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TBC1D4, insulin receptor (show INSR ELISA Kits) and GLUT4 (show SLC2A4 ELISA Kits) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.
High IRS1 expression is associated with hepatocellular carcinoma.
In the renal proximal tubule, insulin (show INS ELISA Kits) signaling via IRS1 is inhibited, while insulin (show INS ELISA Kits) signaling via IRS2 (show IRS2 ELISA Kits) is preserved. Insulin (show INS ELISA Kits) signaling via IRS2 (show IRS2 ELISA Kits) continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.
miR-195 inhibits tumor angiogenesis through suppressing IRS1-VEGF axis.
The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of rheumatoid arthritis, and therefore may be a potential prognostic factor for RA.
In this exploratory analysis, IRS1, ENNP1 and TRIB3 (show TRIB3 ELISA Kits), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS ELISA Kits) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
In accordance with previous studies, our findings suggest that the IRS1 G972R R allele and RR+GR genotype have protective effects for colorectal cancer (CRC (show CALR ELISA Kits)) in overweight/obese patients and for obesity in patients with CRC (show CALR ELISA Kits).
FRET-based translocation assays reveal that insulin (show INS ELISA Kits) promotes the association of both p62 (show GTF2H1 ELISA Kits) and aPKC with the insulin (show INS ELISA Kits)-regulated scaffold IRS-1.
HCV NS5A favors serine phosphorylation of IRS-1, promoting insulin (show INS ELISA Kits) resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.
High IRS1 Expression is associated with Colorectal Cancer.
failed to find any association between the IRS1 Gly972Arg polymorphism and T2DM
Acute knockdown of Insr (show INSR ELISA Kits) or both Irs1 and Irs2 (show IRS2 ELISA Kits) in adipocytes increased Adipoq (show ADIPOQ ELISA Kits) mRNA expression but reduced adiponectin (show ADIPOQ ELISA Kits) secretion.
Concentration of SOCS-3 (show SOCS3 ELISA Kits) protein and coimmunoprecipitation of SOCS-3 (show SOCS3 ELISA Kits) protein with both the IR-beta subunit (show POLG ELISA Kits) as well as IRS-1 was found to be decreased by 4-HIL
Authors propose that insulin (show INS ELISA Kits)/IGF-1 (show IGF1 ELISA Kits) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (show PROP1 ELISA Kits) longevity phenotype.
within the hepatic compartment, mTORC1 --> S6K (show RPS6KB1 ELISA Kits) signaling regulates Akt (show AKT1 ELISA Kits) largely through IRS (show IARS ELISA Kits)-independent means with little effect upon physiologic insulin (show INS ELISA Kits) sensitivity.
Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (show FAM126A ELISA Kits) development and progression.
Insulin receptor substrate-1-mediated insulin (show INS ELISA Kits) signal transduction may be an important factor in the treatment of cognitive decline induced by insulin (show INS ELISA Kits) resistance.
Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation.
melatonin can ameliorate insulin (show INS ELISA Kits) sensitivity by inhibiting Ser307 phosphorylation in IRS-1
Most importantly, treatment of cells with the RhoA (show RHOA ELISA Kits)/ROCK inhibitor, Y-27632, which among its many effects also inhibited serine 636 phosphorylation of IRS-1, had profound effects on cell-substratum adhesion
Results indicate that although IRS (show IARS ELISA Kits) isoforms (irs1 and irs2 (show IRS2 ELISA Kits)) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.
IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (show FTO ELISA Kits) genes regulates body weight in rabbits.
Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (show PAX6 ELISA Kits) and a decreased cell proliferation.
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
, insulin receptor substrate 1
, insulin receptor substrate 1-A