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Human FRS2 Protein expressed in Wheat germ - ABIN1354441
Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. in The Journal of biological chemistry 2007
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They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.
Results identify FRS2 as an oncogene (show RAB1A Proteins) in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications.
Increased expression of FRS2alpha (and FGFR1 (show FGFR1 Proteins)) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma (show MOK Proteins) treated with sorafenib.
The signaling complex appears to integrate the input from FGFR (show FGFR2 Proteins) and EphA4 (show EPHA4 Proteins), and release the output signal through FRS2alpha.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.
The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.
Patient with pigmentation disorders and vitiligo (show MITF Proteins) show decreased expression of mRNA.
Data indicate that the FGFR (show FGFR2 Proteins)/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas.
a novel signaling network containing FRS2, CAP and flotillin-1 (show FLOT1 Proteins)
Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma.
Fgfr (show FGFR2 Proteins) signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.
Analysis of a mutant Fgfr1 (show FGFR1 Proteins) allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 (show SOX2 Proteins) maintenance can be regulated by MAP kinase (show MAPK1 Proteins).
data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK (show EPHB2 Proteins) pathway components in the epididymis.
Genetic evidence further supports that the formation of an Frs2alpha-Shp2 (show PTPN11 Proteins) complex and its recruitment to FGF receptors are crucial for downstream ERK (show EPHB2 Proteins) signaling in this process.
Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
The FGF signaling axis activates mTOR (show FRAP1 Proteins) via the FGF receptor (show FGFR2 Proteins) substrate 2alpha (FRS2alpha)-mediated PI3K/Akt (show AKT1 Proteins) pathway, and suppresses autophagy activity in MEFs.
although Fgfr2 (show FGFR2 Proteins) and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.
Msx2 and Runx2 (show RUNX2 Proteins) likely function together to induce PC-1 (show PCSK1 Proteins) gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK (show MAPK1 Proteins) signaling pathway
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
fibroblast growth factor receptor substrate 2
, FGFR signalling adaptor
, FGFR substrate 2
, FGFR-signaling adaptor SNT
, suc1-associated neurotrophic factor target 1