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FRS2 Products

(Fibroblast Growth Factor Receptor Substrate 2 (FRS2))

Categories

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

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Featured FRS2 Categories

FRS2 Antibodies

High quality antibodies with extensive validation data.

FRS2 ELISA Kits

Reliable ELISA kits for a wide range of species.

FRS2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FRS2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application IHC (p), WB
Validations
  • (1)
  • (3)
Cat. No. ABIN2855603
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN3184696
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN1858917
Quantity 100 μL
Datasheet Datasheet

Recommended FRS2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966795
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966796
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380814
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended FRS2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (2)
  • (1)
Cat. No. ABIN1354441
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3080265
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3125606
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our FRS2 products

Bitzer, Spahn, Babaei, Horger, Singer, Schulze-Osthoff, Missios, Gatidis, Nann, Mattern, Scheble, Nikolaou, Armeanu-Ebinger, Schulze, Schroeder, Biskup, Beha, Claassen, Ruhm, Poso, Malek: "Targeting extracellular and juxtamembrane FGFR2 mutations in chemotherapy-refractory cholangiocarcinoma." in: NPJ precision oncology, Vol. 5, Issue 1, pp. 80, (2021) (PubMed).

Sun, Zou, Yang, Morita, Gong, Shiba, Akagawa, Yuan: "Inorganic polyphosphates stimulate FGF23 expression through the FGFR pathway." in: Biochemical and biophysical research communications, Vol. 428, Issue 2, pp. 298-302, (2012) (PubMed).

Krejci, Salazar, Goodridge, Kashiwada, Schibler, Jelinkova, Thompson, Wilcox: "STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes." in: Journal of cell science, Vol. 121, Issue Pt 3, pp. 272-81, (2008) (PubMed).

Krejci, Masri, Salazar, Farrington-Rock, Prats, Thompson, Wilcox: "Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins." in: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2929-36, (2007) (PubMed).

Synonyms and alternative names related to FRS2

fibroblast growth factor receptor substrate 2 (FRS2), fibroblast growth factor receptor substrate 2b (frs2b), fibroblast growth factor receptor substrate 2 (Frs2), 4732458E18, C330018A15Rik, frs2, FRS2A, FRS2alpha, Frs2alpha, SNT, SNT-1, SNT1, wu:fd21h10, zgc:91973

Protein level used designations for FRS2

  • fibroblast growth factor receptor substrate 2
  • FGFR signalling adaptor
  • FGFR substrate 2
  • FGFR-signaling adaptor SNT
  • suc1-associated neurotrophic factor target 1
  • FRS2-alpha
  • SNT-1
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