Browse our CD86 Proteins (CD86)

Full name:
CD86 Molecule Proteins (CD86)
On are 41 CD86 Molecule (CD86) Proteins from 11 different suppliers available. Additionally we are shipping CD86 Antibodies (796) and CD86 Kits (59) and many more products for this protein. A total of 917 CD86 products are currently listed.
B7, B7-2, B7.2, B70, Cd28l2, CD28LG2, CLS1, ETC-1, LAB72, Ly-58, Ly58, MB7, MB7-2, TS/A-2
list all proteins Gene Name GeneID UniProt
CD86 12524 P42082
CD86 942 P42081
CD86 56822  

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CD86 Proteins (CD86) by Origin

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Top referenced CD86 Proteins

  1. Mouse (Murine) CD86 Protein expressed in Human Cells - ABIN2007266 : Azuma, Ito, Yagita, Okumura, Phillips, Lanier, Somoza: B70 antigen is a second ligand for CTLA-4 and CD28. in Nature 1993 (PubMed)
    Show all 5 references for 2007266

  2. Human CD86 Protein expressed in Human Cells - ABIN2003260 : Freeman, Gribben, Boussiotis, Ng, Restivo, Lombard, Gray, Nadler: Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. in Science (New York, N.Y.) 1993 (PubMed)
    Show all 5 references for 2003260

  3. Rat (Rattus) CD86 Protein expressed in Human Cells - ABIN2009059 : Seino, Azuma, Bashuda, Fukao, Yagita, Okumura: CD86 (B70/B7-2) on endothelial cells co-stimulates allogeneic CD4+ T cells. in International immunology 1996 (PubMed)
    Show all 5 references for 2009059

  4. Human CD86 Protein expressed in HEK-293 Cells - ABIN2180621 : Yadav, Sarvetnick: B7-2 regulates survival, phenotype, and function of APCs. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 2 references for 2180621

  5. Cynomolgus CD86 Protein expressed in HEK-293 Cells - ABIN2180853 : Chen, Gault, Shen, Nabavi: Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed)
    Show all 2 references for 2180853

  6. Cynomolgus CD86 Protein expressed in Human Cells - ABIN2010067 : Mark, Donovan, De Sanctis, Krinzman, Kobzik, Linsley, Sayegh, Lederer, Perkins, Finn: Both CD80 and CD86 co-stimulatory molecules regulate allergic pulmonary inflammation. in International immunology 1999 (PubMed)

More Proteins for CD86 Interaction Partners

Mouse (Murine) CD86 Molecule (CD86) interaction partners

  1. B7.2 expressed on skin CD8 (show CD8A Proteins)(+) T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4 (show CTLA4 Proteins), which is highly expressed on skin Tregs.

  2. CTLA-4 (show CTLA4 Proteins)(+) microvesicles can competitively bind B7 costimulatory molecules on bystander dendritic cells, resulting in downregulation of B7 surface expression.

  3. Low CD86 expression is associated with B16 melanoma.

  4. Local administration of CD86 siRNA during the effector phase ameliorates asthma phenotypes.

  5. Meningococcal capsular polysaccharide-loaded vaccine nanoparticles induce expression of CD86.

  6. The genetic inactivation of B7.1/B7.2 deteriorates obesity-related liver steatosis and metabolic dysregulation, likely a result of the intrinsic absence of Tregs in these mice, rendering DKO mice a novel murine model of NASH (show SAMSN1 Proteins).

  7. data show an important role of the adaptive immune system, in particular T cell CD80 (show CD80 Proteins)/86 costimulation molecules, in the physiological regulation of bone resorption and preservation of bone mass

  8. CD80 (show CD80 Proteins) and CD86 costimulatory molecules regulate OT-II CD4 (show CD4 Proteins)(+) T lymphocyte proliferation and cytokine response in cocultures with antigen-presenting cells derived from pregnant and pseudopregnant mice

  9. novel function of CTLA4Ig in tumor immunity and suggest that CD86 on NK cells is an activating receptor and closely involved in the CTLA4Ig-mediated anti-tumor response.

  10. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL (show ICOSLG Proteins) and OX40L (show TNFSF4 Proteins) in B7 deprived mice.

