoxemia in vivo.

  5. lung MPO activity increased following induction of sepsis with CLP while siRNA treatment significantly reduced MPO activity. Liver and lung cytokine and chemokine levels in CLP-induced sepsis reduced following treatment with siRNA. These findings show a crucial pro-inflammatory role for H2S synthesized by CSE in macrophages in sepsis and suggest CSE gene silencing with siRNA as a potential therapeutic approach for this co

  6. H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase KO hepatocytes

  7. Endogenous cystathionine gamma-lyase/Hydrogen sulfide (show SQRDL Proteins) regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment

  8. The results of this study suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S.

  9. CSE-H2S increased PPARgamma (show PPARG Proteins) activity by direct sulfhydration at the C139 site, thereby changing glucose into triglyceride storage in adipocytes.

  10. Therefore, our data suggest that DNA hypermethylation of CpG rich region in cse promoter might contribute to the decrease of cse transcription and H2S production in macrophages, and thus contribute to atherosclerosis development.

CTH Protein Profile

Protein Summary

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.

Alternative names and synonyms associated with CTH

  • cystathionase (cystathionine gamma-lyase) (CTH)
  • cystathionine gamma-lyase (SCO3920)
  • cystathionine gamma-lyase (mlr1566)
  • cystathionine gamma-lyase (Ta0080)
  • cystathionine gamma-lyase (MAP3053c)
  • cystathionine gamma-lyase (SPO3344)
  • cystathionine gamma-lyase (CNN01730)
  • cystathionine gamma-lyase (Mmcs_1928)
  • cystathionine gamma-lyase (RHA1_ro06506)
  • cystathionine gamma-lyase (HNE_1212)
  • cystathionine gamma-lyase (MAV_3867)
  • cystathionine gamma-lyase (MSMEG_2394)
  • cystathionine gamma-lyase (Mvan_2142)
  • cystathionine gamma-lyase (SACE_6136)
  • cystathionine gamma-lyase (Mflv_4220)
  • cystathionine gamma-lyase (cysA)
  • cystathionase (cystathionine gamma-lyase) (cth)
  • cystathionase (cystathionine gamma-lyase) (Cth)
  • 0610010I13Rik protein
  • AI314617 protein
  • BC019483 protein
  • CSE protein
  • CTH protein
  • Cys3 protein
  • cysA protein
  • DDBDRAFT_0190313 protein
  • DDBDRAFT_0191318 protein
  • DDB_0190313 protein
  • DDB_0191318 protein
  • H protein
  • MGC75946 protein
  • SCQ11.03c protein
  • wu:fb48e03 protein
  • wu:fb58d08 protein
  • zgc:66001 protein
  • zgc:85785 protein

Protein level used designations for CTH

cystathionine gamma-lyase , cystathionase (cystathionine gamma-lyase) , fb58d08 , cysteine desulfhydrase , cysteine-protein sulfhydrase , gamma-cystathionase , homoserine deaminase , homoserine dehydratase , CTL target antigen , PRB-RA , probasin-related antigen

100171474 Pongo abelii
456939 Pan troglodytes
1099356 Streptomyces coelicolor A3(2)
1225787 Mesorhizobium loti MAFF303099
1455740 Thermoplasma acidophilum DSM 1728
2721428 Mycobacterium avium subsp. paratuberculosis K-10
3195049 Ruegeria pomeroyi DSS-3
3255532 Cryptococcus neoformans var. neoformans JEC21
4110762 Mycobacterium sp. MCS
4224057 Rhodococcus jostii RHA1
4287543 Hyphomonas neptunium ATCC 15444
4525880 Mycobacterium avium 104
4534485 Mycobacterium smegmatis str. MC2 155
4648813 Mycobacterium vanbaalenii PYR-1
4945865 Saccharopolyspora erythraea NRRL 2338
4975533 Mycobacterium gilvum PYR-GCK
8616970 Dictyostelium discoideum AX4
394634 Xenopus (Silurana) tropicalis
494673 Xenopus laevis
100348407 Oryctolagus cuniculus
322055 Danio rerio
1491 Homo sapiens
479991 Canis lupus familiaris
733654 Sus scrofa
107869 Mus musculus
24962 Rattus norvegicus
100720299 Cavia porcellus
539159 Bos taurus
424716 Gallus gallus
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