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These effects were exerted by changes on the phosphorylation of IRS-1.
Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.
Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.
G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.
The results suggest that high glucose compromises the insulin (show INS ELISA Kits) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.
The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.
IRS-1 and IRS-2 (show IRS2 ELISA Kits) signaling interaction with the microtubule cytoskeleton and its response to AKT (show AKT1 ELISA Kits) determines the response to microtubule disruption in breast carcinoma cells
Findings suggest that the induction of microRNA miR (show MLXIP ELISA Kits)-1271 by saturated fatty acid palmitate promotes the development of insulin (show INS ELISA Kits) resistance by targeting insulin receptor (INSR (show INSR ELISA Kits)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.
The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (show INS ELISA Kits), IRS2 (show IRS2 ELISA Kits), PPAR-G (show ARF6 ELISA Kits) and CAPN10 (show CAPN10 ELISA Kits) failed to show any association with PCOS in our studied population.
Consistent with these observations, LPIN1 (show LPIN1 ELISA Kits) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (show LPIN1 ELISA Kits) may be a promising drug target for anticancer therapy
EGCG significantly ameliorated insulin (show INS ELISA Kits) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT (show AKT1 ELISA Kits) and ERK (show EPHB2 ELISA Kits)/cAMP response element binding protein (CREB (show CREB ELISA Kits))/brain-derived neurotrophic factor (BDNF (show BDNF ELISA Kits)) signaling pathways.
Pit1 (show POU1F1 ELISA Kits) deletion inhibited USP7 (show USP7 ELISA Kits)/IRS1 dissociation upon insulin (show INS ELISA Kits) stimulation.
TSH improves insulin (show INS ELISA Kits) sensitivity in skeletal muscle by increasing Irs1 gene expression.
Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP ELISA Kits)-342
Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.
In conclusion, we have identified that ARL15 acts as an insulin (show INS ELISA Kits)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (show PDPK1 ELISA Kits)/AKT (show AKT1 ELISA Kits) insulin (show INS ELISA Kits) pathway by interacting with its GAP ASAP2 (show ASAP2 ELISA Kits) and activating PDPK1 (show PDPK1 ELISA Kits). This research may provide new insights into GTPase (show RACGAP1 ELISA Kits)-mediated insulin (show INS ELISA Kits) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS ELISA Kits) sensitizati
These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (show INS ELISA Kits) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation
Decreased miR (show MLXIP ELISA Kits)-33 levels can up-regulate IRS-2 (show IRS2 ELISA Kits) expression, which appears to compensate for the defects of the insulin (show INS ELISA Kits) signaling pathway in Irs-1 deficient mice.
Acute knockdown of Insr or both Irs1 and Irs2 in adipocytes increased Adipoq mRNA expression but reduced adiponectin secretion.
Concentration of SOCS-3 (show SOCS3 ELISA Kits) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 ELISA Kits) protein with both the IR-beta subunit (show POLG ELISA Kits) as well as IRS-1 was found to be decreased by 4-HIL
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO ELISA Kits) genes regulates body weight in rabbits.
miR (show MYLIP ELISA Kits)-146a-5p targets porcine insulin receptor (show INSR ELISA Kits) and could inhibit its protein expression.
TBC1D4, insulin receptor (show INSR ELISA Kits) and GLUT4 (show SLC2A4 ELISA Kits) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 ELISA Kits) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A