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IRS1 Products

(Insulin Receptor Substrate 1 (IRS1))

Categories

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009].

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Featured IRS1 Categories

IRS1 Antibodies

High quality antibodies with extensive validation data.

IRS1 ELISA Kits

Reliable ELISA kits for a wide range of species.

IRS1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IRS1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (10)
Cat. No. ABIN6255436
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (6)
Cat. No. ABIN6256390
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (8)
Cat. No. ABIN6256264
Quantity 100 μL
Datasheet Datasheet

Recommended IRS1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956767
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967614
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956768
Quantity 96 tests
Datasheet Datasheet

Recommended IRS1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093215
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133871
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7414930
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IRS1 products

Yan, Wang, Jin, Meng, Liu, Liu, Liu, Sun: "Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway." in: Pharmacological research, Vol. 130, pp. 466-480, (2019) (PubMed).

Ratai, Hermainski, Ravichandran, Pongs: "NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice." in: Frontiers in molecular neuroscience, Vol. 12, pp. 78, (2019) (PubMed).

Fernández-de Frutos, Galán-Chilet, Goedeke, Kim, Pardo-Marqués, Pérez-García, Herrero, Fernández-Hernando, Kim, Ramírez et al.: "MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X ..." in: Molecular and cellular biology, Vol. 39, Issue 22, (2019) (PubMed).

Geng, Zhu, Wang, Xie, Li, Wu, Li, Chen, Wang, Meng, Zhang, Chen, Zhong: "P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways." in: Biochemical and biophysical research communications, Vol. 495, Issue 3, pp. 2139-2144, (2018) (PubMed).

Li, Feng, Wei, Liu, Yang, Hou, Zhao, Zhang, Yang: "The Aqueous Extract of Gynura divaricata (L.) DC. Improves Glucose and Lipid Metabolism and Ameliorates Type 2 Diabetes Mellitus." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2018, pp. 8686297, (2018) (PubMed).

Geng, Wang, Zhu, Xie, Li, Wu, Zhu, Jiang, Yang, Li, Chen, Wang, Meng, Zhong: "Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells." in: Biomedicine & pharmacotherapy, Vol. 97, pp. 1538-1543, (2018) (PubMed).

Zhang, Zhang, Tang, Gao, Sun, Yang, Zhou, Hu, Ke, Wu, Ding, Guo, Pei, Chen, Sy, Zhang, Li: "CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling." in: Hepatology (Baltimore, Md.), Vol. 68, Issue 5, pp. 1710-1725, (2018) (PubMed).

Dickson, Hager, Al-Shaibi, Thomas, Baumgard, Ross, Keating: "Impact of heat stress during the follicular phase on porcine ovarian steroidogenic and phosphatidylinositol-3 signaling." in: Journal of animal science, Vol. 96, Issue 6, pp. 2162-2174, (2018) (PubMed).

Zhang, Qin, Zhang, Li, Zhang, Zhao: "Astragalus Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes." in: Molecules (Basel, Switzerland), Vol. 23, Issue 10, (2018) (PubMed).

Rufinatscha, Radlinger, Dobner, Folie, Bon, Profanter, Ress, Salzmann, Staudacher, Tilg, Kaser: "Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes." in: Biochemical and biophysical research communications, Vol. 485, Issue 2, pp. 366-371, (2017) (PubMed).

Synonyms and alternative names related to IRS1

insulin receptor substrate 1 (IRS1), insulin receptor substrate 1 (Irs1), insulin receptor substrate 2 (irs2), insulin receptor substrate 1 S homeolog (irs1.S), G972R, HIRS-1, IRS-1, irs-1, irs1, IRS1, irs1-a, IRS1IRM, irsu

Protein level used designations for IRS1

  • IRS-1
  • pp185
  • insulin receptor substrate 1
  • XIRS-L
  • insulin receptor substrate 1-A
  • xIRS-1-A
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