Browse our FRS2 Proteins (FRS2)

Full name:
Fibroblast Growth Factor Receptor Substrate 2 Proteins (FRS2)
On are 11 Fibroblast Growth Factor Receptor Substrate 2 (FRS2) Proteins from 5 different suppliers available. Additionally we are shipping FRS2 Antibodies (139) and FRS2 Kits (30) and many more products for this protein. A total of 190 FRS2 products are currently listed.
4732458E18, C330018A15Rik, frs2, FRS2A, Frs2alpha, SNT, SNT-1, SNT1, wu:fd21h10, zgc:91973
list all proteins Gene Name GeneID UniProt
FRS2 10818 Q8WU20
FRS2 327826 Q8C180
FRS2 314850  

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FRS2 Proteins (FRS2) by Origin

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Top referenced FRS2 Proteins

  1. Human FRS2 Protein expressed in Wheat germ - ABIN1354441 : Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for 1354441

More Proteins for FRS2 Interaction Partners

Human Fibroblast Growth Factor Receptor Substrate 2 (FRS2) interaction partners

  1. They also demonstrate the potential of overexpressed FRS2alpha as a biomarker for prostate cancer diagnosis, prognosis and response to therapies.

  2. Results identify FRS2 as an oncogene (show RAB1A Proteins) in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications.

  3. Increased expression of FRS2alpha (and FGFR1 (show FGFR1 Proteins)) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma (show MOK Proteins) treated with sorafenib.

  4. The signaling complex appears to integrate the input from FGFR (show FGFR2 Proteins) and EphA4 (show EPHA4 Proteins), and release the output signal through FRS2alpha.

  5. These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development.

  6. The docking protein FRS2alpha is a critical regulator of VEGF receptors signaling.

  7. Patient with pigmentation disorders and vitiligo (show MITF Proteins) show decreased expression of mRNA.

  8. Data indicate that the FGFR (show FGFR2 Proteins)/FRS2 signaling axis was generally activated in about 75% of FRS2-positive high-grade liposarcomas.

  9. a novel signaling network containing FRS2, CAP and flotillin-1 (show FLOT1 Proteins)

  10. Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma.

Mouse (Murine) Fibroblast Growth Factor Receptor Substrate 2 (FRS2) interaction partners

  1. Fgfr (show FGFR2 Proteins) signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha.

  2. Analysis of a mutant Fgfr1 (show FGFR1 Proteins) allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 (show SOX2 Proteins) maintenance can be regulated by MAP kinase (show MAPK1 Proteins).

  3. data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK (show EPHB2 Proteins) pathway components in the epididymis.

  4. Genetic evidence further supports that the formation of an Frs2alpha-Shp2 (show PTPN11 Proteins) complex and its recruitment to FGF receptors are crucial for downstream ERK (show EPHB2 Proteins) signaling in this process.

  5. Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development.

  6. a novel signaling network containing FRS2, CAP and flotillin-1 (show FLOT1 Proteins)

  7. FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.

  8. The FGF signaling axis activates mTOR (show FRAP1 Proteins) via the FGF receptor (show FGFR2 Proteins) substrate 2alpha (FRS2alpha)-mediated PI3K/Akt (show AKT1 Proteins) pathway, and suppresses autophagy activity in MEFs.

  9. although Fgfr2 (show FGFR2 Proteins) and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.

  10. Msx2 and Runx2 (show RUNX2 Proteins) likely function together to induce PC-1 (show PCSK1 Proteins) gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK (show MAPK1 Proteins) signaling pathway

FRS2 Protein Profile

Protein Summary

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Alternative names and synonyms associated with FRS2

  • fibroblast growth factor receptor substrate 2 (FRS2)
  • fibroblast growth factor receptor substrate 2b (frs2b)
  • fibroblast growth factor receptor substrate 2 (Frs2)
  • fibroblast growth factor receptor substrate 2 (LOC100349995)
  • 4732458E18 protein
  • C330018A15Rik protein
  • frs2 protein
  • FRS2A protein
  • Frs2alpha protein
  • SNT protein
  • SNT-1 protein
  • SNT1 protein
  • wu:fd21h10 protein
  • zgc:91973 protein

Protein level used designations for FRS2

fibroblast growth factor receptor substrate 2 , FGFR signalling adaptor , FGFR substrate 2 , FGFR-signaling adaptor SNT , suc1-associated neurotrophic factor target 1 , FRS2-alpha , SNT-1

100052205 Equus caballus
436931 Danio rerio
10818 Homo sapiens
327826 Mus musculus
314850 Rattus norvegicus
100727252 Cavia porcellus
100517823 Sus scrofa
474444 Canis lupus familiaris
538624 Bos taurus
417845 Gallus gallus
101102468 Ovis aries
100349995 Oryctolagus cuniculus
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