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Insulin Receptor Substrate 1 ELISA Kits (IRS1)
On are 50 Insulin Receptor Substrate 1 (IRS1) ELISA Kits from 12 different suppliers available. Additionally we are shipping Insulin Receptor Substrate 1 Antibodies (586) and Insulin Receptor Substrate 1 Proteins (6) and many more products for this protein. A total of 666 Insulin Receptor Substrate 1 products are currently listed.
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

More ELISA Kits for Insulin Receptor Substrate 1 Interaction Partners

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. miR (show MYLIP ELISA Kits)-146a-5p targets porcine insulin receptor (show INSR ELISA Kits) and could inhibit its protein expression.

  2. TBC1D4, insulin receptor (show INSR ELISA Kits) and GLUT4 (show SLC2A4 ELISA Kits) showed altered expression in some tissues in pre-diabetic pigs.

  3. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.

  2. Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.

  3. G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.

  4. The results suggest that high glucose compromises the insulin (show INS ELISA Kits) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.

  5. The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.

  6. IRS-1 and IRS-2 (show IRS2 ELISA Kits) signaling interaction with the microtubule cytoskeleton and its response to AKT (show AKT1 ELISA Kits) determines the response to microtubule disruption in breast carcinoma cells

  7. Findings suggest that the induction of microRNA miR (show MLXIP ELISA Kits)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS ELISA Kits) resistance by targeting insulin receptor (INSR (show INSR ELISA Kits)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.

  8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (show INS ELISA Kits), IRS2 (show IRS2 ELISA Kits), PPAR-G (show ARF6 ELISA Kits) and CAPN10 (show CAPN10 ELISA Kits) failed to show any association with PCOS in our studied population.

  9. Consistent with these observations, LPIN1 (show LPIN1 ELISA Kits) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (show LPIN1 ELISA Kits) may be a promising drug target for anticancer therapy

  10. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (show IRS2 ELISA Kits) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (show INSR ELISA Kits) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP ELISA Kits)-342

  2. Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.

  3. In conclusion, we have identified that ARL15 acts as an insulin (show INS ELISA Kits)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (show PDPK1 ELISA Kits)/AKT (show AKT1 ELISA Kits) insulin (show INS ELISA Kits) pathway by interacting with its GAP ASAP2 (show ASAP2 ELISA Kits) and activating PDPK1 (show PDPK1 ELISA Kits). This research may provide new insights into GTPase (show RACGAP1 ELISA Kits)-mediated insulin (show INS ELISA Kits) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS ELISA Kits) sensitizati

  4. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (show INS ELISA Kits) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation

  5. Decreased miR (show MLXIP ELISA Kits)-33 levels can up-regulate IRS-2 (show IRS2 ELISA Kits) expression, which appears to compensate for the defects of the insulin (show INS ELISA Kits) signaling pathway in Irs-1 deficient mice.

  6. Acute knockdown of Insr (show INSR ELISA Kits) or both Irs1 and Irs2 (show IRS2 ELISA Kits) in adipocytes increased Adipoq (show ADIPOQ ELISA Kits) mRNA expression but reduced adiponectin (show ADIPOQ ELISA Kits) secretion.

  7. Concentration of SOCS-3 (show SOCS3 ELISA Kits) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 ELISA Kits) protein with both the IR-beta subunit (show POLG ELISA Kits) as well as IRS-1 was found to be decreased by 4-HIL

  8. Authors propose that insulin (show INS ELISA Kits)/IGF-1 (show IGF1 ELISA Kits) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 ELISA Kits) longevity phenotype.

  9. within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 ELISA Kits) signaling regulates Akt (show AKT1 ELISA Kits) largely through IRS (show IARS ELISA Kits)-independent means with little effect upon physiologic insulin (show INS ELISA Kits) sensitivity.

  10. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A ELISA Kits) development and progression.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO ELISA Kits) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 ELISA Kits) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) Antigen Profile

Antigen Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2) Elisa Kit
  • insulin receptor substrate 1 (IRS1) Elisa Kit
  • insulin receptor substrate 1 (Irs1) Elisa Kit
  • insulin receptor substrate 1 (irs1) Elisa Kit
  • G972R Elisa Kit
  • HIRS-1 Elisa Kit
  • irs-1 Elisa Kit
  • IRS1 Elisa Kit
  • irs1-a Elisa Kit
  • IRS1IRM Elisa Kit
  • irsu Elisa Kit

Protein level used designations for IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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