Human CD86 Molecule (CD86) interaction partners

  1. IL-6 (show IL6 Proteins), DEC205 (show LY75 Proteins), and CD86 can be predictive biomarkers for the respiratory and immune effects of ambient PM2.5.

  2. the upregulation of CD86 but not CD80 (show CD80 Proteins) and PD-L1 (show CD274 Proteins) on CD68 (show CD68 Proteins)+ cells in the liver of HBV-infected patients, observed in our study, suggest that the profile of CD68 (show CD68 Proteins)+ cells does not support the induction of proper Th1 (show TH1L Proteins) responses that are needed to clear HBV infection. This might provide an explanation for the absence of potent HBV-specific T cells during chronic HBV infection.

  3. CD86 variants association with susceptibility to multiple sclerosis in Iranian population.

  4. B-cells from patients tolerant to the graft maintained higher IL-10 (show IL10 Proteins) production after CD40 (show CD40 Proteins) ligation, which correlates with lower CD86 expression compared to patients with chronic rejection.

  5. TLR2, TLR4 (show TLR4 Proteins) and CD86 gene polymorphisms are associated with Recurrent aphthous stomatitis.

  6. The SNP CD40 (show CD40 Proteins) -1C>T was associated with the IgG response against PvDBP, whereas IgG antibody titers against PvMSP-119 were influenced by the polymorphism CD86 +1057G>A.

  7. PD-L1 (show CD274 Proteins) expression and the PD-L1 (show CD274 Proteins)/CD86 ratio in CD14 (show NDUFA2 Proteins)(++)CD16 (show CD16 Proteins)(+) monocytes were higher during chronic hepatitis C virus infection.

  8. Data show that induction of CD86 antigen expression on monocytes by human beta Defensin-3 (hBD-3 (show DEFB103A Proteins)) is suppressed by P2X7 purinoceptor (P2X7R (show P2RX7 Proteins)) antagonist.

  9. analysis of the expression of TLR-9 (show TLR9 Proteins), CD86, and CD95 (show FAS Proteins) in circulating B cells of patients with chronic viral hepatitis B or C before and after antiviral therapy

  10. Polymorphisms in CD86 gene have diverse effects on the pathogenesis of pneumonia-induced sepsis.

Pig (Porcine) CD86 Molecule (CD86) interaction partners

  1. Reduced CD86 antigen is associated with melanoma.

  2. The complete cDNA encoding CD86 molecule of miniature swine was cloned, sequenced and analyzed.

Cow (Bovine) CD86 Molecule (CD86) interaction partners

  1. Northern analysis revealed CD80 (show CD80 Proteins) and CD86 mRNAs in luteal tissue, with greatest steady-state concentrations at midcycle

CD86 Protein Profile

Protein Summary

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

Alternative names and synonyms associated with CD86

  • CD86 molecule (CD86)
  • CD86 antigen (Cd86)
  • CD86 molecule (Cd86)
  • CD86/B7-2 costimulatory molecule (LOC554318)
  • B7 protein
  • B7-2 protein
  • B7.2 protein
  • B70 protein
  • Cd28l2 protein
  • CD28LG2 protein
  • CLS1 protein
  • ETC-1 protein
  • LAB72 protein
  • Ly-58 protein
  • Ly58 protein
  • MB7 protein
  • MB7-2 protein
  • TS/A-2 protein

Protein level used designations for CD86 Molecule Proteins (CD86)

CD86 antigen , T-lymphocyte activation antigen CD86 , activation B7-2 antigen , early T cell costimulatory molecule-1 , early T-cell costimulatory molecule 1 , B-lymphocyte activation antigen B7-2 , BU63 , CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) , CTLA-4 counter-receptor B7.2 , FUN-1 , cd86 antigen , membrane glycoprotein , B7-2 protein , co-stimulatory molecule B7-2 , costimulatory molecule , CD86/B7-2 costimulatory molecule , B7-1 costimulatory molecule

470900 Pan troglodytes
493704 Felis catus
714390 Macaca mulatta
12524 Mus musculus
942 Homo sapiens
56822 Rattus norvegicus
403764 Canis lupus familiaris
397441 Sus scrofa
414345 Bos taurus
100008999 Oryctolagus cuniculus
554318 Ovis aries
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